Science and Technology news... :: View topic - Question about doxycyxline for periodontitis

dumb_fishie99 · Guest

hi all,

I would like to ask my dentist for a prescription, but then I saw
this:

http://www.drugs.com/mmx/doxycycline-hyclate.html

In which it is stated that:
____________________________________________________________________________
Other actions/effects:

Although doxycycline is a tetracycline antibiotic, systemic
concentrations achieved with this formulation are too low to produce
any antibacterial activity {01}{02}.
__________________________________________________________________________

So if plaque is caused by bacteria, and most dentists
prescribe a very low dose of doxycycline (that is sub-
antimicrobial), then how can this eoplow-dose doxycycline
be of any use?

I know that at 40mg per day, they call it by two other
names, and charge a heck of' a lot more for it, and I
can>t afford those.

Do any dentists actually prescribe regular doxycycline
that is not geared towards people who can afford to be
afraid of super-bugs? If so, how much do they typically
prescribe?

I can afford those $4 walmart and etc. prescriptions,
which are available at 50 mg and 100 mg.

Is a dentist likely to work with me on this, or do they j
ust stick with the super expensive 40mg doxycycline?
I did a google search on "doxycycline dose for
perodontitis" and all the results were for sub-anti-microbial
only.

It just makes no sense to me - plaque is caused by bacteria,
oracea and periostat are too low-dose to have any effect on
bacteria. hey,what?

Your thoughts are appreciated.

dumb_fishie99 · Guest

Well, that is trippin'. I did a google search on that.

Ok, it also sounds expensive, and can only be applied
after one already has an infection, and certainly not to
the whole mouth.

So if low-dose tetracycline doesn;t really work, why
don;t they try higher dose tetracycline, for prevention?

Also on that note, if everyone is so afraid of super-bugs,
why don;t they take the antibiotics out of the meat supply?
I understand I>m far more likely to pick one up from handling
raw meat. I don;t see anybody trying to get the anti-biotics
out of the meat supply, or warning people not to eat meat
because of the bacterial risk. It just seems like there>s
something missing in the thinking process about this.
I read recently that in Europe they did this - they took
the anti-biotics out of the meat supply totally, and the
incidence of super-bugs went way way down.

Ok, so maybe the dentist is not the person to go to
for doxycycline.

dumb_fishie99 · Guest

PS: or do I Just have to go to the dentist exactly every three months
to
make sure?

I jsut read an old post on here that said somethign to that effect.
Only
getting a cleaning every three months has any effect.

I can do this only if I can manage to go to the inexpensive dentist,
and
if the anti-gagging tricks I just learned actually work. I hope they
do.
I alreayd got kicked out of two dentist offices because of it.
I will see how it goes.

Guest

I prescribe tetracycline and doxycycline routinely to my patients.
Many physicians prescribe it for skin problems, arthritis, eye
problems. No one has ever died from tetracycline allergy. It is a
very safe drug compared to penicillin or aspirin. Look at the number
of people who die from aspirin each year.

I believe that periodontal disease is caused by the human body. There
is a decoupling of osteoblasts and osteoclasts working together that
causes bone loss. Some people want to call this the immune
response. Tetracyclines inhibit the osteoclasts. Osteoclasts are
responsible for bone breakdown

Tetracyclines are safe and they prevent bone loss.

WHAT IS THE ROLE OF PLAQUE IN PERIODONTAL DESTRUCTION---i.e. BONE
LOSS?

I am not sure that plaque causes much periodontal disease. This is
a powerful statement. Why?

(1) Periodontal disease does not follow Koch>s postulates and Koch>s
postulates are the foundation for bacteriology.

(2) Periodontal disease is not found in children. Bacteria diseases
are indiscriminant with regard to age.

(3) In diseases that make you more prone to bacterial infections,
e.g.,Sickle cell anemia, periodontal disease is not more common.

(4) The teeth that contain the most plaque, the lower anterior teeth,
are the last teeth to be lost in the mouth. If they contain the most
plaque they should be lost first.

(5) Straight teeth would contain less plaque because they are easier
to clean. No difference is seen in longevity.

(6) Rapid bone loss in young adults is associated with little
inflammation and little plaque.

(7) Tooth Decay does follows Koch>s postulates and is found in
children. Are we wrongly associating plaque with periodontal disease
because of what we know about tooth decay. Is it guilt by
association?

(8) Inflammation vs infection. We wrongly confuse infection with
inflammation.

