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ironjustice
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 Posted: Sat Nov 08, 2008 2:26 pm Post subject: Re: Smoke Em If You Got Em |
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On Nov 7, 5:31 pm, "John Hasenkam" <jo...@goawayplease.com> wrote:
These are two different conditions. If they were treating "dementias"
they
would say so, not "Alzheimers". Please explain why smokers have very
high
rates of vascular problems. <<
Increased red blood cell production and lack of antioxidants.
Erythrocytosis causes kidney disease and kidney disease leads to
cognitive impairment.
Kidney Transplantation Can Improve Mental Performance, University of
Pittsburgh Study Finds
11/7/2008
NEW YORK (Reuters Health) - People with kidney disease often suffer
from cognitive impairment, but kidney transplantation can improve
their mental performance, research presented Thursday at the Society
of Nephrology>s annual meeting in Philadelphia confirms.
--------------------------------
(The FASEB Journal. 2007;21:741.8)
© 2007 FASEB This Article
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Articles by Ogunshola, O.
Articles by Gassmann, M.
PubMed
Articles by Ogunshola, O.
Articles by Gassmann, M.
--------------------------------------------------------------------------------
Chronic excessive erythrocytosis increases susceptibility to vascular
damage
Omolara Ogunshola and Max Gassmann
Institute of Veterinary Physiology, University of Zurich,
Winterthurerstrasse 260, Zurich, CH8057, Switzerland
ABSTRACT
Excessive erythrocytosis causes severely increased blood viscosity,
which may have significant detrimental effects on endothelial cells
and vascular endothelial function. Although our erythropoietin-
overexpressing transgenic mouse line (which has a hematocrit of 0.8–
0.9) has no significant increase in brain vascular permeability at 4–5
months of age under normoxic or acute hypoxic conditions, the brain
vascular endothelial cells appeared activated with increased luminal
protrusions reminiscent of ongoing inflammatory processes. Consistent
with this, we detected increased levels of ICAM-1 and von Willebrand
factor, markers of endothelial activation and damage, in brain tissue.
Current data shows that by 9–11 months of age these mice have
significantly increased serum levels of IL-6 and VCAM-1 expression.
Further nuclear NFkB levels are augmented and JNK and ERK/MAPK
pathways are also upregulated. In addition P53 levels are induced and
Bcl-XL levels decreased indicating activated cell death pathways. As
these mice die prematurely we propose that chronic excessive
erythrocytosis results in inflammation and endothelial damage
increasing susceptibility to vascular disease.
Supported by SNF grant 3100AO-112216.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
[quote]
--http://healthycuriousity.blogspot.com/"ironjustice" <ironjust...@cashette.com> wrote in message
news:d0a951d1-020d-4a82-94ea-74f81d71df74@a17g2000prm.googlegroups.com...
On Nov 6, 10:48 pm, "John Hasenkam" <jo...@goawayplease.com> wrote:
Ridiculous, smokers have a much greater risk for vascular dementia.
The
research re smokers and Alz confers a slight advantage but is easily
outweighed by other health risks.
What makes you think this 'Alzheimers' they treated ISN>T vascular
dementia .. ?
Nicotinamide is also called niacin or niacinamide ..
It is used for .. ? .. vascular problems ..
Sooo .. it is coincidence this vitamin is used to treat vascular
problems which cause vascular dementia which **closely** resembles
Alzheimers' .. AND the vitamin is NOW shown to inhibit ..
Alzheimers' ..
Coincidences .. abound ..
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1898481
Niacin in Vascular Disorders and Hyperlipemia
Reviewed by J R A Mitchell
------------
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
--http://healthycuriousity.blogspot.com/"ironjustice"
teamtan...@hotmail.com> wrote in message
news:fd17d3c3-4f77-4cf6-bc7f-b32f07749d7f@l33g2000pri.googlegroups.com....
Sooo .. there isn>t as much loonacy in the theory of nicotine standing
in for nicotinamide as these 'nutritionists' tell you.
People in families predisposed to alzheimers' don>t 'get' alzheimers
if they smoke .. those in the family who DON>T smoke .. DO .. get
alzheimers'.
