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ironjustice
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 Posted: Thu Nov 06, 2008 1:22 pm Post subject: Smoke Em If You Got Em |
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Sooo .. there isn>t as much loonacy in the theory of nicotine standing
in for nicotinamide as these 'nutritionists' tell you.
People in families predisposed to alzheimers' don>t 'get' alzheimers
if they smoke .. those in the family who DON>T smoke .. DO .. get
alzheimers'.
-------
Vitamin B3 Reduces Alzheimer>s Symptoms, Lesions: Clinical Trial On
Nicotinamide Effect In Alzheimer>s Patients
ScienceDaily (Nov. 5, 2008) — An over-the-counter vitamin in high
doses prevented memory loss in mice with Alzheimer>s disease, and UC
Irvine scientists now are conducting a clinical trial to determine its
effect in humans.
Nicotinamide, a form of vitamin B3, lowered levels of a protein called
phosphorylated tau that leads to the development of tangles, one of
two brain lesions associated with Alzheimer>s disease. The vitamin
also strengthened scaffolding along which information travels in brain
cells, helping to keep neurons alive and further preventing symptoms
in mice genetically wired to develop Alzheimer>s.
"Nicotinamide has a very robust effect on neurons," said Kim Green,
UCI scientist and lead author of the study. "Nicotinamide prevents
loss of cognition in mice with Alzheimer>s disease, and the beauty of
it is we already are moving forward with a clinical trial."
The study appears online Nov. 5 in the Journal of Neuroscience.
Nicotinamide is a water-soluble vitamin sold in health food stores. It
generally is safe but can be toxic in very high doses. Clinical trials
have shown it benefits people with diabetes complications and has anti-
inflammatory properties that may help people with skin conditions.
Nicotinamide belongs to a class of compounds called HDAC inhibitors,
which have been shown to protect the central nervous system in rodent
models of Parkinson>s and Huntington>s diseases and amyotrophic
lateral sclerosis. Clinical trials are underway to learn whether HDAC
inhibitors help ALS and Huntington>s patients.
In the nicotinamide study, Green and his colleague, Frank LaFerla,
added the vitamin to drinking water fed to mice. They tested the
rodents' short-term and long-term memory over time using water-maze
and object-recognition tasks and found that treated Alzheimer>s mice
performed at the same level as normal mice, while untreated
Alzheimer>s mice experienced memory loss.
The nicotinamide, in fact, slightly enhanced cognitive abilities in
normal mice. "This suggests that not only is it good for Alzheimer>s
disease, but if normal people take it, some aspects of their memory
might improve," said LaFerla, UCI neurobiology and behavior professor.
Scientists also found that the nicotinamide-treated animals had
dramatically lower levels of the tau protein that leads to the
Alzheimer>s tangle lesion. The vitamin did not affect levels of the
protein beta amyloid, which clumps in the brain to form plaques, the
second type of Alzheimer>s lesion.
Nicotinamide, they found, led to an increase in proteins that
strengthen microtubules, the scaffolding within brain cells along
which information travels. When this scaffolding breaks down, the
brain cells can die. Neuronal death leads to dementia experienced by
Alzheimer>s patients.
"Microtubules are like highways inside cells. What we>re doing with
nicotinamide is making a wider, more stable highway," Green said. "In
Alzheimer>s disease, this highway breaks down. We are preventing that
from happening."
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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Taka
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| Posted: Thu Nov 06, 2008 3:15 pm Post subject: Re: Smoke Em If You Got Em |
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On Nov 6, 10:22 pm, ironjustice <teamtan...@hotmail.com> wrote:
[quote]Sooo .. there isn>t as much loonacy in the theory of nicotine standing
in for nicotinamide as these 'nutritionists' tell you.
People in families predisposed to alzheimers' don>t 'get' alzheimers
if they smoke .. those in the family who DON>T smoke .. DO .. get
alzheimers'.
[/quote]
Or you can just drink beer ! It>s full of B vitamins including
nicotinamide. The malts & yeast combination in it is a VitB bomb ...
Now why are novadays people so deficient in B vitamins that they have
to smoke and drink beer ??? Are more B vitamins needed in the modern
world full of PUFAs, lack of sleep and stress ? To combat and
detoxify the lipid peroxides ...
