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ironjustice
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 Posted: Thu Nov 27, 2008 5:09 am Post subject: Pufa Prevents Paranoia |
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"With or without the omega-3 fatty acid alpha-linolenic acid"
Chronic risperidone treatment preferentially increases rat erythrocyte
and prefrontal cortex omega-3 fatty acid composition: Evidence for
augmented biosynthesis
Schizophrenia Research, In Press, Corrected Proof, Available online 7
November 2008
Robert K. McNamara, Jessica A. Able, Ronald Jandacek, Therese Rider,
Patrick Tso
Abstract
Prior clinical studies suggest that chronic treatment with atypical
antipsychotic medications increase erythrocyte and postmortem
prefrontal cortex (PFC) omega-3 fatty acid composition in patients
with schizophrenia (SZ).
However, because human tissue phospholipid omega-3 fatty acid
composition is potentially influenced by multiple extraneous
variables, definitive evaluation of this putative mechanism of action
requires an animal model.
In the present study, we determined the effects of chronic treatment
with the atypical antipsychotic risperidone (RISP, 3.0 mg/kg/d) on
erythrocyte and PFC omega-3 fatty acid composition in rats maintained
on a diet with or without the dietary omega-3 fatty acid precursor,
alpha-linolenic acid (ALA, 18:3n-3).
Chronic RISP treatment resulted in therapeutically-relevant plasma
RISP and 9-OH-RISP concentrations (18 ± 2.6 ng/ml), and significantly
increased erythrocyte docosahexaenoic acid (DHA, 22:6n-3, + 22%, p 0.0003) and docosapentaenoic acid (22:5n-3, + 18%, p = 0.01)
composition, and increased PFC DHA composition (+ 7%, p = 0.03) in
rats maintained on the ALA+ diet.
In contrast, chronic RISP did not alter erythrocyte or PFC omega-3
fatty acid composition in rats maintained on the ALA- diet.
Chronic RISP treatment did not alter erythrocyte or PFC arachidonic
acid (AA, 20:4n-6) composition.
These data suggest that chronic RISP treatment significantly augments
ALA-DHA biosynthesis, and preferentially increases peripheral and
central membrane omega-3 fatty acid composition.
Augmented omega-3 fatty acid biosynthesis and membrane composition
represents a novel mechanism of action that may contribute in part to
the efficacy of RISP in the treatment of SZ.]
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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ironjustice@aol.com
Guest
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| Posted: Thu Nov 27, 2008 4:03 pm Post subject: Re: Pufa Prevents Paranoia |
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On Nov 26, 9:09 pm, ironjustice <ironjust...@cashette.com> wrote:"With
or without the omega-3 fatty acid alpha-linolenic acid" <<
Now if one wishes to believe Udo Urasmus one of the leading lipid
researchers then this fatty acid is ONLY found in plants and ONLY
available to you BY eating .. plants.
The oils found in animals are the OTHER fatty acids which are FROM
this plant fatty acid and the acids found in animals DO NOT 'become'
this plant fatty acid .. alpha-linolenic acid.
THAT is the .. key .. ?
This plant fatty acid BECOMES the required fatty acids as evidenced in
the rat study which showed NO production of the fatty acids UNLESS the
plant fatty acid was INCLUDED with the drug.
"RISP did not alter omega-3 fatty acid on the ALA- diet."
Voila .. ?
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
[quote]"With or without the omega-3 fatty acid alpha-linolenic acid"
Chronic risperidone treatment preferentially increases rat erythrocyte
and prefrontal cortex omega-3 fatty acid composition: Evidence for
augmented biosynthesis
Schizophrenia Research, In Press, Corrected Proof, Available online 7
November 2008
Robert K. McNamara, Jessica A. Able, Ronald Jandacek, Therese Rider,
Patrick Tso
Abstract
Prior clinical studies suggest that chronic treatment with atypical
antipsychotic medications increase erythrocyte and postmortem
prefrontal cortex (PFC) omega-3 fatty acid composition in patients
with schizophrenia (SZ).
However, because human tissue phospholipid omega-3 fatty acid
composition is potentially influenced by multiple extraneous
variables, definitive evaluation of this putative mechanism of action
requires an animal model.
In the present study, we determined the effects of chronic treatment
with the atypical antipsychotic risperidone (RISP, 3.0 mg/kg/d) on
erythrocyte and PFC omega-3 fatty acid composition in rats maintained
on a diet with or without the dietary omega-3 fatty acid precursor,
alpha-linolenic acid (ALA, 18:3n-3).
Chronic RISP treatment resulted in therapeutically-relevant plasma
RISP and 9-OH-RISP concentrations (18 ± 2.6 ng/ml), and significantly
increased erythrocyte docosahexaenoic acid (DHA, 22:6n-3, + 22%, p > 0.0003) and docosapentaenoic acid (22:5n-3, + 18%, p = 0.01)
composition, and increased PFC DHA composition (+ 7%, p = 0.03) in
rats maintained on the ALA+ diet.
In contrast, chronic RISP did not alter erythrocyte or PFC omega-3
fatty acid composition in rats maintained on the ALA- diet.
Chronic RISP treatment did not alter erythrocyte or PFC arachidonic
acid (AA, 20:4n-6) composition.
These data suggest that chronic RISP treatment significantly augments
ALA-DHA biosynthesis, and preferentially increases peripheral and
central membrane omega-3 fatty acid composition.
Augmented omega-3 fatty acid biosynthesis and membrane composition
represents a novel mechanism of action that may contribute in part to
the efficacy of RISP in the treatment of SZ.]
