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Jason Flint · Guest

fenequedvm@cs.com (Jose Feneque) wrote in message
news:<bdpi67019h6@enews1.newsguy.com>...
[quote]The Future Use Of Nanopharmaceuticals on Veterinary Medicine

Nanoemulsions

Soybean oil in its standard form has very few to no medical applications. But
once it is emulsified with detergents to form nanodrops with measurements less
than 600 nanometers, it can act as a very potent destroyer of pathogens. Its
mode of action is not chemical, but a physical one. When the oil nanodrops
contact the membranes of bacteria or envelope viruses, the drops surface
tension forces a merger with the membrane, blowing it apart and killing the
pathogen. One very important characteristic of the nanoemulsion is that they
don>t affect the cell structures of higher organisms, wich make it ideal to
use
in animals and humans. While the nanoemulsion is enterily safe when applied
externally, unfortanetly scientists have discovered that the oil droplets can
also destroy red blood cells and sperm cell. The reason seems to be that both
types of cells lack the support structures that make other cells invunerable
to
the effects of the nanodrops. This means that the nanoemulsion cannot be used
intravenously. If the research in the nanoemulsion continue showing promising
results, in the near future we may see bactericidal and viricidal products
that
can be used topically in animals and humans.
[/quote]
I object to the rather broad statement that nanoemulsions cannot be
used intravenously, and the blanket statement that nanoemulsions cause
hemolysis. I have a paper coming out on this in the near future.

In fact, I use nanoemulsions to study drug delivery and drug
detoxification in vivo on a daily basis. These animals show no acute
or subacute toxicity and, in fact, continue to thrive as long as 1
month after treatment.

The key here, as will be shown in a forthcoming paper, is that you
should test each constituent component individually and again as part
of the whole nanoemulsion with respect to hemolysis. These tests are
done in human blood, and are extremely easy and inexpensive to
perform. It is true that some nanoemulsions will not be suitable for
IV therapy, but clearly, there are others that are.

If you would like to discuss this further, I am right here in
Gainesville, FL at the University of Florida. Please drop me a line.

Jason Flint
Biological Scientist
Nanomedical Applications in Medicine
University of Florida

Jason Flint · Guest

justintymferbeer@hotmail.com (Savian) wrote in message
news:<bdfr4p0r42@enews1.newsguy.com>...
[quote]This is a rather broad question, but does anyone know of any research
that is being/has been conducting regarding the collapse of
fullerenes/nanotubes? I was thinking about the possibility of
encapsulating something in a buckyball, but in order for it to be
useful, there would have to be a means of removing it. It has been
reported that intense sonication can destroy nanotubes, but I haven>t
read anything confirming this.
[/quote]
We are exploring mechanisms for the "Uncapping" of sealed nanotubes by
using different types of bonds to hold the nanocaps on the end of the
nanotubes. These bonds can be broken upon entering the cell, due to
either enzymatic action, or merely pH changes.

Jason Flint

Jason Flint · Guest

jaflint@ufl.edu (Jason Flint) wrote in message
Oops, that>s
[quote]NanoTECHNOLOGICAL Applications in Medicine
University of Florida[/quote]

Don Steiger · Guest

[quote]

There is a protein folding screensaver which you can download, it works
much like the seti project screensaver where it downloads and folds
proteins, then uploading the results to a master database.

http://www.ep.net.au/ant/main.htm

Check out http://www.stanford.edu/group/pandegroup/folding/[/quote]

Guest

In sci.nanotech, Jason Flint <jaflint@ufl.edu> wrote:

[quote]If you would like to discuss this further, I am right here in
Gainesville, FL at the University of Florida. Please drop me a line.
[/quote]
With all due respect, I>d rather see it discussed right here.

I find it interesting that you have reached conclusions as to toxicity,
but have only stidied the subjects for a month after treatment. Is this a
standard protocol?

What do you feel may be the most promising applications of your research?

