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Olafur Pall Olafsson
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 Posted: Sat Oct 04, 2008 1:26 am Post subject: Statins may delay cell senescence and promote DNA repair in |
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This is an important study that may explain some of the benefits of
statins. It lends further support to the use of HMG-CoA reductase
inhibitors for life-extension, as long as CoQ10 is taken along with
them of course to replace any loss of its endogenous synthesis.
Circ Res. 2008 Sep 26;103(7):717-25. Epub 2008 Aug 21.
Related Articles, Links
Click here to read
Statins use a novel Nijmegen breakage syndrome-1-dependent pathway
to accelerate DNA repair in vascular smooth muscle cells.
Mahmoudi M, Gorenne I, Mercer J, Figg N, Littlewood T, Bennett M.
Division of Cardiovascular Medicine, University of Cambridge,
Cambridge, United Kingdom.
Although the hydroxymethylglutaryl-coenzyme A reductase inhibitors
(statins) are widely used in atherosclerosis to reduce serum
cholesterol, statins have multiple other effects, including direct
effects on cells of the vessel wall. Recently, DNA damage, including
telomere shortening, has been identified in vascular smooth muscle
cells (VSMCs) in human atherosclerosis. Although statins reduce DNA
damage in vitro, the mechanisms by which they might protect DNA
integrity in VSMCs are unknown. We show that human atherosclerotic
plaque VSMCs exhibit increased levels of double-stranded DNA breaks
and basal activation of DNA repair pathways involving ataxia
telangiectasia-mutated (ATM) and the histone H2AX in vivo and in
vitro. Oxidant stress induced DNA damage and activated DNA repair
pathways in VSMCs. Statin treatment did not reduce oxidant stress or
DNA damage but markedly accelerated DNA repair. Accelerated DNA repair
required both the Nijmegen breakage syndrome (NBS)-1 protein and the
human double minute protein Hdm2, accompanied by phosphorylation of
Hdm2, dissociation of NBS-1 and Hdm2, inhibition of NBS-1 degradation,
and accelerated phosphorylation of ATM. Statin treatment reduced VSMC
senescence and telomere attrition in culture, accelerated DNA repair
and reduced apoptosis in vivo after irradiation, and reduced ATM/ATR
(ATM and Rad3-related) activity in atherosclerosis. We conclude that
statins activate a novel mechanism of accelerating DNA repair,
dependent on NBS-1 stabilization and Hdm2. Statin treatment may delay
cell senescence and promote DNA repair in atherosclerosis.
Publication Types:
* Research Support, Non-U.S. Gov>t
PMID: 18723444 [PubMed - in process]
Free full text: http://circres.ahajournals.org/cgi/content/full/103/7/717 |
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Paul Antonik Wakfer
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| Posted: Mon Oct 06, 2008 2:59 am Post subject: Re: Statins may delay cell senescence and promote DNA repair |
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Olafur Pall Olafsson wrote:
[quote]This is an important study that may explain some of the benefits of
statins. It lends further support to the use of HMG-CoA reductase
inhibitors for life-extension ---.
[/quote]
The study is certainly an interesting and important result about the
benefits of statins, but I think that it is premature to conclude that
they are life-extending (other than as a fix-up of something that is
entirely preventable) until a similar study is conducted in people who
have adopted a very healthy lifestyle and do not have any
atherosclerosis or arterial plaques (which are causing the effectively
accelerated aging of the underlying vascular smooth muscle cells).
--Paul Wakfer
MoreLife for the rational - http://morelife.org
Reality based tools for more life in quantity and quality
The Self-Sovereign Individual Project - http://selfsip.org
Self-sovereignty, rational pursuit of optimal lifetime happiness,
individual responsibility, social preferencing & social contracting |
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vauxall
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| Posted: Mon Oct 06, 2008 4:12 pm Post subject: Re: Statins may delay cell senescence and promote DNA repair |
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x-no-archive:yes
On Oct 6, 3:59 am, Paul Antonik Wakfer <p...@morelife.org> wrote:
[quote]Olafur Pall Olafsson wrote:
This is an important study that may explain some of the benefits of
statins. It lends further support to the use of HMG-CoA reductase
inhibitors for life-extension ---.
The study is certainly an interesting and important result about the
benefits of statins, but I think that it is premature to conclude that
they are life-extending (other than as a fix-up of something that is
entirely preventable) until a similar study is conducted in people who
have adopted a very healthy lifestyle and do not have any
atherosclerosis or arterial plaques (which are causing the effectively
accelerated aging of the underlying vascular smooth muscle cells).
[/quote]
Besides, reducing homocysteine naturally achieves the same results as
statins without the side effects. Statins may be dangerous:
http://www.patrickholford.com/content.asp?id_Content=1207
"... the apparently unconditional support of the medical profession
for the widespread use of statins conceals a number of concerns about
these drugs that don’t often get much of an airing. Recently the U.S
Food and Drug Administration was forced to disclose, under the Freedom
of Information Act, the number of adverse reactions (over 40,000) and
deaths (over 400) attributed to statins. One American expert claims
about 20% of her patients have some sort of bad reaction. Some very
respectable studies have found that low cholesterol in the elderly can
actually increase their risk of infection. Even more controversially,
there is a debate about whether taking statins actually makes any
difference to how long you live.