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk[/quote] |
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ironjustice@aol.com
Guest
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| Posted: Thu Nov 27, 2008 4:07 pm Post subject: Re: Pufa Prevents Paranoia |
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On Nov 27, 7:49 am, anonym...@nowhere.you.know wrote:
snip <<
You have been told not to post to my threads dioxin boy ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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ironjustice@aol.com
Guest
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| Posted: Thu Nov 27, 2008 4:16 pm Post subject: Re: Pufa Prevents Paranoia |
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On Nov 27, 8:03 am, "ironjust...@aol.com" <ironjust...@aol.com>
wrote:The oils found in animals are the OTHER fatty acids which are
FROM
this plant fatty acid and the acids found in animals DO NOT 'become'
this plant fatty acid .. alpha-linolenic acid. <<
Fatty acids again shown to aid children with behavior problems
Researchers reported last year that supplementation with essential
fatty acids can dramatically accelerate learning and reduce behavior
problems in children with developmental coordination disorder (see
related article, Crime Times, 2005, Vol. 11, No. 3, Page 1). A newer
study indicates that these nutrients can benefit children with
attention deficit hyperactivity disorder (ADHD) as well.
In the new study, Kalpana Joshi and colleagues used flax oil, which is
high in the fatty acid alpha linolenic acid (ALA)-a precursor to the
essential fatty acid docosahexaenoic acid (DHA). The researchers gave
flax oil supplements to 30 children with ADHD along with supplemental
vitamin C, which inhibits harmful fatty acid peroxidation. They
report, "There was significant improvement in the symptoms of ADHD
reflected by reduction in total hyperactivity scores of ADHD children
derived from ADHD rating scales." The children>s social functioning
and learning improved, and they exhibited marked reductions in
impulsivity, restlessness, inattention, self-control problems, and
psychosomatic problems.
-----
"Supplementation with flax oil and vitamin C improves the outcome of
attention deficit hyperactivity disorder (ADHD)," Kalpana Joshi, Sagar
Lad, Mrudula Kale, Bhushan Patwardhan, Sahebrao P. Mahadik, Bindu
Patni, Arti Chaudhary, Sheila Bhave, and Anand Pandit, Prostaglandins,
Leukotrienes and Essential Fatty Acids, November 25, 2005 (epub ahead
of print publication). Address: Kalpana Joshi, Interdisciplinary
School of Health Sciences (ISHS), University of Pune, Ganeshkhind,
Pune-411007, Maharashtra, India, kalpana@unipune.ernet.in.
Related Article: [2006, Vol. 12]
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
[quote]On Nov 26, 9:09 pm, ironjustice <ironjust...@cashette.com> wrote:"With
or without the omega-3 fatty acid alpha-linolenic acid"
Now if one wishes to believe Udo Urasmus one of the leading lipid
researchers then this fatty acid is ONLY found in plants and ONLY
available to you BY eating .. plants.
The oils found in animals are the OTHER fatty acids which are FROM
this plant fatty acid and the acids found in animals DO NOT 'become'
this plant fatty acid .. alpha-linolenic acid.
THAT is the .. key .. ?
This plant fatty acid BECOMES the required fatty acids as evidenced in
the rat study which showed NO production of the fatty acids UNLESS the
plant fatty acid was INCLUDED with the drug.
"RISP did not alter omega-3 fatty acid on the ALA- diet."
Voila .. ?
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk> "With or without the omega-3 fatty acid alpha-linolenic acid"
Chronic risperidone treatment preferentially increases rat erythrocyte
and prefrontal cortex omega-3 fatty acid composition: Evidence for
augmented biosynthesis
Schizophrenia Research, In Press, Corrected Proof, Available online 7
November 2008
Robert K. McNamara, Jessica A. Able, Ronald Jandacek, Therese Rider,
Patrick Tso
Abstract
Prior clinical studies suggest that chronic treatment with atypical
antipsychotic medications increase erythrocyte and postmortem
prefrontal cortex (PFC) omega-3 fatty acid composition in patients
with schizophrenia (SZ).
However, because human tissue phospholipid omega-3 fatty acid
composition is potentially influenced by multiple extraneous
variables, definitive evaluation of this putative mechanism of action
requires an animal model.
In the present study, we determined the effects of chronic treatment
with the atypical antipsychotic risperidone (RISP, 3.0 mg/kg/d) on
erythrocyte and PFC omega-3 fatty acid composition in rats maintained
on a diet with or without the dietary omega-3 fatty acid precursor,
alpha-linolenic acid (ALA, 18:3n-3).
Chronic RISP treatment resulted in therapeutically-relevant plasma
RISP and 9-OH-RISP concentrations (18 ± 2.6 ng/ml), and significantly
increased erythrocyte docosahexaenoic acid (DHA, 22:6n-3, + 22%, p > > 0.0003) and docosapentaenoic acid (22:5n-3, + 18%, p = 0.01)
composition, and increased PFC DHA composition (+ 7%, p = 0.03) in
rats maintained on the ALA+ diet.
In contrast, chronic RISP did not alter erythrocyte or PFC omega-3
fatty acid composition in rats maintained on the ALA- diet.
Chronic RISP treatment did not alter erythrocyte or PFC arachidonic
acid (AA, 20:4n-6) composition.
These data suggest that chronic RISP treatment significantly augments
ALA-DHA biosynthesis, and preferentially increases peripheral and
central membrane omega-3 fatty acid composition.
Augmented omega-3 fatty acid biosynthesis and membrane composition
represents a novel mechanism of action that may contribute in part to
the efficacy of RISP in the treatment of SZ.]