--
Words are flowing out like endless rain into a paper cup,
They slither while they pass, they slip away across the universe...
-Lennon/McCartney

Dennis Farr · Guest

http://www.rcsb.org/pdb/

is a repository for those proteins whose crystal structure has been
determined by crystallography and/or NMR.

Jose Feneque · Guest

Thanks to Dr Flint for add some information about the nanoemulsions. Because
the field of nanotechnology is very dynamic, it is impossible to have access to
all the latest information on research at any given time. That the reason this
news group can become one of the best tool to share research information from
around the world.

I would be delight to hear more about your research. Can you please share more
info about the solubilization of Propofol. Although the hospital where I work
don>t use Propofol as part of their anesthetic protocol ( we use thiopental or
valium/ketamine combination for induction and isoflurane for maintenance);
Propofol has been in use in Veterinary Medicine for aprox 7 or more years.

Thanks for your invitation. I am always glad to hear about people working on
nanotechnology applications in the medical field. More glad to know that there
is people in Florida working on it!

Jose Feneque, DVM
Crossroads Animal Hospital
Miami, Florida

Jason Flint · Guest

fenequedvm@cs.com (Jose Feneque) wrote in message
news:<ben4l801vge@enews1.newsguy.com>...
[quote]I would be delight to hear more about your research. Can you please share
more info about the solubilization of Propofol.
Jose Feneque, DVM
Crossroads Animal Hospital
Miami, Florida
[/quote]
Propofol is a widely used intravenous anesthetic. Since propofol is
too hydrophobic, the drug is solubilized in a soybean oil emulsion.
This particle is about 400nM in diameter. Commercially, the most
common Soybean Oil emulsion is "Intralipid". Propofol is commonly
called by its trade name "Diprivan".

The particles I work with are 4 to 25 nM in diameter and have a very
narrow size dispersion. I will post when the article is published.

Jason A. Flint
Nanotechnological Applications in Medicine
University of Florida

erincss · Guest

[quote]Jeremy

This seems like the easiest experiment currently
available to validate diamond mechanochemistry and get some respect
and funding.
[/quote]
I agree Jeremy. And in Unbounding The Future Drexler made an interesting
statement, something to the tune of (not his exact wording) "Once we have a
limited primitive assembler or proto assembler device able to do true mechano
chemistry of organic covalent molecules, funding will start to pour in for
true MNT."

J. Damon Hoff · Guest

[quote]What if a quantum dot is exposed to x-rays? Will it emit similar to UV
excitation?
[/quote]
This is not my field, so take this with a grain of salt; but my best
guess is that x-ray excitation of most quantum dot materials will
generate auger electrons -- not fluorescence.

[quote]If it is ionized, will emit ionized?
[/quote]
Huh? No... any emitted photons will not be ionized...

--Damon

Parallax · Guest

"mg" <nospam@no.com> wrote in message news:<bid10v027o0@enews4.newsguy.com>...
[quote]"J. Damon Hoff" <hoffj@umich.edu> wrote in message
news:bi6ep402rk8@enews3.newsguy.com...

What if a quantum dot is exposed to x-rays? Will it emit similar to UV
excitation?

This is not my field, so take this with a grain of salt; but my best
guess is that x-ray excitation of most quantum dot materials will
generate auger electrons -- not fluorescence.

If it is ionized, will emit ionized?

Huh? No... any emitted photons will not be ionized...

Should have been "will they emit if ionized?". In other words, can the ions
have energy levels and transitions between them, emitting photons, or be
excited after recombination and again - emit photons?
[/quote]
X-ray Fluorescence depends on the quantum dot material and the x-ray
energy. Even very low Z materials emit characteristic x-rays. In some
cases, Auger electrons are the. Even ionized materials can emit
x-rays.

osman arslan · Guest

Hi ;
Grade of chemicals you are looking for are disperse agents. you can find
information and application area of them in www.bayer.com (Especially in the
name of Tween ) Additionally Tego 652 will be usefull for you.