David DiBenedetto, DMD, author of "Insider>s guide to gum disease,
orthodontics and dentistry. What is not taught in dental school."

dumb_fishie99 · Guest

On Nov 16, 9:23 am, Steven Bornfeld <dentaltwinm...@earthlink.net>
wrote:
[quote]dumb_fishie99 wrote:
hi all,

I would like to ask my dentist for a prescription, but then I saw
this:

http://www.drugs.com/mmx/doxycycline-hyclate.html

In which it is stated that:
____________________________________________________________________________
Other actions/effects:

Althoughdoxycyclineis a tetracycline antibiotic, systemic
concentrations achieved with this formulation are too low to produce
any antibacterial activity {01}{02}.
__________________________________________________________________________

So if plaque is caused by bacteria, and most dentists
prescribe a very low dose ofdoxycycline(that is sub-
antimicrobial), then how can this eoplow-dose doxycycline
be of any use?

I know that at 40mg per day, they call it by two other
names, and charge a heck of' a lot more for it, and I
can>t afford those.

Do any dentists actually prescribe regulardoxycycline
that is not geared towards people who can afford to be
afraid of super-bugs? If so, how much do they typically
prescribe?

I can afford those $4 walmart and etc. prescriptions,
which are available at 50 mg and 100 mg.

Is a dentist likely to work with me on this, or do they j
ust stick with the super expensive 40mgdoxycycline?
I did a google search on "doxycyclinedose for
perodontitis" and all the results were for sub-anti-microbial
only.

It just makes no sense to me - plaque is caused by bacteria,
oracea and periostat are too low-dose to have any effect on
bacteria. hey,what?

Your thoughts are appreciated.

Valid question. The rationale for low-dosedoxycyclineis NOT based on
it>s antibacterial action (you>re right--this is an insufficient dose
for effective antibacterial action), but on this low concentration
nevertheless inhibiting the enzyme collagenase, which has a role in the
breakdown of periodontal tissue.
Nevertheless, most of the periodontists I>ve spoken to are underwhelmed
by the effectiveness of low-dose tetracyclines in periodontal therapy.
Most would prefer to use them (if at all) in locally-delivered dosing,
such as Atridox, which delivers a high local concentration without a
significant systemic dosing.
[/quote]

Hm, further question:

Since perodontitis is caused by bacteria, not by collegenase,
Then why not attack the problem, as though dealing with bacteria?

I looked it up on wikipedia:

http://en.wikipedia.org/wiki/Periodontitis

So I found this mention of collagenase:

[quote]Deep pockets between the teeth and the gums (pockets are sites
where the attachment has been gradually destroyed by collagen-destroying
enzymes, known as collagenases)
[/quote]
You know what, it sounds to me like this idea of using sub-
antimicrobial
dose levels of doxycycline, is meant for AFTER you already got a big
problem!

What about BEFORE you already got a big problem??? Could a stronger
dose of doxycycline help prevent the big problem, along with all the
usual
preventions?

Steven Bornfeld · Guest

dumb_fishie99 wrote:
[quote]hi all,

I would like to ask my dentist for a prescription, but then I saw
this:

http://www.drugs.com/mmx/doxycycline-hyclate.html

In which it is stated that:
____________________________________________________________________________
Other actions/effects:

Although doxycycline is a tetracycline antibiotic, systemic
concentrations achieved with this formulation are too low to produce
any antibacterial activity {01}{02}.
__________________________________________________________________________

So if plaque is caused by bacteria, and most dentists
prescribe a very low dose of doxycycline (that is sub-
antimicrobial), then how can this eoplow-dose doxycycline
be of any use?

I know that at 40mg per day, they call it by two other
names, and charge a heck of' a lot more for it, and I
can>t afford those.

Do any dentists actually prescribe regular doxycycline
that is not geared towards people who can afford to be
afraid of super-bugs? If so, how much do they typically
prescribe?

I can afford those $4 walmart and etc. prescriptions,
which are available at 50 mg and 100 mg.

Is a dentist likely to work with me on this, or do they j
ust stick with the super expensive 40mg doxycycline?
I did a google search on "doxycycline dose for
perodontitis" and all the results were for sub-anti-microbial
only.

It just makes no sense to me - plaque is caused by bacteria,
oracea and periostat are too low-dose to have any effect on
bacteria. hey,what?

Your thoughts are appreciated.