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk[/quote] |
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ironjustice@aol.com
Guest
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| Posted: Thu Nov 27, 2008 4:20 pm Post subject: Re: Pufa Prevents Paranoia |
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On Nov 27, 8:16 am, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
Risperidone <<
Neuropsychiatr Dis Treat. 2008 February; 4(1): 203-207.
Published online 2008 February. PMCID: PMC2515893
Risperidone treatment for ADHD in children and adolescents with
bipolar disorder
Joseph Biederman, Paul Hammerness, Robert Doyle, Gagan Joshi, Megan
Aleardi, and Eric Mick
Pediatric Psychopharmacology Research Department, Massachusetts
General Hospital, Boston, MA, USA
Correspondence: Joseph Biederman Warren 705, Massachusetts General
Hospital, Pediatric Psychopharmacology Research, 55 Fruit St., Boston,
MA. 02114, USA Tel +1 617 724 0956 Fax +1 617 726 1743 Email
jbiederman@partners.org
Abstract
Objective
Children and adolescents with bipolar disorder are also at high risk
of having comorbid attention-deficit hyperactivity disorder (ADHD).
The objective of this study was to estimate improvement in ADHD
symptoms in children with bipolar disorder.
Methods
This was an open-label, study of risperidone monotherapy for the
treatment of pediatric bipolar disorder. Thirty-one children and
adolescents 4-15 years of age (7.2 ¡À 2.8 years) of both sexes (71%, N
= 22 male) with pediatric bipolar disorder (YMRS score = 32.9 ¡À 8.8)
and ADHD (ADHD-RS score = 37.9 ¡À 8.9) were included in these analyses.
Results
Improvement in ADHD symptoms was contingent on improvement in manic
symptoms. Although both hyperactive/impulsive (-7.5 ¡À 5.5.6, p < 0.05)
and inattentive (-6.8 ¡À 5.0, p < 0.05) ADHD symptoms were
significantly improved with risperidone, improvement was modest, and
only 29% of subjects (N = 6) showed a 30% reduction in ADHD rating
scale scores and had a CGI-I ¡Ü 2.
Conclusions
These results suggest that that treatment with risperidone is
associated with tangible but generally modest improvement of symptoms
of ADHD in children with bipolar disorder.
Keywords: ADHD, bipolar disorder, children, risperidone
Copyright (c) 2008 Biederman et al, publisher and licensee Dove Medical
Press Ltd.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
[quote]On Nov 27, 8:03 am, "ironjust...@aol.com" <ironjust...@aol.com
wrote:The oils found in animals are the OTHER fatty acids which are
FROM
this plant fatty acid and the acids found in animals DO NOT 'become'
this plant fatty acid .. alpha-linolenic acid.
Fatty acids again shown to aid children with behavior problems
Researchers reported last year that supplementation with essential
fatty acids can dramatically accelerate learning and reduce behavior
problems in children with developmental coordination disorder (see
related article, Crime Times, 2005, Vol. 11, No. 3, Page 1). A newer
study indicates that these nutrients can benefit children with
attention deficit hyperactivity disorder (ADHD) as well.
In the new study, Kalpana Joshi and colleagues used flax oil, which is
high in the fatty acid alpha linolenic acid (ALA)-a precursor to the
essential fatty acid docosahexaenoic acid (DHA). The researchers gave
flax oil supplements to 30 children with ADHD along with supplemental
vitamin C, which inhibits harmful fatty acid peroxidation. They
report, "There was significant improvement in the symptoms of ADHD
reflected by reduction in total hyperactivity scores of ADHD children
derived from ADHD rating scales." The children>s social functioning
and learning improved, and they exhibited marked reductions in
impulsivity, restlessness, inattention, self-control problems, and
psychosomatic problems.
-----
"Supplementation with flax oil and vitamin C improves the outcome of
attention deficit hyperactivity disorder (ADHD)," Kalpana Joshi, Sagar
Lad, Mrudula Kale, Bhushan Patwardhan, Sahebrao P. Mahadik, Bindu
Patni, Arti Chaudhary, Sheila Bhave, and Anand Pandit, Prostaglandins,
Leukotrienes and Essential Fatty Acids, November 25, 2005 (epub ahead
of print publication). Address: Kalpana Joshi, Interdisciplinary
School of Health Sciences (ISHS), University of Pune, Ganeshkhind,
Pune-411007, Maharashtra, India, kalp...@unipune.ernet.in.
Related Article: [2006, Vol. 12]
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
On Nov 26, 9:09 pm, ironjustice <ironjust...@cashette.com> wrote:"With
or without the omega-3 fatty acid alpha-linolenic acid"
Now if one wishes to believe Udo Urasmus one of the leading lipid
researchers then this fatty acid is ONLY found in plants and ONLY
available to you BY eating .. plants.
The oils found in animals are the OTHER fatty acids which are FROM
this plant fatty acid and the acids found in animals DO NOT 'become'
this plant fatty acid .. alpha-linolenic acid.
THAT is the .. key .. ?
This plant fatty acid BECOMES the required fatty acids as evidenced in
the rat study which showed NO production of the fatty acids UNLESS the
plant fatty acid was INCLUDED with the drug.
"RISP did not alter omega-3 fatty acid on the ALA- diet."
Voila .. ?
