| View previous topic :: View next topic |
| Author |
Message |
Guest
|
 Posted: Mon Nov 10, 2008 8:07 am Post subject: Re: Smoke Em If You Got Em |
 |
|
"Stay off my threads ..
You have for a number of years morphed into different disguises to
hawk your aspartame wares .. haven>t ya ...
Been called a whack by EVERYONE it seems .. obviously with good ..
reason .."
Oh dear, the paranoia is more advanced then we first suspected. Prove I
am the person you think resides under your bed.
Confusion is one primary symptom of low iron, along with other cognitive
and mental disorders.
Just because you are paranoid does not mean someone will not come along
after to clean up your messes so others will not be hurt. |
|
| |
|
 Back to top |
ironjustice
Guest
|
| Posted: Mon Nov 10, 2008 4:19 pm Post subject: Re: Smoke Em If You Got Em |
|
|
On Nov 10, 7:50 am, anonym...@nowhere.you.know wrote:snip <<
You>ve been told a number of times to stay off my threads ..
aspartame
boy ..
Stay off my threads ..
Been called a whack by EVERYONE it seems .. obviously with good ..
reason ..
Take all those .. whacko .. conclusions your theories AND personality
AND weird .. fkg .. hat .. somewhere OTHER than **my** threads ..
whacko ..
Go update your blogs ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
|
| |
|
| Back to top |
ironjustice
Guest
|
| Posted: Mon Nov 10, 2008 5:42 pm Post subject: Re: Smoke Em If You Got Em |
|
|
On Nov 10, 9:05 am, anonym...@nowhere.you.know wrote:snip <<
Been called a whack by EVERYONE it seems .. obviously with good ..
reason ..
Take all those .. whacko .. conclusions your theories AND personality
AND weird .. fkg .. hat .. somewhere OTHER than **my** threads ..
whacko ..
Go update your blogs ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
|
| |
|
| Back to top |
ironjustice
Guest
|
| Posted: Mon Nov 10, 2008 6:19 pm Post subject: Re: Smoke Em If You Got Em |
|
|
On Nov 8, 9:08 am, ironjustice <ironjust...@cashette.com> wrote:the
other argument being they are **metal** chelators <<
"Metal chelating properties of nicotine"
Both the d-(+) and l-(-) Enantiomers of Nicotine Inhibit Abeta
Aggregation and
Cytotoxicity.
Moore SA, Huckerby TN, Gibson GL, Fullwood NJ, Turnbull S, Tabner BJ,
El-Agnaf
OM, Allsop D.
Department of Biological Sciences and Magnetic Resonance Laboratory,
University
of Lancaster, Lancaster LA1 4YQ, U.K.
The underlying cause of Alzheimer>s disease is thought to be the
aggregation of
monomeric beta-amyloid (Abeta), through a series of toxic oligomers,
which
forms the mature amyloid fibrils that accumulate at the center of
senile
plaques.
It has been reported that l-(-)-nicotine prevents Abeta aggregation
and toxicity, and inhibits senile plaque formation.
Previous NMR studies have suggested that this could be due to
the specific binding of l-(-)-nicotine to histidine residues (His(6),
His(13),
and His(14)) in the peptide.
Here, we have looked at the effects of both of the l-(-) and d-(+)
optical
enantiomers of nicotine on the aggregation and cytotoxicity of
Abeta(1-40). Surprisingly, both enantiomers inhibited aggregation of
the peptide and
reduced the toxic effectsof the peptide on cells.
In NMR studies with Abeta(1-40), both enantiomers of nicotine were
seen to interact with the three histidine residues.
Overall, our data indicate that nicotine can delay Abeta fibril
formation and maintain a population of less toxic Abeta species.
This effect cannot be due to a highly specific binding interaction
between nicotine and Abeta, as previously thought, but could be due
instead to weaker, relatively nonspecific binding, or to the
antioxidant or metal chelating properties of nicotine. d-(+)-Nicotine,
being biologically much less active than l-(-)-nicotine, might be a
useful
therapeutic agent.