The best known side-effect involves muscles problems, such as that
suffered by Carolyn White, a 58-year-old an accountant from San Diego,
diagnosed with high cholesterol who took statins for eight years: "I
couldn>t walk a half a block before my muscles would start to twitch
and cramp and there was painful tingling in my legs and feet."
She has now stopped taking them and can walk properly again but her
doctor Paul Phillips a cardiologist at the Scripps Mercy hospital in
San Diego is concerned that such cases may be the tip of the iceberg.
He has so far diagnosed 200 patients with statin-associated muscle
weakness or pain known as peripheral neuropathy. “What will be the
effect of taking these drugs 30 years down the line?” he wonders.
NASA astronaut Dr. Duane Graveline was prescribed the stain Lipitor
(atorvastatin) after a heart attack. After 6 weeks on the drug he
lost his memory for 6 hours. Later he lost it completely for 12
hours. 100s of examples of statins causing "transient global amnesia"
exist. What would happen if an airline pilot, or surgeon on a statin
had an attack?
A possible reason for these effects is that one of the effects of
statins, besides lowering cholesterol is to also lower an enzyme
called co-enzyme Q10 (Co-Q10) which is found in all cells (especially
those of the heart muscle) and is vital to energy production. This,
say some researchers, could explain the muscle weakness and memory
loss. Some practitioners recommend that anyone taking statins should
also supplement with Co-Q10.
A more serious muscle problem is called rhabdomyolysis, which is not
reversible and can cause liver failure. A statin called Crestor,
launched last year has been linked with at least twenty cases of
severe damage. " |
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John Hasenkam
Guest
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| Posted: Wed Oct 08, 2008 3:57 pm Post subject: Re: Statins may delay cell senescence and promote DNA repair |
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Yes, there are a number of studies indicating statins can impair muscle
healing, in fact some evidence, at a stretch, to implicate these in the
development of chronic heart failure in individuals.
The idea of life extension via statins use is clutching at straws, a good
example of not looking at all the data.
The case below is very similiar to a friend of mine. Stopped taking the
statin and his health has been improving ever since. He was taking a statin
for endothelium benefits, absolutely no atherosclerosis.
John.
"vauxall" <vauxall@virgilio.it> wrote in message
news:4996e702-e7ff-40bc-a81d-709e8684b300@m3g2000hsc.googlegroups.com...
x-no-archive:yes
On Oct 6, 3:59 am, Paul Antonik Wakfer <p...@morelife.org> wrote:
[quote]Olafur Pall Olafsson wrote:
This is an important study that may explain some of the benefits of
statins. It lends further support to the use of HMG-CoA reductase
inhibitors for life-extension ---.
The study is certainly an interesting and important result about the
benefits of statins, but I think that it is premature to conclude that
they are life-extending (other than as a fix-up of something that is
entirely preventable) until a similar study is conducted in people who
have adopted a very healthy lifestyle and do not have any
atherosclerosis or arterial plaques (which are causing the effectively
accelerated aging of the underlying vascular smooth muscle cells).
[/quote]
Besides, reducing homocysteine naturally achieves the same results as
statins without the side effects. Statins may be dangerous:
http://www.patrickholford.com/content.asp?id_Content=1207
"... the apparently unconditional support of the medical profession
for the widespread use of statins conceals a number of concerns about
these drugs that don’t often get much of an airing. Recently the U.S
Food and Drug Administration was forced to disclose, under the Freedom
of Information Act, the number of adverse reactions (over 40,000) and
deaths (over 400) attributed to statins. One American expert claims
about 20% of her patients have some sort of bad reaction. Some very
respectable studies have found that low cholesterol in the elderly can
actually increase their risk of infection. Even more controversially,
there is a debate about whether taking statins actually makes any
difference to how long you live.
The best known side-effect involves muscles problems, such as that
suffered by Carolyn White, a 58-year-old an accountant from San Diego,
diagnosed with high cholesterol who took statins for eight years: "I
couldn>t walk a half a block before my muscles would start to twitch
and cramp and there was painful tingling in my legs and feet."
She has now stopped taking them and can walk properly again but her
doctor Paul Phillips a cardiologist at the Scripps Mercy hospital in
San Diego is concerned that such cases may be the tip of the iceberg.
He has so far diagnosed 200 patients with statin-associated muscle
weakness or pain known as peripheral neuropathy. “What will be the
effect of taking these drugs 30 years down the line?” he wonders.
NASA astronaut Dr. Duane Graveline was prescribed the stain Lipitor
(atorvastatin) after a heart attack. After 6 weeks on the drug he
lost his memory for 6 hours. Later he lost it completely for 12
hours. 100s of examples of statins causing "transient global amnesia"
exist. What would happen if an airline pilot, or surgeon on a statin
had an attack?
A possible reason for these effects is that one of the effects of
statins, besides lowering cholesterol is to also lower an enzyme
called co-enzyme Q10 (Co-Q10) which is found in all cells (especially
those of the heart muscle) and is vital to energy production. This,
say some researchers, could explain the muscle weakness and memory
loss. Some practitioners recommend that anyone taking statins should
also supplement with Co-Q10.
A more serious muscle problem is called rhabdomyolysis, which is not
reversible and can cause liver failure. A statin called Crestor,
launched last year has been linked with at least twenty cases of
severe damage. " |
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