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk> "With or without the omega-3 fatty acid alpha-linolenic acid"
Chronic risperidone treatment preferentially increases rat erythrocyte
and prefrontal cortex omega-3 fatty acid composition: Evidence for
augmented biosynthesis
Schizophrenia Research, In Press, Corrected Proof, Available online 7
November 2008
Robert K. McNamara, Jessica A. Able, Ronald Jandacek, Therese Rider,
Patrick Tso
Abstract
Prior clinical studies suggest that chronic treatment with atypical
antipsychotic medications increase erythrocyte and postmortem
prefrontal cortex (PFC) omega-3 fatty acid composition in patients
with schizophrenia (SZ).
However, because human tissue phospholipid omega-3 fatty acid
composition is potentially influenced by multiple extraneous
variables, definitive evaluation of this putative mechanism of action
requires an animal model.
In the present study, we determined the effects of chronic treatment
with the atypical antipsychotic risperidone (RISP, 3.0 mg/kg/d) on
erythrocyte and PFC omega-3 fatty acid composition in rats maintained
on a diet with or without the dietary omega-3 fatty acid precursor,
alpha-linolenic acid (ALA, 18:3n-3).
Chronic RISP treatment resulted in therapeutically-relevant plasma
RISP and 9-OH-RISP concentrations (18 ¡À 2.6 ng/ml), and significantly
increased erythrocyte docosahexaenoic acid (DHA, 22:6n-3, + 22%, p > > > 0.0003) and docosapentaenoic acid (22:5n-3, + 18%, p = 0.01)
composition, and increased PFC DHA composition (+ 7%, p = 0.03) in
rats maintained on the ALA+ diet.
In contrast, chronic RISP did not alter erythrocyte or PFC omega-3
fatty acid composition in rats maintained on the ALA- diet.
Chronic RISP treatment did not alter erythrocyte or PFC arachidonic
acid (AA, 20:4n-6) composition.
These data suggest that chronic RISP treatment significantly augments
ALA-DHA biosynthesis, and preferentially increases peripheral and
central membrane omega-3 fatty acid composition.
Augmented omega-3 fatty acid biosynthesis and membrane composition
represents a novel mechanism of action that may contribute in part to
the efficacy of RISP in the treatment of SZ.]
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk- Hide quoted text -
- Show quoted text -[/quote] |
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ironjustice@aol.com
Guest
|
| Posted: Thu Nov 27, 2008 4:29 pm Post subject: Re: Pufa Prevents Paranoia |
|
|
On Nov 27, 8:20 am, "ironjust...@aol.com" <ironjust...@aol.com>
wrote:ADHD symptoms were significantly improved with risperidone,
improvement was modest, and only 29% of subjects (N = 6) showed a 30%
reduction in ADHD rating
scale scores <<
"RISP Risperidone did not alter omega-3 fatty acid on the ALA- diet."
Kinda makes one wonder what the results would be if they INCLUDED this
alpha-linolenic in those people with ADHD or bi-polar or
schizophrenia .. ?
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
[quote]On Nov 27, 8:16 am, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
Risperidone
Neuropsychiatr Dis Treat. 2008 February; 4(1): 203-207.
Published online 2008 February. PMCID: PMC2515893
Risperidone treatment for ADHD in children and adolescents with
bipolar disorder
Joseph Biederman, Paul Hammerness, Robert Doyle, Gagan Joshi, Megan
Aleardi, and Eric Mick
Pediatric Psychopharmacology Research Department, Massachusetts
General Hospital, Boston, MA, USA
Correspondence: Joseph Biederman Warren 705, Massachusetts General
Hospital, Pediatric Psychopharmacology Research, 55 Fruit St., Boston,
MA. 02114, USA Tel +1 617 724 0956 Fax +1 617 726 1743 Email
jbieder...@partners.org
Abstract
Objective
Children and adolescents with bipolar disorder are also at high risk
of having comorbid attention-deficit hyperactivity disorder (ADHD).
The objective of this study was to estimate improvement in ADHD
symptoms in children with bipolar disorder.
Methods
This was an open-label, study of risperidone monotherapy for the
treatment of pediatric bipolar disorder. Thirty-one children and
adolescents 4-15 years of age (7.2 ¡À 2.8 years) of both sexes (71%, N
= 22 male) with pediatric bipolar disorder (YMRS score = 32.9 ¡À 8.8)
and ADHD (ADHD-RS score = 37.9 ¡À 8.9) were included in these analyses.
Results
Improvement in ADHD symptoms was contingent on improvement in manic
symptoms. Although both hyperactive/impulsive (-7.5 ¡À 5.5.6, p < 0.05)
and inattentive (-6.8 ¡À 5.0, p < 0.05) ADHD symptoms were
significantly improved with risperidone, improvement was modest, and
only 29% of subjects (N = 6) showed a 30% reduction in ADHD rating
scale scores and had a CGI-I ¡Ü 2.
Conclusions
These results suggest that that treatment with risperidone is
associated with tangible but generally modest improvement of symptoms
of ADHD in children with bipolar disorder.
Keywords: ADHD, bipolar disorder, children, risperidone
Copyright (c) 2008 Biederman et al, publisher and licensee Dove Medical
Press Ltd.
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
On Nov 27, 8:03 am, "ironjust...@aol.com" <ironjust...@aol.com
wrote:The oils found in animals are the OTHER fatty acids which are
FROM
this plant fatty acid and the acids found in animals DO NOT 'become'
this plant fatty acid .. alpha-linolenic acid.
Fatty acids again shown to aid children with behavior problems
Researchers reported last year that supplementation with essential
fatty acids can dramatically accelerate learning and reduce behavior
problems in children with developmental coordination disorder (see
related article, Crime Times, 2005, Vol. 11, No. 3, Page 1). A newer
study indicates that these nutrients can benefit children with
attention deficit hyperactivity disorder (ADHD) as well.