PMID: 14730987
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
|
| |
|
| Back to top |
ironjustice
Guest
|
| Posted: Mon Nov 10, 2008 6:45 pm Post subject: Re: Smoke Em If You Got Em |
|
|
On Nov 10, 10:19 am, ironjustice <ironjust...@cashette.com> wrote:the
other argument being they are **metal** chelators "Metal chelating
properties of nicotine" <<
Iron: a new target for pharmacological intervention in
neurodegenerative diseases.
Semin Pediatr Neurol. 2006 Sep;13(3):186-97.
Whitnall M, Richardson DR.
Iron Metabolism and Chelation Program, Department of Pathology,
University of Sydney, Sydney, New South Wales, Australia.
Iron (Fe) is an essential element that is imperative for the redox-
driven processes of oxygen transport, electron transport, and DNA
synthesis.
However, in the absence of appropriate storage or chelation, excess-
free Fe readily participates in the formation of toxic-free radicals,
inducing oxidative stress and apoptosis.
A growing body of evidence suggests that Fe may play some role in
neurodegenerative diseases such as Huntington disease, Alzheimer>s
disease, Parkinson>s disease, and particularly Friedreich>s ataxia.
This review examines the role of Fe in the pathology of these
conditions and the potential use of Fe chelators as therapeutic agents
for the treatment of neurodegenerative disorders.
Consideration is given to the features that comprise a clinically
successful Fe chelator, with focus on the development of ligands such
as desferrioxamine, clioquinol, pyridoxal isonicotinoyl hydrazone, and
other novel aroylhydrazones.
PMID: 17101458
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
[quote]
Both the d-(+) and l-(-) Enantiomers of Nicotine Inhibit Abeta
Aggregation and
Cytotoxicity.
Moore SA, Huckerby TN, Gibson GL, Fullwood NJ, Turnbull S, Tabner BJ,
El-Agnaf
OM, Allsop D.
Department of Biological Sciences and Magnetic Resonance Laboratory,
University
of Lancaster, Lancaster LA1 4YQ, U.K.
The underlying cause of Alzheimer>s disease is thought to be the
aggregation of
monomeric beta-amyloid (Abeta), through a series of toxic oligomers,
which
forms the mature amyloid fibrils that accumulate at the center of
senile
plaques.
It has been reported that l-(-)-nicotine prevents Abeta aggregation
and toxicity, and inhibits senile plaque formation.
Previous NMR studies have suggested that this could be due to
the specific binding of l-(-)-nicotine to histidine residues (His(6),
His(13),
and His(14)) in the peptide.
Here, we have looked at the effects of both of the l-(-) and d-(+)
optical
enantiomers of nicotine on the aggregation and cytotoxicity of
Abeta(1-40). Surprisingly, both enantiomers inhibited aggregation of
the peptide and
reduced the toxic effectsof the peptide on cells.
In NMR studies with Abeta(1-40), both enantiomers of nicotine were
seen to interact with the three histidine residues.
Overall, our data indicate that nicotine can delay Abeta fibril
formation and maintain a population of less toxic Abeta species.
This effect cannot be due to a highly specific binding interaction
between nicotine and Abeta, as previously thought, but could be due
instead to weaker, relatively nonspecific binding, or to the
antioxidant or metal chelating properties of nicotine. d-(+)-Nicotine,
being biologically much less active than l-(-)-nicotine, might be a
useful
therapeutic agent.
PMID: 14730987
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk[/quote] |
|
| |
|
| Back to top |
ironjustice
Guest
|
| Posted: Mon Nov 10, 2008 8:22 pm Post subject: Re: Smoke Em If You Got Em |
|
|
On Nov 10, 11:52 am, anonym...@nowhere.you.know wrote:snip <<
Been called a whack by EVERYONE it seems .. obviously with good ..
reason ..
Take all those .. whacko .. conclusions your theories AND personality
AND weird .. fkg .. hat .. somewhere OTHER than **my** threads ..
whacko ..
Go update your blogs ..
Iron: a new target for pharmacological intervention in
neurodegenerative diseases.
Semin Pediatr Neurol. 2006 Sep;13(3):186-97.
Whitnall M, Richardson DR.
Iron Metabolism and Chelation Program, Department of Pathology,
University of Sydney, Sydney, New South Wales, Australia.
Iron (Fe) is an essential element that is imperative for the redox-
driven processes of oxygen transport, electron transport, and DNA
synthesis.