Taka |
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ironjustice
Guest
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| Posted: Thu Nov 06, 2008 4:39 pm Post subject: Re: Smoke Em If You Got Em |
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On Nov 6, 7:19 am, clams_casino <PeterGrif...@DrunkinClam.com> wrote:
Smokers pay in all their lives, but for the most part, don>t get back
anywhere near what they contribute.
<<
Now it>s a matter of who is 'better off' .. though .. ?
The incidence of elderly abuse in nursing homes has hit a new level ..
What I>ve seen of old age .. it ain>t all that pretty ..
I>m up to about twelve packs a day ..
Just joking ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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ironjustice
Guest
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| Posted: Thu Nov 06, 2008 4:54 pm Post subject: Re: Smoke Em If You Got Em |
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On Nov 6, 7:15 am, Taka <taka0...@gmail.com> wrote:
Are more B vitamins needed in the modern
world full of PUFAs, lack of sleep and stress ? To combat and
detoxify the lipid peroxides ... <<
BY what .. virtue .. ?
What quality do they have to do that .. ?
Do they say anything about the B vitamins doing that .. AS .. the
'mode of operation' / combat and detoxify the lipid peroxides ?
"Nicotinamide belongs to a class of compounds called HDAC inhibitors"
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
[quote]
Taka[/quote] |
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ironjustice
Guest
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| Posted: Thu Nov 06, 2008 5:14 pm Post subject: Re: Smoke Em If You Got Em |
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On Nov 6, 8:54 am, ironjustice <ironjust...@cashette.com> wrote:
"Nicotinamide belongs to a class of compounds called HDAC inhibitors"
<<
Any significance that the problem with Friedreich ataxia is the
increased iron.
When given this HDAC inhibitor the Friedreich ataxia mouse seems to
be .. cured .. ?
HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia
mouse model.
PLoS ONE (2008) 3: e1958.
M Rai, E SORAGNI, K Jenssen, R Burnett, D Herman, G Coppola, DH
Geschwind, JM Gottesfeld, M Pandolfo
BACKGROUND:
Friedreich ataxia, an autosomal recessive neurodegenerative and
cardiac disease, is caused by abnormally low levels of frataxin, an
essential mitochondrial protein. All Friedreich ataxia patients carry
a GAATTC repeat expansion in the first intron of the frataxin gene,
either in the homozygous state or in compound heterozygosity with
other loss-of-function mutations. The GAA expansion inhibits frataxin
expression through a heterochromatin-mediated repression mechanism.
Histone modifications that are characteristic of silenced genes in
heterochromatic regions occur at expanded alleles in cells from
Friedreich ataxia patients, including increased trimethylation of
histone H3 at lysine 9 and hypoacetylation of histones H3 and H4.
METHODOLOGY/PRINCIPAL FINDINGS:
By chromatin immunoprecipitation, we detected the same heterochromatin
marks in homozygous mice carrying a (GAA)(230) repeat in the first
intron of the mouse frataxin gene (KIKI mice). These animals have
decreased frataxin levels and, by microarray analysis, show
significant gene expression changes in several tissues. We treated
KIKI mice with a novel histone deacetylase inhibitor, compound 106,
which substantially increases frataxin mRNA levels in cells from
Friedreich ataxia individuals. Treatment increased histone H3 and H4
acetylation in chromatin near the GAA repeat and restored wild-type
frataxin levels in the nervous system and heart, as determined by
quantitative RT-PCR and semiquantitative western blot analysis. No
toxicity was observed. Furthermore, most of the differentially
expressed genes in KIKI mice reverted towards wild-type levels.
CONCLUSIONS/SIGNIFICANCE:
Lack of acute toxicity, normalization of frataxin levels and of the
transcription profile changes resulting from frataxin deficiency
provide strong support to a possible efficacy of this or related
compounds in reverting the pathological process in Friedreich ataxia,
a so far incurable neurodegenerative disease.
---------------------
Iron decreases erythropoietin.
Iron overload has been shown IN .. Friedreich>s Ataxia .. one might
wonder if reduction of iron would NOW .. kickstart ..
everything .. ? .. just like in ..
leukemia .. ? .. somewhat like the choke on your .. ride .. ?
"Persistent and significant increase in frataxin levels"
Friedreich>s ataxia: clinical pilot trial with recombinant human
erythropoietin.
Ann Neurol. 2007 Aug 13;
Boesch S, Sturm B, Hering S, Goldenberg H, Poewe W,
Scheiber-Mojdehkar B.
Department of Neurology, Innsbruck Medical University, Innsbruck,
Austria.