-------
Vitamin B3 Reduces Alzheimer>s Symptoms, Lesions: Clinical Trial On
Nicotinamide Effect In Alzheimer>s Patients
ScienceDaily (Nov. 5, 2008) — An over-the-counter vitamin in high
doses prevented memory loss in mice with Alzheimer>s disease, and UC
Irvine scientists now are conducting a clinical trial to determine its
effect in humans.
Nicotinamide, a form of vitamin B3, lowered levels of a protein called
phosphorylated tau that leads to the development of tangles, one of
two brain lesions associated with Alzheimer>s disease. The vitamin
also strengthened scaffolding along which information travels in brain
cells, helping to keep neurons alive and further preventing symptoms
in mice genetically wired to develop Alzheimer>s.
"Nicotinamide has a very robust effect on neurons," said Kim Green,
UCI scientist and lead author of the study. "Nicotinamide prevents
loss of cognition in mice with Alzheimer>s disease, and the beauty of
it is we already are moving forward with a clinical trial."
The study appears online Nov. 5 in the Journal of Neuroscience.
Nicotinamide is a water-soluble vitamin sold in health food stores. It
generally is safe but can be toxic in very high doses. Clinical trials
have shown it benefits people with diabetes complications and has anti-
inflammatory properties that may help people with skin conditions.
Nicotinamide belongs to a class of compounds called HDAC inhibitors,
which have been shown to protect the central nervous system in rodent
models of Parkinson>s and Huntington>s diseases and amyotrophic
lateral sclerosis. Clinical trials are underway to learn whether HDAC
inhibitors help ALS and Huntington>s patients.
In the nicotinamide study, Green and his colleague, Frank LaFerla,
added the vitamin to drinking water fed to mice. They tested the
rodents' short-term and long-term memory over time using water-maze
and object-recognition tasks and found that treated Alzheimer>s mice
performed at the same level as normal mice, while untreated
Alzheimer>s mice experienced memory loss.
The nicotinamide, in fact, slightly enhanced cognitive abilities in
normal mice. "This suggests that not only is it good for Alzheimer>s
disease, but if normal people take it, some aspects of their memory
might improve," said LaFerla, UCI neurobiology and behavior professor.
Scientists also found that the nicotinamide-treated animals had
dramatically lower levels of the tau protein that leads to the
Alzheimer>s tangle lesion. The vitamin did not affect levels of the
protein beta amyloid, which clumps in the brain to form plaques, the
second type of Alzheimer>s lesion.
Nicotinamide, they found, led to an increase in proteins that
strengthen microtubules, the scaffolding within brain cells along
which information travels. When this scaffolding breaks down, the
brain cells can die. Neuronal death leads to dementia experienced by
Alzheimer>s patients.
"Microtubules are like highways inside cells. What we>re doing with
nicotinamide is making a wider, more stable highway," Green said. "In
Alzheimer>s disease, this highway breaks down. We are preventing that
from happening."
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk- Hide quoted text -
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ironjustice
Guest
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| Posted: Sat Nov 08, 2008 4:20 pm Post subject: Re: Smoke Em If You Got Em |
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On Nov 8, 7:59 am, anonym...@nowhere.you.know wrote:snip <<
What part of you ain>t welcome on my threads don>t you
understand .. ?
---------
"Nicotinamide lowered levels of phosphorylated tau"
"Neither measurement can discriminate entirely"
"It is concluded that neither measurement of phospho-tau, tau nor
A1-42 in CSF can discriminate entirely between dementia and
cognitively non-disturbed controls or between dementia of different
aetiologies"
Cerebrospinal Fluid Phospho-Tau, Total Tau and -Amyloid1-42 in the
Differentiation between Alzheimer>s Disease and Vascular Dementia
Katarina Näggaa, Johan Gottfriesb, Kaj Blennowc,d, Jan Marcussona
aDepartment of Geriatric Medicine, Linköping University Hospital,
Linköping,
bMedicinal Chemistry, AstraZeneca R&D, Mölndal,
cDepartment of Clinical Neuroscience, Section of Experimental
Neuroscience, University of Göteborg, Sahlgrenska University
Hospital,
Mölndal, and
dThe Medical Research Council, Sweden
Dement Geriatr Cogn Disord 2002;14:183-190 (DOI: 10.1159/000066023)
Abstract
The two most frequently examined biomarkers in the diagnosis of
dementia are cerebrospinal fluid (CSF) tau and -amyloid1-42 (A1-42).