In the new study, Kalpana Joshi and colleagues used flax oil, which is
high in the fatty acid alpha linolenic acid (ALA)-a precursor to the
essential fatty acid docosahexaenoic acid (DHA). The researchers gave
flax oil supplements to 30 children with ADHD along with supplemental
vitamin C, which inhibits harmful fatty acid peroxidation. They
report, "There was significant improvement in the symptoms of ADHD
reflected by reduction in total hyperactivity scores of ADHD children
derived from ADHD rating scales." The children>s social functioning
and learning improved, and they exhibited marked reductions in
impulsivity, restlessness, inattention, self-control problems, and
psychosomatic problems.
-----
"Supplementation with flax oil and vitamin C improves the outcome of
attention deficit hyperactivity disorder (ADHD)," Kalpana Joshi, Sagar
Lad, Mrudula Kale, Bhushan Patwardhan, Sahebrao P. Mahadik, Bindu
Patni, Arti Chaudhary, Sheila Bhave, and Anand Pandit, Prostaglandins,
Leukotrienes and Essential Fatty Acids, November 25, 2005 (epub ahead
of print publication). Address: Kalpana Joshi, Interdisciplinary
School of Health Sciences (ISHS), University of Pune, Ganeshkhind,
Pune-411007, Maharashtra, India, kalp...@unipune.ernet.in.
Related Article: [2006, Vol. 12]
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
On Nov 26, 9:09 pm, ironjustice <ironjust...@cashette.com> wrote:"With
or without the omega-3 fatty acid alpha-linolenic acid"
Now if one wishes to believe Udo Urasmus one of the leading lipid
researchers then this fatty acid is ONLY found in plants and ONLY
available to you BY eating .. plants.
The oils found in animals are the OTHER fatty acids which are FROM
this plant fatty acid and the acids found in animals DO NOT 'become'
this plant fatty acid .. alpha-linolenic acid.
THAT is the .. key .. ?
This plant fatty acid BECOMES the required fatty acids as evidenced in
the rat study which showed NO production of the fatty acids UNLESS the
plant fatty acid was INCLUDED with the drug.
"RISP did not alter omega-3 fatty acid on the ALA- diet."
Voila .. ?
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk> "With or without the omega-3 fatty acid alpha-linolenic acid"
Chronic risperidone treatment preferentially increases rat erythrocyte
and prefrontal cortex omega-3 fatty acid composition: Evidence for
augmented biosynthesis
Schizophrenia Research, In Press, Corrected Proof, Available online 7
November 2008
Robert K. McNamara, Jessica A. Able, Ronald Jandacek, Therese Rider,
Patrick Tso
Abstract
Prior clinical studies suggest that chronic treatment with atypical
antipsychotic medications increase erythrocyte and postmortem
prefrontal cortex (PFC) omega-3 fatty acid composition in patients
with schizophrenia (SZ).
However, because human tissue phospholipid omega-3 fatty acid
composition is potentially influenced by multiple extraneous
variables, definitive evaluation of this putative mechanism of action
requires an animal model.
In the present study, we determined the effects of chronic treatment
with the atypical antipsychotic risperidone (RISP, 3.0 mg/kg/d) on
erythrocyte and PFC omega-3 fatty acid composition in rats maintained
on a diet with or without the dietary omega-3 fatty acid precursor,
alpha-linolenic acid (ALA, 18:3n-3).
Chronic RISP treatment resulted in therapeutically-relevant plasma
RISP and 9-OH-RISP concentrations (18 ¡À 2.6 ng/ml), and significantly
increased erythrocyte docosahexaenoic acid (DHA, 22:6n-3, + 22%, p > > > > 0.0003) and docosapentaenoic acid (22:5n-3, + 18%, p = 0.01)
composition, and increased PFC DHA composition (+ 7%, p = 0.03) in
rats maintained on the ALA+ diet.
In contrast, chronic RISP did not alter erythrocyte or PFC omega-3
fatty acid composition in rats maintained on the ALA- diet.
Chronic RISP treatment did not alter erythrocyte or PFC arachidonic
acid (AA, 20:4n-6) composition.
These data suggest that chronic RISP treatment significantly augments
ALA-DHA biosynthesis, and preferentially increases peripheral and
central membrane omega-3 fatty acid composition.
Augmented omega-3 fatty acid biosynthesis and membrane composition
represents a novel mechanism of action that may contribute in part to
the efficacy of RISP in the treatment of SZ.]
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk-Hide quoted text -
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ironjustice@aol.com
Guest
|
| Posted: Thu Nov 27, 2008 5:17 pm Post subject: Re: Pufa Prevents Paranoia |
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|
On Nov 27, 8:29 am, "ironjust...@aol.com" <ironjust...@aol.com>
wrote:"RISP Risperidone did not alter omega-3 fatty acid on the ALA-
diet." <<
http://www.modernforager.com
"Delta-5 desaturase is inhibited by EPA , meaning that the body works
to slow down EPA production when EPA is high. High levels of omega-6
in the diet can also affect the conversions.
Animal fat, transfat and excessive omega 6 fatty acids inhibits the
conversion of ALA into DHA and EPA. Being deficient in certain
vitamins and minerals also inhbits conversion of ALA into DHA and EPA.
Healthy bodies, contrary to popular belief, convert ALA into DHA and
EPA. Some researchers even believe that conversion in many people is
as inefficient as it is because the body will not convert more than is
needed…"
More than is needed .. ?