[/quote]
Valid question. The rationale for low-dose doxycycline is NOT based on
it>s antibacterial action (you>re right--this is an insufficient dose
for effective antibacterial action), but on this low concentration
nevertheless inhibiting the enzyme collagenase, which has a role in the
breakdown of periodontal tissue.
Nevertheless, most of the periodontists I>ve spoken to are underwhelmed
by the effectiveness of low-dose tetracyclines in periodontal therapy.
Most would prefer to use them (if at all) in locally-delivered dosing,
such as Atridox, which delivers a high local concentration without a
significant systemic dosing.

Steve

Guest

On Nov 16, 5:46 pm, dumb_fishie99 <dumb_fishi...@yahoo.com> wrote:
[quote]On Nov 16, 9:23 am, Steven Bornfeld <dentaltwinm...@earthlink.net
wrote:

dumb_fishie99 wrote:
hi all,

I would like to ask my dentist for a prescription, but then I saw
this:

http://www.drugs.com/mmx/doxycycline-hyclate.html

In which it is stated that:
____________________________________________________________________________
Other actions/effects:

Althoughdoxycyclineis a tetracycline antibiotic, systemic
concentrations achieved with this formulation are too low to produce
any antibacterial activity {01}{02}.
__________________________________________________________________________

So if plaque is caused by bacteria, and most dentists
prescribe a very low dose ofdoxycycline(that is sub-
antimicrobial), then how can this eoplow-dose doxycycline
be of any use?

I know that at 40mg per day, they call it by two other
names, and charge a heck of' a lot more for it, and I
can>t afford those.

Do any dentists actually prescribe regulardoxycycline
that is not geared towards people who can afford to be
afraid of super-bugs? If so, how much do they typically
prescribe?

I can afford those $4 walmart and etc. prescriptions,
which are available at 50 mg and 100 mg.

Is a dentist likely to work with me on this, or do they j
ust stick with the super expensive 40mgdoxycycline?
I did a google search on "doxycyclinedose for
perodontitis" and all the results were for sub-anti-microbial
only.

It just makes no sense to me - plaque is caused by bacteria,
oracea and periostat are too low-dose to have any effect on
bacteria. hey,what?

Your thoughts are appreciated.

Valid question. The rationale for low-dosedoxycyclineis NOT based on
it>s antibacterial action (you>re right--this is an insufficient dose
for effective antibacterial action), but on this low concentration
nevertheless inhibiting the enzyme collagenase, which has a role in the
breakdown of periodontal tissue.
Nevertheless, most of the periodontists I>ve spoken to are underwhelmed
by the effectiveness of low-dose tetracyclines in periodontal therapy.
Most would prefer to use them (if at all) in locally-delivered dosing,
such as Atridox, which delivers a high local concentration without a
significant systemic dosing.

Hm, further question:

Since perodontitis is caused by bacteria, not by collegenase,
Then why not attack the problem, as though dealing with bacteria?

I looked it up on wikipedia:

http://en.wikipedia.org/wiki/Periodontitis

So I found this mention of collagenase:

Deep pockets between the teeth and the gums (pockets are sites
where the attachment has been gradually destroyed by collagen-destroying
enzymes, known as collagenases)

You know what, it sounds to me like this idea of using sub-
antimicrobial
dose levels of doxycycline, is meant for AFTER you already got a big
problem!

What about BEFORE you already got a big problem??? Could a stronger
dose of doxycycline help prevent the big problem, along with all the
usual
preventions?
[/quote]

You should review (1) periodontosis definition in the the free
dictionary by farlex, "a degenerative, noninflammatory condition of
the periodontium, characterized by destruction of tissue."

This very, very destructive NONINFLAMMATORY condition is treated with
tetracycline. Why? It helps to prevent osteoclasts from destroying
bone.

You might also want to review (2) the definition of pneumonia in
wikipedia, and see how it could resemble periodontal disease. One of
the causes of pneumonia is idiopathic. And, How is pneumonia
treated? With drugs.

Unfortunately, wikipedia definition of periodontal disease is very
simplistic and that is why I wrote my book.

You should also review (3) Koch>s postulates. Periodontal disease
does not follow Koch>s postulates. And then you have to ask why?