An assay for tau phosphorylated at threonine 181 (phospho-tau) has
recently been developed.
We studied these three markers in patients with possible Alzheimer>s
disease (AD; n = 23), probable AD (n = 50), AD with relevant
cerebrovascular disease (AD with CVD; n = 14), possible vascular
dementia (VaD; n = 39), probable VaD (n = 36), cognitively impaired
(n
= 13) and 27 neurologically healthy controls.
Compared with the controls, tau levels were significantly increased
in
possible AD, probable AD, AD with CVD and probable VaD. A1-42 was
decreased in all dementia groups compared with the controls.
In contrast, phospho-tau levels were increased only in probable AD
compared with the controls.
From the results of the present study, it is concluded that neither
measurement of phospho-tau, tau nor A1-42 in CSF can discriminate
entirely between dementia and cognitively non-disturbed controls or
between dementia of different aetiologies in the clinical diagnostic
procedure.
Copyright © 2002 S. Karger AG, Basel
--------------------------------------------------------------------------------
Katarina Nägga, MD
Department of Geriatric Medicine
Linköping University Hospital
S-581 85 Linköping (Sweden)
Tel. +46 13 224093, Fax +46 13 227389, E-Mail Katarina.Na...@lio.se
Vol. 14, No. 4, 2002
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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ironjustice
Guest
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| Posted: Sat Nov 08, 2008 4:51 pm Post subject: Re: Smoke Em If You Got Em |
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On Nov 6, 7:15 am, Taka <taka0...@gmail.com> wrote:
Or you can just drink beer ! It>s full of B vitamins including
nicotinamide. <<
Orrr .. two pieces of my special bread .. Texas toast .. or in a
sandwich .. or as a side to your soup .. etc ..
It is enriched with vegetable lecithin to allow those B vitamins to be
absorbed at a very high rate ..
If one were to use hemp flour one might think then .. since hemp is
supposed to contain all that is required for life .. then a few pieces
of this bread .. enriched with vegetable lecithin would / could keep
one alive as a staple food .. all by itself ..
That>s theory though ..
Any other requirements would be accomplished by breathing ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
The malts & yeast combination in it is a VitB bomb ...
[quote]Now why are novadays people so deficient in B vitamins that they have
to smoke and drink beer ??? Are more B vitamins needed in the modern
world full of PUFAs, lack of sleep and stress ? To combat and
detoxify the lipid peroxides ...
Taka[/quote] |
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ironjustice
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| Posted: Sat Nov 08, 2008 5:08 pm Post subject: Re: Smoke Em If You Got Em |
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On Nov 6, 8:54 am, ironjustice <ironjust...@cashette.com> wrote:
Are more B vitamins needed in the modern
world full of PUFAs, lack of sleep and stress ? To combat and
detoxify the lipid peroxides ...
Do they say anything about the B vitamins doing that .. AS .. the
'mode of operation' / combat and detoxify the lipid peroxides ? <<
It may .. because it protects from metal toxicity which DOES cause
these peroxides you talk about.
B vitamins have been in controversy for awhile. Some argue "on paper B
vitamins are not antioxidants" .. others argue "in evidence based
medicine B vitamins are antioxidants" .. one argument being since they
don>t add or remove an electron they are technically not antioxidants
and the other argument being they are **metal** chelators .. all of
them.
This plant study seems to give some type of credence to the metal
binding / toxicity .. thesis / theory ..
"Nicotinamide and nicotinic acid increased the defence against heavy
metals"
Increased metal tolerance in Salix by nicotinamide and nicotinic acid
Anna B. Ohlssona, , , Tommy Landbergb, Torkel Berglunda and Maria
Gregerb
aDepartment of Biotechnology, Royal Institute of Technology (KTH),
AlbaNova University Center, SE-106 91 Stockholm, Sweden bDepartment of
Botany, Stockholm University, SE-106 91 Stockholm, Sweden
Received 11 October 2007. Available online 22 April 2008.