To determine the role of recombinant human erythropoietin as a
possible treatment option in Friedreich>s ataxia, we performed an
open-
label clinical pilot study.
Primary outcome measure was the change of frataxin levels at week 8
versus baseline.
Twelve Friedreich>s ataxia patients received 5,000 units recombinant
human erythropoietin three times weekly subcutaneously.
Frataxin levels were measured in isolated lymphocytes by enzyme-linked
immunosorbent assay.
In addition, urinary 8-hydroxydeoxyguanosine and serum peroxides, were
measured.
Treatment with recombinant human erythropoietin showed a persistent
and
significant increase in frataxin levels after 8 weeks (p < 0.01).
All patients showed a reduction of oxidative stress markers. Ann
Neurol
2007.
PMID: 17702040
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
[quote]On Nov 6, 7:15 am, Taka <taka0...@gmail.com> wrote:
Are more B vitamins needed in the modern
world full of PUFAs, lack of sleep and stress ? To combat and
detoxify the lipid peroxides ...
BY what .. virtue .. ?
What quality do they have to do that .. ?
Do they say anything about the B vitamins doing that .. AS .. the
'mode of operation' / combat and detoxify the lipid peroxides ?
"Nicotinamide belongs to a class of compounds called HDAC inhibitors"
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
Taka- Hide quoted text -
- Show quoted text -[/quote] |
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clams_casino
Guest
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| Posted: Thu Nov 06, 2008 9:19 pm Post subject: Re: Smoke Em If You Got Em |
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ironjustice wrote:
[quote]Sooo .. there isn>t as much loonacy in the theory of nicotine standing
in for nicotinamide as these 'nutritionists' tell you.
People in families predisposed to alzheimers' don>t 'get' alzheimers
if they smoke .. those in the family who DON>T smoke .. DO .. get
alzheimers'.
-------
[/quote]
The reason is so obvious - smokers typically don>t live long enough to
develop Alzheimer>s.
Along that line, smoking greatly helps social security funding.
Smokers pay in all their lives, but for the most part, don>t get back
anywhere near what they contribute. |
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Guest
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| Posted: Fri Nov 07, 2008 12:14 am Post subject: Re: Smoke Em If You Got Em |
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"Sooo .. there isn>t as much loonacy in the theory of nicotine standing
in for nicotinamide as these 'nutritionists' tell you.
People in families predisposed to alzheimers' don>t 'get' alzheimers
if they smoke .. those in the family who DON>T smoke .. DO .. get
alzheimers'.
-------
Vitamin B3 Reduces Alzheimer>s Symptoms, Lesions: Clinical Trial On"
What a hoot, all the mistakes amateurs often make in one post. Let us
see if the poster can extradite himself from this one. |
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ironjustice
Guest
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| Posted: Fri Nov 07, 2008 12:31 am Post subject: Re: Smoke Em If You Got Em |
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On Nov 6, 10:14 am, anonym...@nowhere.you.know wrote: snip <<
What part of you ain>t welcome on my threads don>t you understand
there .. aspartame .. boy .. ?
---------
Vitamin B3 Reduces Alzheimer>s Symptoms, Lesions: Clinical Trial On
Nicotinamide Effect In Alzheimer>s Patients
ScienceDaily (Nov. 5, 2008) — An over-the-counter vitamin in high
doses prevented memory loss in mice with Alzheimer>s disease, and UC
Irvine scientists now are conducting a clinical trial to determine
its
effect in humans.
Nicotinamide, a form of vitamin B3, lowered levels of a protein
called
phosphorylated tau that leads to the development of tangles, one of
two brain lesions associated with Alzheimer>s disease. The vitamin
also strengthened scaffolding along which information travels in
brain
cells, helping to keep neurons alive and further preventing symptoms
in mice genetically wired to develop Alzheimer>s.
"Nicotinamide has a very robust effect on neurons," said Kim Green,
UCI scientist and lead author of the study. "Nicotinamide prevents
loss of cognition in mice with Alzheimer>s disease, and the beauty of
it is we already are moving forward with a clinical trial."
The study appears online Nov. 5 in the Journal of Neuroscience.
Nicotinamide is a water-soluble vitamin sold in health food stores.
It
generally is safe but can be toxic in very high doses. Clinical
trials
have shown it benefits people with diabetes complications and has
anti-
inflammatory properties that may help people with skin conditions.