David DiBenedetto, DMD

Guest

On Nov 16, 6:51 pm, Steven Bornfeld <dentaltwinm...@earthlink.net>
wrote:
[quote]oralhea...@comcast.net wrote:
I prescribe tetracycline and doxycycline routinely to my patients.
Many physicians prescribe it for skin problems, arthritis, eye
problems. No one has ever died from tetracycline allergy. It is a
very safe drug compared to penicillin or aspirin. Look at the number
of people who die from aspirin each year.

http://www.ncbi.nlm.nih.gov/pubmed/848727

Steve
[/quote]
That occurred in 1977 in India. I think it was an injection. Not
oral administration. Was the tetracycline contaminated?

Dave

Guest

On Nov 16, 6:47 pm, Steven Bornfeld <dentaltwinm...@earthlink.net>
wrote:
[quote]dumb_fishie99 wrote:

Well, that is trippin'. I did a google search on that.

Ok, it also sounds expensive, and can only be applied
after one already has an infection, and certainly not to
the whole mouth.

So if low-dose tetracycline doesn;t really work, why
don;t they try higher dose tetracycline, for prevention?

Also on that note, if everyone is so afraid of super-bugs,
why don;t they take the antibiotics out of the meat supply?
I understand I>m far more likely to pick one up from handling
raw meat. I don;t see anybody trying to get the anti-biotics
out of the meat supply, or warning people not to eat meat
because of the bacterial risk. It just seems like there>s
something missing in the thinking process about this.
I read recently that in Europe they did this - they took
the anti-biotics out of the meat supply totally, and the
incidence of super-bugs went way way down.

Ok, so maybe the dentist is not the person to go to
for doxycycline.

Tetracycline has been used (as well as other antibiotics, such as
metronidazole--nasty stuff) mostly short-term. Using for more than a
couple of weeks invites superinfection (mostly yeast).
Tetracycline is not a first-call antibiotics for most infections
(though it has been used extensively for lyme disease), partially
because of misuse and overuse.
No, you wouldn>t use the locally-applied antibiotics all over the
mouth. Use is generally selective--many periodontists will use it on
periodontal pockets where they are on the fence about doing surgery. In
the best case, it will enable enough improvement so that surgery in a
given area isn>t necessary. Doesn>t always work, but selectivity is the
key here.

Steve
[/quote]
I believe locally applied antibiotics are worthless. You want to
attack the osteoclasts systemically.

Remember osteoclasts destroy the bone by releasing HCl. ONLY
osteoclasts destroy bone.

Inflammation MAY recruit osteoclasts to the area by mediators.

It is ridiculus not to use a cheap, safe medicine to control bone
loss. Is good skin as important as good teeth? Dermatologists use it
to keep skin healthy. I think good teeth is as important as good
skin.

Dave

Guest

You are beneath contempt DiBenedetto.

Your "beliefs" are contrary to all available scientific evidence.

Truly feel remorse for the patients that allow you to mis-treat them.

If there ever was a case for dental malpractice, you are the
poster-boy.

On Sun, 16 Nov 2008 11:11:20 -0800 (PST), oralhealth@comcast.net
wrote:

[quote]No one has ever died from tetracycline allergy.
[/quote]
Bet you can>t prove that, somewhere someone did.
This is a foolish statement that you cannot back up.

[quote]I believe that periodontal disease is caused by the human body.
[/quote]
Your "beliefs" do not matter one Iota.
Scientific evidence says otherwise.

What an idiot !

<PLONK>

Steven Bornfeld · Guest

dumb_fishie99 wrote:
[quote]
Well, that is trippin'. I did a google search on that.

Ok, it also sounds expensive, and can only be applied
after one already has an infection, and certainly not to
the whole mouth.

So if low-dose tetracycline doesn;t really work, why
don;t they try higher dose tetracycline, for prevention?

Also on that note, if everyone is so afraid of super-bugs,
why don;t they take the antibiotics out of the meat supply?
I understand I>m far more likely to pick one up from handling
raw meat. I don;t see anybody trying to get the anti-biotics
out of the meat supply, or warning people not to eat meat
because of the bacterial risk. It just seems like there>s
something missing in the thinking process about this.
I read recently that in Europe they did this - they took
the anti-biotics out of the meat supply totally, and the
incidence of super-bugs went way way down.

Ok, so maybe the dentist is not the person to go to
for doxycycline.

[/quote]

Tetracycline has been used (as well as other antibiotics, such as
metronidazole--nasty stuff) mostly short-term. Using for more than a
couple of weeks invites superinfection (mostly yeast).
Tetracycline is not a first-call antibiotics for most infections
(though it has been used extensively for lyme disease), partially
because of misuse and overuse.
No, you wouldn>t use the locally-applied antibiotics all over the
mouth. Use is generally selective--many periodontists will use it on
periodontal pockets where they are on the fence about doing surgery. In
the best case, it will enable enough improvement so that surgery in a
given area isn>t necessary. Doesn>t always work, but selectivity is the
key here.