Abstract
We have earlier shown that nicotinamide (NIC) and nicotinic acid (NiA)
can induce defence-related metabolism in plant cells; e.g. increase
the level of glutathione. Here we investigated if NIC and NiA could
increase the metal tolerance in metal sensitive clones of Salix
viminalis and whether this would be mediated via increased glutathione
level.
Salix clones, sensitive or tolerant to zinc (Zn), copper (Cu) and
cadmium (Cd) were grown in the presence of heavy metals (Cd, Cu or Zn)
or NIC and NiA as well as in combination.
In addition, the influence of N-acetyl-cystein (NAC) and l-2-
oxothiazolidine 4-carboxylate (OTC), stimulators of reduced
glutathione (GSH) biosynthesis, and the glutathione biosynthesis
inhibitor buthionine sulfoximine (BSO) was analysed. Tolerance was
measured as effects on root and shoot dry weight, and the glutathione
and metal concentrations in the tissues were analysed.
Results showed that NIC and NiA decreased the toxic effects of Cd, Cu
and Zn on growth significantly in sensitive clones, but also to some
extent in tolerant clones. However, the glutathione level and metal
concentration did not change by NIC or NiA addition.
Treatment with NAC, OTC or BSO did not per se influence the
sensitivity to Cd, although the glutathione level increased in the
presence of NAC and OTC and decreased in response to BSO.
The results suggest that NIC and NiA increased the defence against
heavy metals but not via glutathione formation per se.
Keywords: Glutathione; Heavy metal defence; Nicotinamide; Nicotinic
acid; Salix viminalis; Toxicity
Abbreviations: BSO, l-buthionine (S,R)-sulfoximine; GSH, glutathione;
NAC, N-acetyl-cystein; NIC, nicotinamide; NiA, nicotinic acid; OTC,
l-2-oxothiazolidine 4-carboxylate; PARP, poly(ADP-ribose)polymerase;
PC, phytochelatin; ROS, reactive oxygen species
doi:10.1016/j.plaphy.2008.04.004
Copyright © 2008 Elsevier Masson SAS All rights reserved.
Research article
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
[quote]On Nov 6, 7:15 am, Taka <taka0...@gmail.com> wrote:
Are more B vitamins needed in the modern
world full of PUFAs, lack of sleep and stress ? To combat and
detoxify the lipid peroxides ...
BY what .. virtue .. ?
What quality do they have to do that .. ?
Do they say anything about the B vitamins doing that .. AS .. the
'mode of operation' / combat and detoxify the lipid peroxides ?
"Nicotinamide belongs to a class of compounds called HDAC inhibitors"
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
Taka- Hide quoted text -
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ironjustice
Guest
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| Posted: Sat Nov 08, 2008 9:13 pm Post subject: Re: Smoke Em If You Got Em |
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On Nov 8, 12:11 pm, anonym...@nowhere.you.know wrote: snip <<
You>ve been told a number of times to stay off my threads ..
Stay off my threads ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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Guest
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| Posted: Sat Nov 08, 2008 9:59 pm Post subject: Re: Smoke Em If You Got Em |
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| Is tobacco a major source of vit b3? |
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Debs
Guest
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| Posted: Sat Nov 08, 2008 10:21 pm Post subject: Re: Smoke Em If You Got Em |
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And fiber!
Debs
anonymous@nowhere.you.know wrote:
> Is tobacco a major source of vit b3? |
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ironjustice
Guest
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| Posted: Sun Nov 09, 2008 12:30 am Post subject: Re: Smoke Em If You Got Em |
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On Nov 8, 3:35 pm, anonym...@nowhere.you.know wrote:snip <<
You>ve been told a number of times to stay off my threads ..
Stay off my threads ..
You have for a number of years morphed into different disguises to
hawk your aspartame wares .. haven>t ya ...
Been called a whack by EVERYONE it seems .. obviously with good ..
reason ..
Take all those .. whacko .. conclusions your theories AND personality
AND weird .. fkg .. hat .. somewhere OTHER than **my** threads ..
whacko ..
Go update your blogs ..
Your .. busy .. busy .. beautiful .. wonderful .. blogs ..
Understand .. ?
What you do is PROVE your theory ..
Do like Betty did ..
PROVE it ..
Try homeopathy ..
OD .. see if you get .. something ..
