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 Posted: Fri Oct 31, 2008 2:39 am Post subject: The significance of circadian organization for longevity in |
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http://www.sciencedaily.com/releases/1999/03/990325111049.htm
J Biol Rhythms. 1998 Oct;13(5):430-6.
The significance of circadian organization for longevity in the golden
hamster.
Hurd MW, Ralph MR.
Department of Biology, University of Houston, TX 77204-5513, USA.
While functional roles for biological clocks have been demonstrated in
organisms throughout phylogeny, the adaptive advantages of circadian
organization per se are largely matters of conjecture. It is generally
accepted, though without direct experimental evidence, that organisms
derive primary benefits from the temporal organization of their
physiology and behavior, as well as from the anticipation of daily
changes in their environment and their own fluctuating physiological
requirements. However, the consequences of circadian dysfunction that
might demonstrate a primary adaptive advantage and explain the natural
origins and apparent ubiquity of circadian systems have not been
documented. The authors report that longevity in hamsters is decreased
with a noninvasive disruption of rhythmicity and is increased in older
animals given suprachiasmatic implants that restore higher amplitude
rhythms. The results substantiate the importance of the temporal
organization of physiology and behavior provided by the circadian
clock to the health and longevity of an organism.
PMID: 9783234 [PubMed - indexed for MEDLINE] |
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