Is THAT the one of the .. keys .. ?
Too much of the OTHER fatty acids PREVENTS the **conversion** of Alpha-
linolenic.
Combine that with targeted destruction of Alpha-linolenic by refining
of our flours / removal of chaff and germ which contain the Alpha-
linolenic.
The refining and removal of alpha-linolenic acid from our vegetable
oils.
They take Alpha-linolenic out of our vegetable oils and call it ..
lecithin.
The INCLUSION of the oxidizing material iron in our flours.
THEN they tell you to make SURE you "watch out for it it may kill
ya" .. IE: soybean lecithin and allergy to soybean making the adding
of lecithin to virtually EVERY food .. "dangerous" ..
Putting the wrong oil in the beast.
BEE .. da .. plant.
Make SURE 'they' .. IE: doctors nurses nutritionists dieticians
alternative health gurus .. don>t let them convince you .. peas .. are
bad for you.
THEY are the ones' that are .. nuts.
Peas are high in alpha-linolenic acid as are all your green plant
foods are high in alpha-linolenic acid .
Peas are good for ya.
Write that down.
Just to be sure someone doesn>t convince you otherwise.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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Guest
|
| Posted: Thu Nov 27, 2008 9:49 pm Post subject: Re: Pufa Prevents Paranoia |
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| This is why fish oil is being tried for psycotic folk. |
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marcia
Guest
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| Posted: Thu Nov 27, 2008 11:15 pm Post subject: Re: Pufa Prevents Paranoia |
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|
On Nov 27, 12:09 am, ironjustice <ironjust...@cashette.com> wrote:
[quote]"With or without the omega-3 fatty acid alpha-linolenic acid"
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
[/quote]
Vegetarians should get their Omega-3 fatty acids from Flax seed oil.
Taking fish oil would break their dietary rules. |
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Guest
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| Posted: Thu Nov 27, 2008 11:54 pm Post subject: Re: Pufa Prevents Paranoia |
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It>s not about omega 3s, but about avoiding omega 6s. I avoid both,
and "cured" myself. No need to ingest highly oxidizable molecules.
The native Greenlanders did this and were lucky to live to reach their
40s. |
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ironjustice@aol.com
Guest
|
| Posted: Fri Nov 28, 2008 12:04 am Post subject: Re: Pufa Prevents Paranoia |
|
|
On Nov 27, 2:19 pm, anonym...@nowhere.you.know wrote:snip <<
You have been told not to post to my threads dioxin boy ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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ironjustice@aol.com
Guest
|
| Posted: Fri Nov 28, 2008 12:04 am Post subject: Re: Pufa Prevents Paranoia |
|
|
On Nov 27, 2:22 pm, anonym...@nowhere.you.know wrote:snip <<
You have been told not to post to my threads dioxin boy ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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ironjustice@aol.com
Guest
|
| Posted: Fri Nov 28, 2008 12:42 am Post subject: Re: Pufa Prevents Paranoia |
|
|
On Nov 27, 9:17 am, "ironjust...@aol.com" <ironjust...@aol.com>
wrote:alpha-linolenic acid <<
This somewhat explains the four times the rate of cigarette smoking in
schizophrenia.
"Substantiates 7 nicotinic acetylcholine receptor in schizophrenia"
http://www.fasebj.org/cgi/content/full/17/13/1948
The 7 nicotinic acetylcholine receptor in schizophrenia: decreased
mRNA levels in peripheral blood lymphocytes1
ORLY PERL*, TAL ILANI*, RAEL D. STROUS,, RAYA LAPIDUS and SARA FUCHS*,
2
* Department of Immunology, The Weizmann Institute of Science, Rehovot
76100, Israel; and
Beer Yaakov Mental Health Center and
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
2Correspondence: Department of Immunology, The Weizmann Institute of
Science, Rehovot 76100, Israel. E-mail: sara.fuchs@weizmann.ac.il
SPECIFIC AIMS
Schizophrenia is a neuropsychiatric disorder that affects about 1% of
the population worldwide. The precise pathophyisiology of
schizophrenia is still not known, though it is accepted that it
involves CNS alterations in neurotransmitters and their receptors. To
date, there are no reliable peripheral markers for schizophrenia and
its diagnosis relies mainly on descriptive behavioral and symptomatic
information. Thus, there is a need to develop convenient biological
assays for the identification, evaluation, and follow-up of
schizophrenia during treatment and to elucidate the molecular basis of
this disease. In our laboratory we are investigating human peripheral
blood lymphocytes (PBLs), as they have been found to express receptors
for several neurotransmitters and it has been suggested that such
peripheral receptors may reflect the respective brain receptors.
Recent studies indicate an association of the neuronal 7 nicotinic
acetylcholine receptor (7 AChR) with several aspects of schizophrenia,
and decreased levels of this receptor in postmortem brains of
schizophrenic patients have been reported. In view of that and in
search of peripheral markers for schizophrenia, our aim in the present
study was to find out whether there is a correlation between
schizophrenia and peripheral 7 AChR by analyzing the levels of 7 AChR
mRNA in PBLs. Such a correlation substantiates the involvement of 7
AChR in the pathophysiology of schizophrenia and proposes the assay of
7 AChR mRNA levels in PBLs as a potential peripheral biological marker
for this illness.
Published as doi: 10.1096/fj.03-0104fje.
(The FASEB Journal. 2003;17:1948-1950.)