Bye

[quote]From: romagnoli.marcello@unimo.it (Marcello)
Reply-To: sci-nanotech@moderators.isc.org
To: sci.nanotech@nano-tek.org
Subject: [Sci.nanotech] TiO2 nano powder
Date: 9 Sep 2003 16:11:35 GMT

Hi,

I look for reological additives for powders of TiO2. The size is under
1 microns and the liquid phase is water.

Somebody knows one chemical additive that avoid the formation of
agglomerates and increase the grade of dispersion of the particles in
suspension?

Thank in advance for the answer.

Marcello

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[/quote]
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Oliver 'Ojo' Bedford · Guest

ozigun@yahoo.com (ozi) writes:

[quote]Hi All,

I am a newcomer into the nano world. We would like to dynamically
[/quote]
If you seek collaboration it would be helpful to explain who
you are. Background: academic or commercial, country etc.

[quote]Could anybody advise or suggest any nanoparticle system in which we
could observe such changes?
[/quote]
I do not have any expertise in this field, but wouldnt low
temperature cofired ceramics (LTCCs) make up an interesting field
of research? Nanoparticles include silver, aluminium, and also ferrites.

Other suggestions: indium tin oxide (ITO) and antimon tin oxide (ATO),
zinc oxide, which are available as nano powder and produce semi-conducting
coatings after sintering.

Regards,
Oliver

Robert Scheer · Guest

I would like to be a user when you find or create the right software. =
Hope
there>s some response to your inquiry. -Robert Scheer

-----Original Message-----
From: sci.nanotech-bounces@nano-tek.org
[mailto:sci.nanotech-bounces@nano-tek.org] On Behalf Of
Brad.Beveridge@venusia.golgothe.net
Sent: Tuesday, September 16, 2003 10:12 AM
To: sci.nanotech@nano-tek.org
Subject: [Sci.nanotech] CAD systems for Nanotech

Hi guys, firstly I>m new to this list - if I make any fopars please =
stomp on
me so I don>t do it again :) I>ve had a search of the archives in order =
to
look for a CAD program aimed at nanotech and although there has been =
some
discussion, there doesn>t appear to be a defacto standard. I>ve also
searched the web & found a few free (GPL, etc) projects that are in =
various
stages of development - unforuantly none look active.

So I guess my first question is : have I been totally useless in my
searching for CAD systems? (I found NanoCAD and OpenChem, neither look
maintained) What do people use to simulate nano stuff, if anything?

Secondly, how many people are interested in developing an open source
(GPL/LGPL, etc) CAD style sytem aimed at nano-design?

I see the nano CAD system as having two levels

Highlevel:
[quote]From a quick from the top of my head estimate, the following should be
achievable on a modern CPU (>~1Ghz) in realtime[/quote]

- High level design, ie treat casings, etc as rigid-bodies.=20
Corresponds to "parameterized" solids, NOT atomic/molecular level.=20
Should give rough size/shape estimates - allow atomic size devices
(bearings, etc) with very rough approximation calculations.

- Interaction with highlevel design, ie, see wheels/gears etc spin.

- Various modes of visualisation (Look to PyMol as a frontend??)
=20
This should allow low to mid scale complex devices to be created, as =
long as
the results are double checked at a finer detail level.

LowLevel:
This is the harder part, by far. For small simulations at this level (a =
few
dozen atoms) real-time may be feasible - but it should also have an =
offline
mode for crunching numbers without visualisation.

- Simulation of molecular dynamics using a suitable set of equations at
least as good as MM2.

I confess to not knowing much about the lower level simulator, what =
model
would be best, etc. I do know that it is a large task though :)

The higher level task is far easier, I>ve written rigidbody simulators
before & I have the feeling that quite complex moving parts can be =
simulated
at "good enough" accuracy.

So, who is interested? Are there any other programmers that have done =
this
sort of thing & think that there should be a good free nano CAD system =
out
there? Am I way off base in my expectations?

Cheers
Brad

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