Nicotinamide belongs to a class of compounds called HDAC inhibitors,
which have been shown to protect the central nervous system in rodent
models of Parkinson>s and Huntington>s diseases and amyotrophic
lateral sclerosis. Clinical trials are underway to learn whether HDAC
inhibitors help ALS and Huntington>s patients.
In the nicotinamide study, Green and his colleague, Frank LaFerla,
added the vitamin to drinking water fed to mice. They tested the
rodents' short-term and long-term memory over time using water-maze
and object-recognition tasks and found that treated Alzheimer>s mice
performed at the same level as normal mice, while untreated
Alzheimer>s mice experienced memory loss.
The nicotinamide, in fact, slightly enhanced cognitive abilities in
normal mice. "This suggests that not only is it good for Alzheimer>s
disease, but if normal people take it, some aspects of their memory
might improve," said LaFerla, UCI neurobiology and behavior
professor.
Scientists also found that the nicotinamide-treated animals had
dramatically lower levels of the tau protein that leads to the
Alzheimer>s tangle lesion. The vitamin did not affect levels of the
protein beta amyloid, which clumps in the brain to form plaques, the
second type of Alzheimer>s lesion.
Nicotinamide, they found, led to an increase in proteins that
strengthen microtubules, the scaffolding within brain cells along
which information travels. When this scaffolding breaks down, the
brain cells can die. Neuronal death leads to dementia experienced by
Alzheimer>s patients.
"Microtubules are like highways inside cells. What we>re doing with
nicotinamide is making a wider, more stable highway," Green said. "In
Alzheimer>s disease, this highway breaks down. We are preventing that
from happening."
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
[quote]"Sooo .. there isn>t as much loonacy in the theory of nicotine standing
in for nicotinamide as these 'nutritionists' tell you.
People in families predisposed to alzheimers' don>t 'get' alzheimers
if they smoke .. those in the family who DON>T smoke .. DO .. get
alzheimers'.
-------
Vitamin B3 Reduces Alzheimer>s Symptoms, Lesions: Clinical Trial On"
What a hoot, all the mistakes amateurs often make in one post. Let us
see if the poster can extradite himself from this one.[/quote] |
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John Hasenkam
Guest
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| Posted: Fri Nov 07, 2008 8:08 am Post subject: Re: Smoke Em If You Got Em |
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Ridiculous, smokers have a much greater risk for vascular dementia. The
research re smokers and Alz confers a slight advantage but is easily
outweighed by other health risks.
--
http://healthycuriousity.blogspot.com/
"ironjustice" <teamtanner@hotmail.com> wrote in message
news:fd17d3c3-4f77-4cf6-bc7f-b32f07749d7f@l33g2000pri.googlegroups.com...
Sooo .. there isn>t as much loonacy in the theory of nicotine standing
in for nicotinamide as these 'nutritionists' tell you.
People in families predisposed to alzheimers' don>t 'get' alzheimers
if they smoke .. those in the family who DON>T smoke .. DO .. get
alzheimers'.
-------
Vitamin B3 Reduces Alzheimer>s Symptoms, Lesions: Clinical Trial On
Nicotinamide Effect In Alzheimer>s Patients
ScienceDaily (Nov. 5, 2008) — An over-the-counter vitamin in high
doses prevented memory loss in mice with Alzheimer>s disease, and UC
Irvine scientists now are conducting a clinical trial to determine its
effect in humans.
Nicotinamide, a form of vitamin B3, lowered levels of a protein called
phosphorylated tau that leads to the development of tangles, one of
two brain lesions associated with Alzheimer>s disease. The vitamin
also strengthened scaffolding along which information travels in brain
cells, helping to keep neurons alive and further preventing symptoms
in mice genetically wired to develop Alzheimer>s.
"Nicotinamide has a very robust effect on neurons," said Kim Green,
UCI scientist and lead author of the study. "Nicotinamide prevents
loss of cognition in mice with Alzheimer>s disease, and the beauty of
it is we already are moving forward with a clinical trial."
The study appears online Nov. 5 in the Journal of Neuroscience.
Nicotinamide is a water-soluble vitamin sold in health food stores. It
generally is safe but can be toxic in very high doses. Clinical trials
have shown it benefits people with diabetes complications and has anti-
inflammatory properties that may help people with skin conditions.