© 2003 FASEB
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
[quote]On Nov 27, 8:29 am, "ironjust...@aol.com" <ironjust...@aol.com
wrote:"RISP Risperidone did not alter omega-3 fatty acid on the ALA-
diet."
http://www.modernforager.com
"Delta-5 desaturase is inhibited by EPA , meaning that the body works
to slow down EPA production when EPA is high. High levels of omega-6
in the diet can also affect the conversions.
Animal fat, transfat and excessive omega 6 fatty acids inhibits the
conversion of ALA into DHA and EPA. Being deficient in certain
vitamins and minerals also inhbits conversion of ALA into DHA and EPA.
Healthy bodies, contrary to popular belief, convert ALA into DHA and
EPA. Some researchers even believe that conversion in many people is
as inefficient as it is because the body will not convert more than is
needed…"
More than is needed .. ?
Is THAT the one of the .. keys .. ?
Too much of the OTHER fatty acids PREVENTS the **conversion** of Alpha-
linolenic.
Combine that with targeted destruction of Alpha-linolenic by refining
of our flours / removal of chaff and germ which contain the Alpha-
linolenic.
The refining and removal of alpha-linolenic acid from our vegetable
oils.
They take Alpha-linolenic out of our vegetable oils and call it ..
lecithin.
The INCLUSION of the oxidizing material iron in our flours.
THEN they tell you to make SURE you "watch out for it it may kill
ya" .. IE: soybean lecithin and allergy to soybean making the adding
of lecithin to virtually EVERY food .. "dangerous" ..
Putting the wrong oil in the beast.
BEE .. da .. plant.
Make SURE 'they' .. IE: doctors nurses nutritionists dieticians
alternative health gurus .. don>t let them convince you .. peas .. are
bad for you.
THEY are the ones' that are .. nuts.
Peas are high in alpha-linolenic acid as are all your green plant
foods are high in alpha-linolenic acid .
Peas are good for ya.
Write that down.
Just to be sure someone doesn>t convince you otherwise.
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk[/quote] |
|
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| Back to top |
ironjustice@aol.com
Guest
|
| Posted: Fri Nov 28, 2008 1:31 am Post subject: Re: Pufa Prevents Paranoia |
|
|
On Nov 27, 4:42 pm, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
This somewhat explains the four times the rate of cigarette smoking
in
schizophrenia. "Substantiates 7 nicotinic acetylcholine receptor in
schizophrenia" <<
Might make one wonder if those with ADHD or bi-polar or alzheimers
have a higher rate of smoking .. too .. ?
"¦Á7 nicotinic acetylcholine receptor (¦Á7 nAChR)"
This .. coincidentally .. is the same receptor being TARGETED in
alzheimers or lack thereof.
"Activation of ¦Á7 nAChR may provide a new therapeutic pathway"
"Reduced by nicotine treatment"
"Inhibition of a7 nAChR in the cells exposed to high ferrous iron"
AJRCMB Articles in Press.
Published on April 12, 2007 as doi:10.1165/rcmb.2006-0240OC
ABSTRACT
New evidence indicates that neural mechanisms can downregulate
acute inflammation.
In these studies, we tested the potential role of the ¦Á7 nicotinic
acetylcholine receptor (¦Á7 nAChR) in a rodent model of
acid-induced acute lung injury.
We first determined that the ¦Á7 nAChR was expressed by
alveolar macrophages and lung epithelial cells.
Then, using an acid-induced acute lung injury mouse model,
we found that nicotine, choline, and PNU-282987
(a specific ¦Á7 nAChR agonist) decreased excess lung water
and lung vascular permeability, and reduced protein
concentration in the bronchoalveolar lavage(BAL).
Deficiency of ¦Á7 nAChR resulted in a 2-fold increase in
excess lung water and lung vascular permeability.
The reduction of proinflammatory cytokines (MIP-2 and
TNF-¦Á) in the BAL with nicotine probably resulted from
the suppression of NF-¦ÊB activation in alveolar macrophages.
The beneficial effect of nicotine was also tested in
rat model of acid-induced acute lung injury in which BAL
protein and RAGE, a marker of type I cell injury, were
reduced by nicotine treatment.
These results indicate that activation of ¦Á7 nAChR may
provide a new therapeutic pathway for the treatment of
acute lung injury.
---------------
Oxidative stress might be a mechanism connected with the
decreased ¦Á7 nicotinic receptor influenced by high-concentration
of fluoride in SH-SY5Y neuroblastoma cells
QIN GAO ; LIU Yan-Jie ; GUAN Zhi-Zhong ;
Abstract
The possible mechanism concerning decreased ¦Á7
nicotinic acetylcholine receptor (nAChR) influenced
by fluorosis was investigated.
SH-SY5Y cells were exposed to fluoride within the
range of 0.05-5 ¦ÌM, or ferrous iron (1-100 pM), a free
radical inducer.
The levels of ¦Á7 nAChR expression, lipid peroxidation
and protein oxidation were detected.
The results showed that both high-concentrations of fluoride
and ferrous iron induced increased levels of lipid peroxidation
and protein oxidation in SH-SY5Y cells with
concentration-dependent manners.
In addition, inhibition of a7 nAChR at protein level was observed
in the cells exposed to high amounts of fluoride or ferrous iron.
Furthermore, a declined value of Bmax in [125I]¦Á-bungarotoxin
binding sites was found in the cells treated with the
high-concentration of fluoride.
Interestingly, antioxidants (vitamin E and glutathione) can attenuate
the inhibition of the receptor induced by fluoride.
These findings suggest that oxidative stress resulted from fluorosis
might directly induce the deficit of a7 nAChR.