What will you .. get .. there .. smart guy ..
Some type of .. illness .. ?
Heh .. heh ..
Stay off my threads ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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ironjustice
Guest
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| Posted: Sun Nov 09, 2008 1:50 am Post subject: Re: Smoke Em If You Got Em |
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On Nov 6, 5:22 am, ironjustice <teamtan...@hotmail.com> wrote:
Sooo .. there isn>t as much loonacy in the theory of nicotine
standing
in for nicotinamide as these 'nutritionists' tell you. <<
"¦Á7 nicotinic acetylcholine receptor (¦Á7 nAChR)"
This .. coincidentally .. is the same receptor being TARGETED in
alzheimers or lack thereof.
"Activation of ¦Á7 nAChR may provide a new therapeutic pathway"
"Reduced by nicotine treatment"
"Inhibition of a7 nAChR in the cells exposed to high ferrous iron"
AJRCMB Articles in Press.
Published on April 12, 2007 as doi:10.1165/rcmb.2006-0240OC
ABSTRACT
New evidence indicates that neural mechanisms can downregulate
acute inflammation.
In these studies, we tested the potential role of the ¦Á7 nicotinic
acetylcholine receptor (¦Á7 nAChR) in a rodent model of
acid-induced acute lung injury.
We first determined that the ¦Á7 nAChR was expressed by
alveolar macrophages and lung epithelial cells.
Then, using an acid-induced acute lung injury mouse model,
we found that nicotine, choline, and PNU-282987
(a specific ¦Á7 nAChR agonist) decreased excess lung water
and lung vascular permeability, and reduced protein
concentration in the bronchoalveolar lavage(BAL).
Deficiency of ¦Á7 nAChR resulted in a 2-fold increase in
excess lung water and lung vascular permeability.
The reduction of proinflammatory cytokines (MIP-2 and
TNF-¦Á) in the BAL with nicotine probably resulted from
the suppression of NF-¦ÊB activation in alveolar macrophages.
The beneficial effect of nicotine was also tested in
rat model of acid-induced acute lung injury in which BAL
protein and RAGE, a marker of type I cell injury, were
reduced by nicotine treatment.
These results indicate that activation of ¦Á7 nAChR may
provide a new therapeutic pathway for the treatment of
acute lung injury.
---------------
Oxidative stress might be a mechanism connected with the
decreased ¦Á7 nicotinic receptor influenced by high-concentration
of fluoride in SH-SY5Y neuroblastoma cells
QIN GAO ; LIU Yan-Jie ; GUAN Zhi-Zhong ;
Abstract
The possible mechanism concerning decreased ¦Á7
nicotinic acetylcholine receptor (nAChR) influenced
by fluorosis was investigated.
SH-SY5Y cells were exposed to fluoride within the
range of 0.05-5 ¦ÌM, or ferrous iron (1-100 pM), a free
radical inducer.
The levels of ¦Á7 nAChR expression, lipid peroxidation
and protein oxidation were detected.
The results showed that both high-concentrations of fluoride
and ferrous iron induced increased levels of lipid peroxidation
and protein oxidation in SH-SY5Y cells with
concentration-dependent manners.
In addition, inhibition of a7 nAChR at protein level was observed
in the cells exposed to high amounts of fluoride or ferrous iron.
Furthermore, a declined value of Bmax in [125I]¦Á-bungarotoxin
binding sites was found in the cells treated with the
high-concentration of fluoride.
Interestingly, antioxidants (vitamin E and glutathione) can attenuate
the inhibition of the receptor induced by fluoride.
These findings suggest that oxidative stress resulted from fluorosis
might directly induce the deficit of a7 nAChR.
Revue / Journal Title
Toxicology in vitro ISSN 0887-2333 CODEN TIVIEQ
Source / Source
2008, vol. 22, no4, pp. 837-843 [7 page(s) (article)]
Langue / Language
Anglais
Editeur / Publisher
Elsevier Science, Oxford, ROYAUME-UNI (1987) (Revue)
Mots-cl¨¦s d>auteur / Author Keywords
Fluoride ; Ferrous iron ; ¦Á7 Nicotinic receptor ; Oxidative stress ;
SH-SY5Y cells ;
Localisation / Location
INIST-CNRS, Cote INIST : 21203, 35400017375834.0020
-----------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
[quote]
People in families predisposed to alzheimers' don>t 'get' alzheimers
if they smoke .. those in the family who DON>T smoke .. DO .. get
alzheimers'.