However, in the absence of appropriate storage or chelation, excess-
free Fe readily participates in the formation of toxic-free radicals,
inducing oxidative stress and apoptosis.
A growing body of evidence suggests that Fe may play some role in
neurodegenerative diseases such as Huntington disease, Alzheimer>s
disease, Parkinson>s disease, and particularly Friedreich>s ataxia.
This review examines the role of Fe in the pathology of these
conditions and the potential use of Fe chelators as therapeutic
agents
for the treatment of neurodegenerative disorders.
Consideration is given to the features that comprise a clinically
successful Fe chelator, with focus on the development of ligands such
as desferrioxamine, clioquinol, pyridoxal isonicotinoyl hydrazone,
and
other novel aroylhydrazones.
PMID: 17101458
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
|
| |
|
| Back to top |
ironjustice
Guest
|
| Posted: Mon Nov 10, 2008 8:22 pm Post subject: Re: Smoke Em If You Got Em |
|
|
On Nov 10, 11:55 am, anonym...@nowhere.you.know wrote:snip <<
Been called a whack by EVERYONE it seems .. obviously with good ..
reason ..
Take all those .. whacko .. conclusions your theories AND personality
AND weird .. fkg .. hat .. somewhere OTHER than **my** threads ..
whacko ..
Go update your blogs ..
Iron: a new target for pharmacological intervention in
neurodegenerative diseases.
Semin Pediatr Neurol. 2006 Sep;13(3):186-97.
Whitnall M, Richardson DR.
Iron Metabolism and Chelation Program, Department of Pathology,
University of Sydney, Sydney, New South Wales, Australia.
Iron (Fe) is an essential element that is imperative for the redox-
driven processes of oxygen transport, electron transport, and DNA
synthesis.
However, in the absence of appropriate storage or chelation, excess-
free Fe readily participates in the formation of toxic-free radicals,
inducing oxidative stress and apoptosis.
A growing body of evidence suggests that Fe may play some role in
neurodegenerative diseases such as Huntington disease, Alzheimer>s
disease, Parkinson>s disease, and particularly Friedreich>s ataxia.
This review examines the role of Fe in the pathology of these
conditions and the potential use of Fe chelators as therapeutic
agents
for the treatment of neurodegenerative disorders.
Consideration is given to the features that comprise a clinically
successful Fe chelator, with focus on the development of ligands such
as desferrioxamine, clioquinol, pyridoxal isonicotinoyl hydrazone,
and
other novel aroylhydrazones.
PMID: 17101458
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
|
| |
|
| Back to top |
ironjustice
Guest
|
| Posted: Mon Nov 10, 2008 8:22 pm Post subject: Re: Smoke Em If You Got Em |
|
|
On Nov 10, 11:56 am, anonym...@nowhere.you.know wrote:snip <<
Been called a whack by EVERYONE it seems .. obviously with good ..
reason ..
Take all those .. whacko .. conclusions your theories AND personality
AND weird .. fkg .. hat .. somewhere OTHER than **my** threads ..
whacko ..
Go update your blogs ..
Iron: a new target for pharmacological intervention in
neurodegenerative diseases.
Semin Pediatr Neurol. 2006 Sep;13(3):186-97.
Whitnall M, Richardson DR.
Iron Metabolism and Chelation Program, Department of Pathology,
University of Sydney, Sydney, New South Wales, Australia.
Iron (Fe) is an essential element that is imperative for the redox-
driven processes of oxygen transport, electron transport, and DNA
synthesis.
However, in the absence of appropriate storage or chelation, excess-
free Fe readily participates in the formation of toxic-free radicals,
inducing oxidative stress and apoptosis.
A growing body of evidence suggests that Fe may play some role in
neurodegenerative diseases such as Huntington disease, Alzheimer>s
disease, Parkinson>s disease, and particularly Friedreich>s ataxia.
This review examines the role of Fe in the pathology of these
conditions and the potential use of Fe chelators as therapeutic
agents
for the treatment of neurodegenerative disorders.
Consideration is given to the features that comprise a clinically
successful Fe chelator, with focus on the development of ligands such
as desferrioxamine, clioquinol, pyridoxal isonicotinoyl hydrazone,
and
other novel aroylhydrazones.