Revue / Journal Title
Toxicology in vitro ISSN 0887-2333 CODEN TIVIEQ
Source / Source
2008, vol. 22, no4, pp. 837-843 [7 page(s) (article)]
Langue / Language
Anglais
Editeur / Publisher
Elsevier Science, Oxford, ROYAUME-UNI (1987) (Revue)
Mots-cl¨¦s d>auteur / Author Keywords
Fluoride ; Ferrous iron ; ¦Á7 Nicotinic receptor ; Oxidative stress ;
SH-SY5Y cells ;
Localisation / Location
INIST-CNRS, Cote INIST : 21203, 35400017375834.0020
-----------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
[quote]
http://www.fasebj.org/cgi/content/full/17/13/1948
The7nicotinicacetylcholinereceptorin schizophrenia: decreased
mRNA levels in peripheral blood lymphocytes1
ORLY PERL*, TAL ILANI*, RAEL D. STROUS,, RAYA LAPIDUS and SARA FUCHS*,
2
* Department of Immunology, The Weizmann Institute of Science, Rehovot
76100, Israel; and
Beer Yaakov Mental Health Center and
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
2Correspondence: Department of Immunology, The Weizmann Institute of
Science, Rehovot 76100, Israel. E-mail: sara.fu...@weizmann.ac.il
SPECIFIC AIMS
Schizophrenia is a neuropsychiatric disorder that affects about 1% of
the population worldwide. The precise pathophyisiology of
schizophrenia is still not known, though it is accepted that it
involves CNS alterations in neurotransmitters and their receptors. To
date, there are no reliable peripheral markers for schizophrenia and
its diagnosis relies mainly on descriptive behavioral and symptomatic
information. Thus, there is a need to develop convenient biological
assays for the identification, evaluation, and follow-up of
schizophrenia during treatment and to elucidate the molecular basis of
this disease. In our laboratory we are investigating human peripheral
blood lymphocytes (PBLs), as they have been found to express receptors
for several neurotransmitters and it has been suggested that such
peripheral receptors may reflect the respective brain receptors.
Recent studies indicate an association of the neuronal7nicotinicacetylcholinereceptor(7AChR) with several aspects of schizophrenia,
and decreased levels of thisreceptorin postmortem brains of
schizophrenic patients have been reported. In view of that and in
search of peripheral markers for schizophrenia, our aim in the present
study was to find out whether there is a correlation between
schizophrenia and peripheral7AChR by analyzing the levels of7AChR
mRNA in PBLs. Such a correlation substantiates the involvement of7
AChR in the pathophysiology of schizophrenia and proposes the assay of7AChR mRNA levels in PBLs as a potential peripheral biological marker
for this illness.
Published as doi: 10.1096/fj.03-0104fje.
(The FASEB Journal. 2003;17:1948-1950.)
(c) 2003 FASEB
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
On Nov 27, 8:29 am, "ironjust...@aol.com" <ironjust...@aol.com
wrote:"RISP Risperidone did not alter omega-3 fatty acid on the ALA-
diet."
http://www.modernforager.com
"Delta-5 desaturase is inhibited by EPA , meaning that the body works
to slow down EPA production when EPA is high. High levels of omega-6
in the diet can also affect the conversions.
Animal fat, transfat and excessive omega 6 fatty acids inhibits the
conversion of ALA into DHA and EPA. Being deficient in certain
vitamins and minerals also inhbits conversion of ALA into DHA and EPA.
Healthy bodies, contrary to popular belief, convert ALA into DHA and
EPA. Some researchers even believe that conversion in many people is
as inefficient as it is because the body will not convert more than is
needed..."
More than is needed .. ?
Is THAT the one of the .. keys .. ?
Too much of the OTHER fatty acids PREVENTS the **conversion** of Alpha-
linolenic.
Combine that with targeted destruction of Alpha-linolenic by refining
of our flours / removal of chaff and germ which contain the Alpha-
linolenic.
The refining and removal of alpha-linolenic acid from our vegetable
oils.
They take Alpha-linolenic out of our vegetable oils and call it ..
lecithin.
The INCLUSION of the oxidizing material iron in our flours.
THEN they tell you to make SURE you "watch out for it it may kill
ya" .. IE: soybean lecithin and allergy to soybean making the adding
of lecithin to virtually EVERY food .. "dangerous" ..
Putting the wrong oil in the beast.
BEE .. da .. plant.
Make SURE 'they' .. IE: doctors nurses nutritionists dieticians
alternative health gurus .. don>t let them convince you .. peas .. are
bad for you.
THEY are the ones' that are .. nuts.
Peas are high in alpha-linolenic acid as are all your green plant
foods are high in alpha-linolenic acid .
Peas are good for ya.
Write that down.
Just to be sure someone doesn>t convince you otherwise.
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk- Hide quoted text -
- Show quoted text -[/quote] |
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ironjustice@aol.com
Guest
|
| Posted: Fri Nov 28, 2008 1:37 am Post subject: Re: Pufa Prevents Paranoia |
|
|
On Nov 27, 5:26 pm, m...@otr.com wrote:
More not less receptors should be associated with increased smoking.
<<
They smoke four times more .. pal ..
They don>t smoke four times more .. ?
They will BEG you for a smoke .. it is that .. bad ..
Now .. what were you saying about your .. opinion as to the efficacy
of nicotine in schizophrenia .. ?
Evidence based medicine .. IE: decreased receptors in the brain AND
the FACT they smoke four times more than everyone else MEANS .. we
have what is called a PARADOX .. ?
Ok ..
I>ll settle for that ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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