Nicotinamide belongs to a class of compounds called HDAC inhibitors,
which have been shown to protect the central nervous system in rodent
models of Parkinson>s and Huntington>s diseases and amyotrophic
lateral sclerosis. Clinical trials are underway to learn whether HDAC
inhibitors help ALS and Huntington>s patients.
In the nicotinamide study, Green and his colleague, Frank LaFerla,
added the vitamin to drinking water fed to mice. They tested the
rodents' short-term and long-term memory over time using water-maze
and object-recognition tasks and found that treated Alzheimer>s mice
performed at the same level as normal mice, while untreated
Alzheimer>s mice experienced memory loss.
The nicotinamide, in fact, slightly enhanced cognitive abilities in
normal mice. "This suggests that not only is it good for Alzheimer>s
disease, but if normal people take it, some aspects of their memory
might improve," said LaFerla, UCI neurobiology and behavior professor.
Scientists also found that the nicotinamide-treated animals had
dramatically lower levels of the tau protein that leads to the
Alzheimer>s tangle lesion. The vitamin did not affect levels of the
protein beta amyloid, which clumps in the brain to form plaques, the
second type of Alzheimer>s lesion.
Nicotinamide, they found, led to an increase in proteins that
strengthen microtubules, the scaffolding within brain cells along
which information travels. When this scaffolding breaks down, the
brain cells can die. Neuronal death leads to dementia experienced by
Alzheimer>s patients.
"Microtubules are like highways inside cells. What we>re doing with
nicotinamide is making a wider, more stable highway," Green said. "In
Alzheimer>s disease, this highway breaks down. We are preventing that
from happening."
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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ironjustice
Guest
|
| Posted: Fri Nov 07, 2008 3:07 pm Post subject: Re: Smoke Em If You Got Em |
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On Nov 6, 10:48 pm, "John Hasenkam" <jo...@goawayplease.com> wrote:
Ridiculous, smokers have a much greater risk for vascular dementia.
The
research re smokers and Alz confers a slight advantage but is easily
outweighed by other health risks. <<
What makes you think this 'Alzheimers' they treated ISN>T vascular
dementia .. ?
Nicotinamide is also called niacin or niacinamide ..
It is used for .. ? .. vascular problems ..
Sooo .. it is coincidence this vitamin is used to treat vascular
problems which cause vascular dementia which **closely** resembles
Alzheimers' .. AND the vitamin is NOW shown to inhibit ..
Alzheimers' ..
Coincidences .. abound ..
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1898481
Niacin in Vascular Disorders and Hyperlipemia
Reviewed by J R A Mitchell
------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
[quote]
--http://healthycuriousity.blogspot.com/"ironjustice" <teamtan...@hotmail..com> wrote in message
news:fd17d3c3-4f77-4cf6-bc7f-b32f07749d7f@l33g2000pri.googlegroups.com...
Sooo .. there isn>t as much loonacy in the theory of nicotine standing
in for nicotinamide as these 'nutritionists' tell you.
People in families predisposed to alzheimers' don>t 'get' alzheimers
if they smoke .. those in the family who DON>T smoke .. DO .. get
alzheimers'.
-------
Vitamin B3 Reduces Alzheimer>s Symptoms, Lesions: Clinical Trial On
Nicotinamide Effect In Alzheimer>s Patients
ScienceDaily (Nov. 5, 2008) — An over-the-counter vitamin in high
doses prevented memory loss in mice with Alzheimer>s disease, and UC
Irvine scientists now are conducting a clinical trial to determine its
effect in humans.
Nicotinamide, a form of vitamin B3, lowered levels of a protein called
phosphorylated tau that leads to the development of tangles, one of
two brain lesions associated with Alzheimer>s disease. The vitamin
also strengthened scaffolding along which information travels in brain
cells, helping to keep neurons alive and further preventing symptoms
in mice genetically wired to develop Alzheimer>s.
"Nicotinamide has a very robust effect on neurons," said Kim Green,
UCI scientist and lead author of the study. "Nicotinamide prevents
loss of cognition in mice with Alzheimer>s disease, and the beauty of
it is we already are moving forward with a clinical trial."
The study appears online Nov. 5 in the Journal of Neuroscience.
Nicotinamide is a water-soluble vitamin sold in health food stores. It
generally is safe but can be toxic in very high doses. Clinical trials
have shown it benefits people with diabetes complications and has anti-
inflammatory properties that may help people with skin conditions.