PMID: 17101458
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
|
| |
|
| Back to top |
Guest
|
| Posted: Mon Nov 10, 2008 9:50 pm Post subject: Re: Smoke Em If You Got Em |
|
|
Just because you are paranoid does not mean someone will not come along
after to clean up your messes so others will not be hurt.
Hmmmm, wonder if tobacco helps with low iron, ya know, all that vit b3
in it and all. |
|
| |
|
| Back to top |
Guest
|
| Posted: Mon Nov 10, 2008 11:05 pm Post subject: Re: Smoke Em If You Got Em |
|
|
Tell us again how a toxic substance found in tobacco is the same as vit
b3. Do you by any chance partake of that toxic substance?
Here comes de broom. |
|
| |
|
| Back to top |
Guest
|
| Posted: Tue Nov 11, 2008 1:52 am Post subject: Re: Smoke Em If You Got Em |
|
|
"Iron (Fe) is an essential element that is imperative for the redox-
driven processes of oxygen transport, electron transport, and DNA
synthesis.
However, in the absence of appropriate storage or chelation, excess-
free Fe readily participates in the formation of toxic-free radicals,
inducing oxidative stress and apoptosis.
A growing body of evidence suggests that Fe may play some role in"
Just so, when the normal activity of the human body to control iron is
distorted such can happen. The prime question then becomes what causes
this distortion so the resulting iron levels can be avoided. We need
the cause not the result which is the iron levels.
One is at a loss to see the cause in using tobacco, unless the vit b3
some claim it has is the problem? Why then would one follow the subject
line and use tobacco? |
|
| |
|
| Back to top |
Guest
|
| Posted: Tue Nov 11, 2008 1:55 am Post subject: Re: Smoke Em If You Got Em |
|
|
"nicotine"
So is it a form of vit b3 or not? Farmers used to feed horses tobacco
because nicotine is a toxic substance which would kill intestinal worms. |
|
| |
|
| Back to top |
ironjustice@aol.com
Guest
|
| Posted: Tue Nov 11, 2008 1:55 am Post subject: Re: Smoke Em If You Got Em |
|
|
On Nov 10, 1:34 pm, anonym...@nowhere.you.know wrote:snip <<
Been called a whack by EVERYONE it seems .. obviously with good ..
reason ..
Take all those .. whacko .. conclusions your theories AND personality
AND weird .. fkg .. hat .. somewhere OTHER than **my** threads ..
whacko ..
Go update your blogs ..
Iron: a new target for pharmacological intervention in
neurodegenerative diseases.
Semin Pediatr Neurol. 2006 Sep;13(3):186-97.
Whitnall M, Richardson DR.
Iron Metabolism and Chelation Program, Department of Pathology,
University of Sydney, Sydney, New South Wales, Australia.
Iron (Fe) is an essential element that is imperative for the redox-
driven processes of oxygen transport, electron transport, and DNA
synthesis.
However, in the absence of appropriate storage or chelation, excess-
free Fe readily participates in the formation of toxic-free radicals,
inducing oxidative stress and apoptosis.
A growing body of evidence suggests that Fe may play some role in
neurodegenerative diseases such as Huntington disease, Alzheimer>s
disease, Parkinson>s disease, and particularly Friedreich>s ataxia.
This review examines the role of Fe in the pathology of these
conditions and the potential use of Fe chelators as therapeutic
agents for the treatment of neurodegenerative disorders.
Consideration is given to the features that comprise a clinically
successful Fe chelator, with focus on the development of ligands such
as desferrioxamine, clioquinol, pyridoxal isonicotinoyl hydrazone,
and other novel aroylhydrazones.
PMID: 17101458
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
|
| |
|
| Back to top |
Guest
|
| Posted: Tue Nov 11, 2008 1:56 am Post subject: Re: Smoke Em If You Got Em |
|
|
| Here come de broom. |
|
| |
|
| Back to top |
Guest
|
| Posted: Tue Nov 11, 2008 3:34 am Post subject: Re: Smoke Em If You Got Em |
|
|
What we need is better brooms, not tobacco. Vit b3 while useful does
not well clean up this mess. |
|
| |
|
| Back to top |
|