Steve

Steven Bornfeld · Guest

dumb_fishie99 wrote:
[quote]PS: or do I Just have to go to the dentist exactly every three months
to
make sure?

I jsut read an old post on here that said somethign to that effect.
Only
getting a cleaning every three months has any effect.

I can do this only if I can manage to go to the inexpensive dentist,
and
if the anti-gagging tricks I just learned actually work. I hope they
do.
I alreayd got kicked out of two dentist offices because of it.
I will see how it goes.
[/quote]

Most periodontists see their patients 3 or 4 times a year, but of
course needed frequency should be determined on an individual basis.
There are ways of dealing with gagging--topical anesthetics. My
brother is experimenting with hypnosis, has been doing extensive reading
and course work. I>ve heard it can be effective for this application
for many patients.

Steve

Steven Bornfeld · Guest

oralhealth@comcast.net wrote:
[quote]I prescribe tetracycline and doxycycline routinely to my patients.
Many physicians prescribe it for skin problems, arthritis, eye
problems. No one has ever died from tetracycline allergy. It is a
very safe drug compared to penicillin or aspirin. Look at the number
of people who die from aspirin each year.
[/quote]
http://www.ncbi.nlm.nih.gov/pubmed/848727

Steve

[quote]
I believe that periodontal disease is caused by the human body. There
is a decoupling of osteoblasts and osteoclasts working together that
causes bone loss. Some people want to call this the immune
response. Tetracyclines inhibit the osteoclasts. Osteoclasts are
responsible for bone breakdown

Tetracyclines are safe and they prevent bone loss.

WHAT IS THE ROLE OF PLAQUE IN PERIODONTAL DESTRUCTION---i.e. BONE
LOSS?

I am not sure that plaque causes much periodontal disease. This is
a powerful statement. Why?

(1) Periodontal disease does not follow Koch>s postulates and Koch>s
postulates are the foundation for bacteriology.

(2) Periodontal disease is not found in children. Bacteria diseases
are indiscriminant with regard to age.

(3) In diseases that make you more prone to bacterial infections,
e.g.,Sickle cell anemia, periodontal disease is not more common.

(4) The teeth that contain the most plaque, the lower anterior teeth,
are the last teeth to be lost in the mouth. If they contain the most
plaque they should be lost first.

(5) Straight teeth would contain less plaque because they are easier
to clean. No difference is seen in longevity.

(6) Rapid bone loss in young adults is associated with little
inflammation and little plaque.

(7) Tooth Decay does follows Koch>s postulates and is found in
children. Are we wrongly associating plaque with periodontal disease
because of what we know about tooth decay. Is it guilt by
association?

(8) Inflammation vs infection. We wrongly confuse infection with
inflammation.

David DiBenedetto, DMD, author of "Insider>s guide to gum disease,
orthodontics and dentistry. What is not taught in dental school."

[/quote]

Steven Bornfeld · Guest

dumb_fishie99 wrote:
[quote]On Nov 16, 9:23 am, Steven Bornfeld <dentaltwinm...@earthlink.net
wrote:
dumb_fishie99 wrote:
hi all,
I would like to ask my dentist for a prescription, but then I saw
this:
http://www.drugs.com/mmx/doxycycline-hyclate.html
In which it is stated that:
____________________________________________________________________________
Other actions/effects:
Althoughdoxycyclineis a tetracycline antibiotic, systemic
concentrations achieved with this formulation are too low to produce
any antibacterial activity {01}{02}.
__________________________________________________________________________
So if plaque is caused by bacteria, and most dentists
prescribe a very low dose ofdoxycycline(that is sub-
antimicrobial), then how can this eoplow-dose doxycycline
be of any use?
I know that at 40mg per day, they call it by two other
names, and charge a heck of' a lot more for it, and I
can>t afford those.
Do any dentists actually prescribe regulardoxycycline
that is not geared towards people who can afford to be
afraid of super-bugs? If so, how much do they typically
prescribe?
I can afford those $4 walmart and etc. prescriptions,
which are available at 50 mg and 100 mg.
Is a dentist likely to work with me on this, or do they j
ust stick with the super expensive 40mgdoxycycline?
I did a google search on "doxycyclinedose for
perodontitis" and all the results were for sub-anti-microbial
only.
It just makes no sense to me - plaque is caused by bacteria,
oracea and periostat are too low-dose to have any effect on
bacteria. hey,what?
Your thoughts are appreciated.
Valid question. The rationale for low-dosedoxycyclineis NOT based on
it>s antibacterial action (you>re right--this is an insufficient dose
for effective antibacterial action), but on this low concentration
nevertheless inhibiting the enzyme collagenase, which has a role in the
breakdown of periodontal tissue.
Nevertheless, most of the periodontists I>ve spoken to are underwhelmed
by the effectiveness of low-dose tetracyclines in periodontal therapy.
Most would prefer to use them (if at all) in locally-delivered dosing,
such as Atridox, which delivers a high local concentration without a
significant systemic dosing.