Nicotinamide belongs to a class of compounds called HDAC inhibitors,
which have been shown to protect the central nervous system in rodent
models of Parkinson>s and Huntington>s diseases and amyotrophic
lateral sclerosis. Clinical trials are underway to learn whether HDAC
inhibitors help ALS and Huntington>s patients.
In the nicotinamide study, Green and his colleague, Frank LaFerla,
added the vitamin to drinking water fed to mice. They tested the
rodents' short-term and long-term memory over time using water-maze
and object-recognition tasks and found that treated Alzheimer>s mice
performed at the same level as normal mice, while untreated
Alzheimer>s mice experienced memory loss.
The nicotinamide, in fact, slightly enhanced cognitive abilities in
normal mice. "This suggests that not only is it good for Alzheimer>s
disease, but if normal people take it, some aspects of their memory
might improve," said LaFerla, UCI neurobiology and behavior professor.
Scientists also found that the nicotinamide-treated animals had
dramatically lower levels of the tau protein that leads to the
Alzheimer>s tangle lesion. The vitamin did not affect levels of the
protein beta amyloid, which clumps in the brain to form plaques, the
second type of Alzheimer>s lesion.
Nicotinamide, they found, led to an increase in proteins that
strengthen microtubules, the scaffolding within brain cells along
which information travels. When this scaffolding breaks down, the
brain cells can die. Neuronal death leads to dementia experienced by
Alzheimer>s patients.
"Microtubules are like highways inside cells. What we>re doing with
nicotinamide is making a wider, more stable highway," Green said. "In
Alzheimer>s disease, this highway breaks down. We are preventing that
from happening."
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk[/quote] |
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ironjustice
Guest
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| Posted: Fri Nov 07, 2008 3:27 pm Post subject: Re: Smoke Em If You Got Em |
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On Nov 7, 7:07 am, ironjustice <ironjust...@cashette.com> wrote:
What makes you think this 'Alzheimers' they treated ISN>T vascular
dementia .. ? <<
"Nicotinamide lowered levels of phosphorylated tau"
"Neither measurement can discriminate entirely"
"It is concluded that neither measurement of phospho-tau, tau nor
A1-42 in CSF can discriminate entirely between dementia and
cognitively non-disturbed controls or between dementia of different
aetiologies"
Cerebrospinal Fluid Phospho-Tau, Total Tau and -Amyloid1-42 in the
Differentiation between Alzheimer>s Disease and Vascular Dementia
Katarina Näggaa, Johan Gottfriesb, Kaj Blennowc,d, Jan Marcussona
aDepartment of Geriatric Medicine, Linköping University Hospital,
Linköping,
bMedicinal Chemistry, AstraZeneca R&D, Mölndal,
cDepartment of Clinical Neuroscience, Section of Experimental
Neuroscience, University of Göteborg, Sahlgrenska University Hospital,
Mölndal, and
dThe Medical Research Council, Sweden
Dement Geriatr Cogn Disord 2002;14:183-190 (DOI: 10.1159/000066023)
Abstract
The two most frequently examined biomarkers in the diagnosis of
dementia are cerebrospinal fluid (CSF) tau and -amyloid1-42 (A1-42).
An assay for tau phosphorylated at threonine 181 (phospho-tau) has
recently been developed.
We studied these three markers in patients with possible Alzheimer>s
disease (AD; n = 23), probable AD (n = 50), AD with relevant
cerebrovascular disease (AD with CVD; n = 14), possible vascular
dementia (VaD; n = 39), probable VaD (n = 36), cognitively impaired (n
= 13) and 27 neurologically healthy controls.
Compared with the controls, tau levels were significantly increased in
possible AD, probable AD, AD with CVD and probable VaD. A1-42 was
decreased in all dementia groups compared with the controls.
In contrast, phospho-tau levels were increased only in probable AD
compared with the controls.
From the results of the present study, it is concluded that neither
measurement of phospho-tau, tau nor A1-42 in CSF can discriminate
entirely between dementia and cognitively non-disturbed controls or
between dementia of different aetiologies in the clinical diagnostic
procedure.
Copyright © 2002 S. Karger AG, Basel
--------------------------------------------------------------------------------
Author Contacts
Katarina Nägga, MD
Department of Geriatric Medicine
Linköping University Hospital
S-581 85 Linköping (Sweden)
Tel. +46 13 224093, Fax +46 13 227389, E-Mail Katarina.Nagga@lio.se
Vol. 14, No. 4, 2002
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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ironjustice
Guest
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| Posted: Fri Nov 07, 2008 9:25 pm Post subject: Re: Smoke Em If You Got Em |
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On Nov 7, 9:45 am, anonym...@nowhere.you.know wrote:snip <<
What part of you ain>t welcome on my threads don>t you understand
there .. aspartame .. boy .. ?
