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 Posted: Wed Nov 26, 2008 10:58 pm Post subject: Rust In Rosacea |
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Oxidative stress and ferritin expression in the skin of patients with
rosacea.
Tisma VS, Basta-Juzbasic A, Jaganjac M, Brcic L, Dobric I, Lipozencic
J, Tatzber F, Zarkovic N, Poljak-Blazi M
J Am Acad Dermatol 2008 Nov 22.
BACKGROUND:
Rosacea is a common chronic light-sensitive inflammatory skin disease
of unknown origin. The purpose of this work was to determine the
parameters of oxidative stress, antioxidative capacity, and the
pathophysiologic role of ferritin expression in skin cells of patients
with rosacea.
OBJECTIVES:
The investigation consisted of measurements of serum peroxide levels,
serum total antioxidative potential levels, and immunohistochemical
analyses of ferritin in skin tissue samples.
RESULTS:
Serum peroxide levels were significantly higher and serum total
antioxidative potential levels were significantly lower in patients
with rosacea than in healthy control subjects (P < .05). Compared with
control subjects, the number of ferritin-positive cells was
significantly higher (P < .001) in skin samples from patients with
rosacea, especially those with severe disease.
LIMITATIONS:
Patients with rosacea in the study were aged 30 to 70 years (average
age was 56 years). Younger patients with flushing only were not
included according to the request of the ethics committee, limiting
the use of diagnostic biopsies only to the necessary cases.
CONCLUSION:
The statistically significant differences in the expression of
ferritin, higher peroxide levels, and lower antioxidative potential
support the onset of systemic oxidative stress in patients with
rosacea.
Journal of the American Academy of Dermatology [J Am Acad Dermatol]
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