ironjustice
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 Posted: Fri Nov 28, 2008 4:32 pm Post subject: Trauma Induced Iron Injury Erradication |
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"Iron chelator for recovery after CNS trauma and stroke"
Ceruloplasmin Protects Injured Spinal Cord from Iron-Mediated
Oxidative Damage. Rathore KI, Kerr BJ, Redensek A, López-Vales R,
Jeong SY, Ponka P, David S
J Neurosci 2008 Nov 26; 28(48):12736-12747.
CNS injury-induced hemorrhage and tissue damage leads to excess iron,
which can cause secondary degeneration.
The mechanisms that handle this excess iron are not fully understood.
We report that spinal cord contusion injury (SCI) in mice induces an
"iron homeostatic response" that partially limits iron-catalyzed
oxidative damage.
We show that ceruloplasmin (Cp), a ferroxidase that oxidizes toxic
ferrous iron, is important for this process.
SCI in Cp-deficient mice demonstrates that Cp detoxifies and mobilizes
iron and reduces secondary tissue degeneration and functional loss.
Our results provide new insights into how astrocytes and macrophages
handle iron after SCI.
Importantly, we show that iron chelator treatment has a delayed effect
in improving locomotor recovery between 3 and 6 weeks after SCI.
These data reveal important aspects of the molecular control of CNS
iron homeostasis after SCI and suggest that iron chelator therapy may
improve functional recovery after CNS trauma and hemorrhagic stroke.
The Journal of neuroscience : the official journal of the Society for
Neuroscience [J Neurosci]
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