---------
Vitamin B3 Reduces Alzheimer>s Symptoms, Lesions: Clinical Trial On
Nicotinamide Effect In Alzheimer>s Patients
ScienceDaily (Nov. 5, 2008) — An over-the-counter vitamin in high
doses prevented memory loss in mice with Alzheimer>s disease, and UC
Irvine scientists now are conducting a clinical trial to determine
its
effect in humans.
Nicotinamide, a form of vitamin B3, lowered levels of a protein
called
phosphorylated tau that leads to the development of tangles, one of
two brain lesions associated with Alzheimer>s disease. The vitamin
also strengthened scaffolding along which information travels in
brain
cells, helping to keep neurons alive and further preventing symptoms
in mice genetically wired to develop Alzheimer>s.
"Nicotinamide has a very robust effect on neurons," said Kim Green,
UCI scientist and lead author of the study. "Nicotinamide prevents
loss of cognition in mice with Alzheimer>s disease, and the beauty of
it is we already are moving forward with a clinical trial."
The study appears online Nov. 5 in the Journal of Neuroscience.
Nicotinamide is a water-soluble vitamin sold in health food stores.
It
generally is safe but can be toxic in very high doses. Clinical
trials
have shown it benefits people with diabetes complications and has
anti-
inflammatory properties that may help people with skin conditions.
Nicotinamide belongs to a class of compounds called HDAC inhibitors,
which have been shown to protect the central nervous system in rodent
models of Parkinson>s and Huntington>s diseases and amyotrophic
lateral sclerosis. Clinical trials are underway to learn whether HDAC
inhibitors help ALS and Huntington>s patients.
In the nicotinamide study, Green and his colleague, Frank LaFerla,
added the vitamin to drinking water fed to mice. They tested the
rodents' short-term and long-term memory over time using water-maze
and object-recognition tasks and found that treated Alzheimer>s mice
performed at the same level as normal mice, while untreated
Alzheimer>s mice experienced memory loss.
The nicotinamide, in fact, slightly enhanced cognitive abilities in
normal mice. "This suggests that not only is it good for Alzheimer>s
disease, but if normal people take it, some aspects of their memory
might improve," said LaFerla, UCI neurobiology and behavior
professor.
Scientists also found that the nicotinamide-treated animals had
dramatically lower levels of the tau protein that leads to the
Alzheimer>s tangle lesion. The vitamin did not affect levels of the
protein beta amyloid, which clumps in the brain to form plaques, the
second type of Alzheimer>s lesion.
Nicotinamide, they found, led to an increase in proteins that
strengthen microtubules, the scaffolding within brain cells along
which information travels. When this scaffolding breaks down, the
brain cells can die. Neuronal death leads to dementia experienced by
Alzheimer>s patients.
"Microtubules are like highways inside cells. What we>re doing with
nicotinamide is making a wider, more stable highway," Green said. "In
Alzheimer>s disease, this highway breaks down. We are preventing that
from happening."
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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Guest
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| Posted: Fri Nov 07, 2008 11:45 pm Post subject: Re: Smoke Em If You Got Em |
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"What part of you ain>t welcome on my threads don>t you understand
there .. aspartame .. boy .. ?"
Ah shucks, there you went and done it, called me sweet.
You still don>t see how completely in the dark you are in your mistakes
on this one, and many many before it.
What part of you ain>t welcome on my threads don>t you understand
there .. aspartame .. boy .. ?
What an amateur doesn>t know is no barrier to them. |
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Guest
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| Posted: Sat Nov 08, 2008 5:15 am Post subject: Re: Smoke Em If You Got Em |
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| Is tobacco a major source of vit b3? |
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John Hasenkam
Guest
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| Posted: Sat Nov 08, 2008 7:31 am Post subject: Re: Smoke Em If You Got Em |
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What makes you think this 'Alzheimers' they treated ISN>T vascular
dementia .. ?
These are two different conditions. If they were treating "dementias" they
would say so, not "Alzheimers". Please explain why smokers have very high
rates of vascular problems.
--
http://healthycuriousity.blogspot.com/
"ironjustice" <ironjustice@cashette.com> wrote in message
news:d0a951d1-020d-4a82-94ea-74f81d71df74@a17g2000prm.googlegroups.com...