Hm, further question:

Since perodontitis is caused by bacteria, not by collegenase,
Then why not attack the problem, as though dealing with bacteria?

I looked it up on wikipedia:

http://en.wikipedia.org/wiki/Periodontitis

So I found this mention of collagenase:

Deep pockets between the teeth and the gums (pockets are sites
where the attachment has been gradually destroyed by collagen-destroying
enzymes, known as collagenases)

You know what, it sounds to me like this idea of using sub-
antimicrobial
dose levels of doxycycline, is meant for AFTER you already got a big
problem!

What about BEFORE you already got a big problem??? Could a stronger
dose of doxycycline help prevent the big problem, along with all the
usual
preventions?

[/quote]

My periodontists as a group take a fairly dim view of low-dose
tetracycline therapy. The amount of improvement cited was not exciting.
Yes, bacterial control is the key. But in the absence of ideal oral
hygiene, and esp. in the presence of periodontal pockets that are ideal
breeding grounds for anaerobic and facultative organisms implicated in
periodontal disease, you>d have to be on antibiotics long-term. This is
not practical.
Makes much more sense to practice excellent oral hygiene. If
periodontal pockets are present, pocket elimination therapy will be
necessary to make adequate oral hygiene possible.
This is an old paradigm; it is very attractive to think there is a
magic pill to prevent periodontal disease. I haven>t seen one.

Steve

dumb_fishie99 · Guest

On Nov 16, 4:39 pm, oralhea...@comcast.net wrote:
[quote]On Nov 16, 6:47 pm, Steven Bornfeld <dentaltwinm...@earthlink.net
wrote:

dumb_fishie99 wrote:

Well, that is trippin'. I did a google search on that.

Ok, it also sounds expensive, and can only be applied
after one already has an infection, and certainly not to
the whole mouth.

So if low-dose tetracycline doesn;t really work, why
don;t they try higher dose tetracycline, for prevention?

Also on that note, if everyone is so afraid of super-bugs,
why don;t they take the antibiotics out of the meat supply?
I understand I>m far more likely to pick one up from handling
raw meat. I don;t see anybody trying to get the anti-biotics
out of the meat supply, or warning people not to eat meat
because of the bacterial risk. It just seems like there>s
something missing in the thinking process about this.
I read recently that in Europe they did this - they took
the anti-biotics out of the meat supply totally, and the
incidence of super-bugs went way way down.

Ok, so maybe the dentist is not the person to go to
for doxycycline.

Tetracycline has been used (as well as other antibiotics, such as
metronidazole--nasty stuff) mostly short-term. Using for more than a
couple of weeks invites superinfection (mostly yeast).
Tetracycline is not a first-call antibiotics for most infections
(though it has been used extensively for lyme disease), partially
because of misuse and overuse.
No, you wouldn>t use the locally-applied antibiotics all over the
mouth. Use is generally selective--many periodontists will use it on
periodontal pockets where they are on the fence about doing surgery. In
the best case, it will enable enough improvement so that surgery in a
given area isn>t necessary. Doesn>t always work, but selectivity is the
key here.

Steve

I believe locally applied antibiotics are worthless. You want to
attack the osteoclasts systemically.

Remember osteoclasts destroy the bone by releasing HCl. ONLY
osteoclasts destroy bone.
[/quote]
Well I don>t know what HCI is, or osteoclasts.

[quote]
Inflammation MAY recruit osteoclasts to the area by mediators.

It is ridiculus not to use a cheap, safe medicine to control bone
loss. Is good skin as important as good teeth? Dermatologists use it
to keep skin healthy. I think good teeth is as important as good
skin.
[/quote]

That actually makes sense to me.


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