-------
Vitamin B3 Reduces Alzheimer>s Symptoms, Lesions: Clinical Trial On
Nicotinamide Effect In Alzheimer>s Patients
ScienceDaily (Nov. 5, 2008) -- An over-the-counter vitamin in high
doses prevented memory loss in mice with Alzheimer>s disease, and UC
Irvine scientists now are conducting a clinical trial to determine its
effect in humans.
Nicotinamide, a form of vitamin B3, lowered levels of a protein called
phosphorylated tau that leads to the development of tangles, one of
two brain lesions associated with Alzheimer>s disease. The vitamin
also strengthened scaffolding along which information travels in brain
cells, helping to keep neurons alive and further preventing symptoms
in mice genetically wired to develop Alzheimer>s.
"Nicotinamide has a very robust effect on neurons," said Kim Green,
UCI scientist and lead author of the study. "Nicotinamide prevents
loss of cognition in mice with Alzheimer>s disease, and the beauty of
it is we already are moving forward with a clinical trial."
The study appears online Nov. 5 in the Journal of Neuroscience.
Nicotinamide is a water-soluble vitamin sold in health food stores. It
generally is safe but can be toxic in very high doses. Clinical trials
have shown it benefits people with diabetes complications and has anti-
inflammatory properties that may help people with skin conditions.
Nicotinamide belongs to a class of compounds called HDAC inhibitors,
which have been shown to protect the central nervous system in rodent
models of Parkinson>s and Huntington>s diseases and amyotrophic
lateral sclerosis. Clinical trials are underway to learn whether HDAC
inhibitors help ALS and Huntington>s patients.
In the nicotinamide study, Green and his colleague, Frank LaFerla,
added the vitamin to drinking water fed to mice. They tested the
rodents' short-term and long-term memory over time using water-maze
and object-recognition tasks and found that treated Alzheimer>s mice
performed at the same level as normal mice, while untreated
Alzheimer>s mice experienced memory loss.
The nicotinamide, in fact, slightly enhanced cognitive abilities in
normal mice. "This suggests that not only is it good for Alzheimer>s
disease, but if normal people take it, some aspects of their memory
might improve," said LaFerla, UCI neurobiology and behavior professor.
Scientists also found that the nicotinamide-treated animals had
dramatically lower levels of the tau protein that leads to the
Alzheimer>s tangle lesion. The vitamin did not affect levels of the
protein beta amyloid, which clumps in the brain to form plaques, the
second type of Alzheimer>s lesion.
Nicotinamide, they found, led to an increase in proteins that
strengthen microtubules, the scaffolding within brain cells along
which information travels. When this scaffolding breaks down, the
brain cells can die. Neuronal death leads to dementia experienced by
Alzheimer>s patients.
"Microtubules are like highways inside cells. What we>re doing with
nicotinamide is making a wider, more stable highway," Green said. "In
Alzheimer>s disease, this highway breaks down. We are preventing that
from happening."
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk[/quote] |
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Guest
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| Posted: Sun Nov 09, 2008 2:11 am Post subject: Re: Smoke Em If You Got Em |
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nicotine - tobacco, a toxic poison for humans.
"Nicotinamide - one of two forms of vit b3
So let us ask again, is tobacco a good source of vit b3? Keeping in
mind the subject line and the original post. |
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Guest
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| Posted: Sun Nov 09, 2008 5:35 am Post subject: Re: Smoke Em If You Got Em |
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nicotine - tobacco, a toxic poison for humans.
"Nicotinamide - one of two forms of vit b3
So let us ask again, is tobacco a good source of vit b3? Keeping in
The response:
"Stay off my threads .."
As soon as your false notions are corrected and there is absolutely no
chance someone will be hurt by them. With the kind of foot in mouth
silly mistakes seen in this thread someone needs to come behind and
clean up the mess. |
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ironjustice
Guest
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| Posted: Sun Nov 09, 2008 4:10 pm Post subject: Re: Smoke Em If You Got Em |
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On Nov 6, 7:15 am, Taka <taka0...@gmail.com> wrote:
Or youcan just drink beer ! It>s full of B vitamins including
nicotinamide. The malts & yeast combination in it is a VitB bomb ...