On Nov 6, 10:48 pm, "John Hasenkam" <jo...@goawayplease.com> wrote:
Ridiculous, smokers have a much greater risk for vascular dementia.
The
research re smokers and Alz confers a slight advantage but is easily
outweighed by other health risks. <<
What makes you think this 'Alzheimers' they treated ISN>T vascular
dementia .. ?
Nicotinamide is also called niacin or niacinamide ..
It is used for .. ? .. vascular problems ..
Sooo .. it is coincidence this vitamin is used to treat vascular
problems which cause vascular dementia which **closely** resembles
Alzheimers' .. AND the vitamin is NOW shown to inhibit ..
Alzheimers' ..
Coincidences .. abound ..
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1898481
Niacin in Vascular Disorders and Hyperlipemia
Reviewed by J R A Mitchell
------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
[quote]
--http://healthycuriousity.blogspot.com/"ironjustice"
teamtan...@hotmail.com> wrote in message
news:fd17d3c3-4f77-4cf6-bc7f-b32f07749d7f@l33g2000pri.googlegroups.com...
Sooo .. there isn>t as much loonacy in the theory of nicotine standing
in for nicotinamide as these 'nutritionists' tell you.
People in families predisposed to alzheimers' don>t 'get' alzheimers
if they smoke .. those in the family who DON>T smoke .. DO .. get
alzheimers'.
-------
Vitamin B3 Reduces Alzheimer>s Symptoms, Lesions: Clinical Trial On
Nicotinamide Effect In Alzheimer>s Patients
ScienceDaily (Nov. 5, 2008) — An over-the-counter vitamin in high
doses prevented memory loss in mice with Alzheimer>s disease, and UC
Irvine scientists now are conducting a clinical trial to determine its
effect in humans.
Nicotinamide, a form of vitamin B3, lowered levels of a protein called
phosphorylated tau that leads to the development of tangles, one of
two brain lesions associated with Alzheimer>s disease. The vitamin
also strengthened scaffolding along which information travels in brain
cells, helping to keep neurons alive and further preventing symptoms
in mice genetically wired to develop Alzheimer>s.
"Nicotinamide has a very robust effect on neurons," said Kim Green,
UCI scientist and lead author of the study. "Nicotinamide prevents
loss of cognition in mice with Alzheimer>s disease, and the beauty of
it is we already are moving forward with a clinical trial."
The study appears online Nov. 5 in the Journal of Neuroscience.
Nicotinamide is a water-soluble vitamin sold in health food stores. It
generally is safe but can be toxic in very high doses. Clinical trials
have shown it benefits people with diabetes complications and has anti-
inflammatory properties that may help people with skin conditions.
Nicotinamide belongs to a class of compounds called HDAC inhibitors,
which have been shown to protect the central nervous system in rodent
models of Parkinson>s and Huntington>s diseases and amyotrophic
lateral sclerosis. Clinical trials are underway to learn whether HDAC
inhibitors help ALS and Huntington>s patients.
In the nicotinamide study, Green and his colleague, Frank LaFerla,
added the vitamin to drinking water fed to mice. They tested the
rodents' short-term and long-term memory over time using water-maze
and object-recognition tasks and found that treated Alzheimer>s mice
performed at the same level as normal mice, while untreated
Alzheimer>s mice experienced memory loss.
The nicotinamide, in fact, slightly enhanced cognitive abilities in
normal mice. "This suggests that not only is it good for Alzheimer>s
disease, but if normal people take it, some aspects of their memory
might improve," said LaFerla, UCI neurobiology and behavior professor.
Scientists also found that the nicotinamide-treated animals had
dramatically lower levels of the tau protein that leads to the
Alzheimer>s tangle lesion. The vitamin did not affect levels of the
protein beta amyloid, which clumps in the brain to form plaques, the
second type of Alzheimer>s lesion.
Nicotinamide, they found, led to an increase in proteins that
strengthen microtubules, the scaffolding within brain cells along
which information travels. When this scaffolding breaks down, the
brain cells can die. Neuronal death leads to dementia experienced by
Alzheimer>s patients.
"Microtubules are like highways inside cells. What we>re doing with
nicotinamide is making a wider, more stable highway," Green said. "In
Alzheimer>s disease, this highway breaks down. We are preventing that
from happening."
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk[/quote] |
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