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 Posted: Wed Jul 30, 2008 9:53 pm Post subject: Resolving inflammation: dual anti-inflammatory and pro-resol |
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Nat Rev Immunol. 2008 May;8(5):349-61. Links
.Serhan CN, Chiang N, Van Dyke TE.
Center for Experimental Therapeutics and Reperfusion Injury,
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham
and Women>s Hospital and Harvard Medical School, Boston, Massachusetts
02115, USA. cnserhan@zeus.bwh.harvard.edu
Active resolution of acute inflammation is a previously unrecognized
interface between innate and adaptive immunity. Once thought to be a
passive process, the resolution of inflammation is now shown to
involve active biochemical programmes that enable inflamed tissues to
return to homeostasis. This Review presents new cellular and molecular
mechanisms for the resolution of inflammation, revealing key roles for
eicosanoids, such as lipoxins, and recently discovered families of
endogenous chemical mediators, termed resolvins and protectins. These
mediators have anti-inflammatory and pro-resolution properties,
thereby protecting organs from collateral damage, stimulating the
clearance of inflammatory debris and promoting mucosal antimicrobial
defence.
PMID: 18437155 [PubMed - indexed for MEDLINE]
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