<<
I>m not sure if there is really any difference between non-alcoholic
beer and alcoholic beer but .. I>ve always held .. non-alcoholic beer
should theoretically be very good for you ..
"Consumption of non-alcoholic beer produces a decrease in oxidative
stress that can have a beneficial impact on cardiovascular risk."
Topic: Consumption of Alcohol-Free Beer May Lower Oxidative Stress
Keywords: OXIDATIVE STRESS - Alcohol-Free Beer
Reference: "Effects of alcohol-free beer on lipid profile and
parameters of oxidative stress and inflammation in elderly women,"
Alvarez JR, Codoner-Franch P. et al, Nutrition, 2008 Oct; [Epub ahead
of print]. (Address: Spanish Society of Dietetics and Food Science,
Madrid, Spain).
Summary: In a study involving 29 nuns aged 58 to 73 years, results
indicate that regular consumption of alcohol-free beer may be
associated with decreased oxidative stress. The nuns received 500 mL/
day of alcohol-free beer, with meals, for a period of 45 days. At
intervention end, antibody titers to oxidized low-density lipoprotein
were significantly lower, and thiobarbituric acid-reactive substances
(-18%) and plasma carbonyl group content (-21%) were decreased,
compared with baseline. Additionally, increases in alpha-tocopherol
levels (+9%) and erythrocytic glutathione levels (+29%) were observed.
Thus, the authors of this study conclude, "Consumption of non-
alcoholic beer produces a decrease in oxidative stress that can have a
beneficial impact on cardiovascular risk."
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
[quote]Now why are novadays people so deficient in B vitamins that they have
tosmokeand drink beer ??? Are more B vitamins needed in the modern
world full of PUFAs, lack of sleep and stress ? To combat and
detoxify the lipid peroxides ...
Taka[/quote] |
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Guest
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| Posted: Sun Nov 09, 2008 11:52 pm Post subject: Re: Smoke Em If You Got Em |
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"You have for a number of years morphed into different disguises to
hawk your aspartame wares .. haven>t ya ..."
Getting more paranoid are we? Not me, I have not posted on that product
to the best of my knowledge. Nor have I posted false information
confusing a toxin from tobacco as being a form of vit b3; among other
silly foot in mouth tricks you do on a regular basis. Do you smoke too?
Just because you are paranoid does not mean someone will not be coming
behind you to clean up your mess. |
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ironjustice
Guest
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| Posted: Mon Nov 10, 2008 12:47 am Post subject: Re: Smoke Em If You Got Em |
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On Nov 9, 9:52 am, anonym...@nowhere.you.know wrote:snip <<
You>ve been told a number of times to stay off my threads ..
Stay off my threads ..
You have for a number of years morphed into different disguises to
hawk your aspartame wares .. haven>t ya ...
Been called a whack by EVERYONE it seems .. obviously with good ..
reason ..
Take all those .. whacko .. conclusions your theories AND personality
AND weird .. fkg .. hat .. somewhere OTHER than **my** threads ..
whacko ..
Go update your blogs ..
Your .. busy .. busy .. beautiful .. wonderful .. blogs ..
Understand .. ?
What you do is PROVE your theory ..
Do like Betty did ..
PROVE it ..
Try homeopathy ..
OD .. see if you get .. something ..
What will you .. get .. there .. smart guy ..
Some type of .. illness .. ?
Heh .. heh ..
Stay off my threads ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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ironjustice
Guest
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| Posted: Mon Nov 10, 2008 5:53 am Post subject: Re: Smoke Em If You Got Em |
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On Nov 9, 7:41 pm, anonym...@nowhere.you.know wrote:snip <<
You>ve been told a number of times to stay off my threads .. aspartame
boy ..
Stay off my threads ..
Been called a whack by EVERYONE it seems .. obviously with good ..
reason ..
Take all those .. whacko .. conclusions your theories AND personality
AND weird .. fkg .. hat .. somewhere OTHER than **my** threads ..
whacko ..
Go update your blogs ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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