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 Posted: Fri Jul 25, 2008 9:32 pm Post subject: Protective effect of persimmon (Diospyros kaki) peel proanth |
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1: Biol Pharm Bull. 2008 Jun;31(6):1265-9. Links
Protective effect of persimmon (Diospyros kaki) peel proanthocyanidin
against oxidative damage under H2O2-induced cellular senescence.Lee
YA, Cho EJ, Yokozawa T.
Institute of Natural Medicine, University of Toyama, Sugitani, Toyama,
Japan.
8-Hydroxy-2'-deoxyguanosine (8-OHdG), one of the most abundant
oxidative DNA adducts, is used as an indicator of oxidative DNA damage
associated with aging. Among homologs of the silent information
regulator (Sir), sirtuin 1 (SIRT1) is suggested as a regulator of the
apoptotic response to DNA damage. Since it has been suggested that the
aging process can be delayed by the attenuation of oxidative damage
such as DNA damage or SIRT1 modulation, we focused on the protective
effect against cellular oxidative damage of persimmon peel, a
proanthocyanidin-rich food, in relation to its level of
polymerization. We confirmed that 8-OHdG expression in TIG-1 human
fibroblasts was increased by treatment with 300 microM H2O2 for 2 h.
On the other hand, the nuclear SIRT1 level was decreased in H2O2-
treated as compared with non-pretreated cells. However, pretreatments
with polymers and oligomers led to a decrease in 8-OHdG and elevation
in nuclear SIRT1 expression in a concentration-dependent manner. In
particular, oligomers exerted a stronger effect. The present study
supports the protective potential of proanthocyanidin from persimmon
peel against oxidative damage under the aging process, and suggests
that the polymerization of proanthocyanidin plays an important role in
retarding aging in a cellular senescence model.
PMID: 18520066 [PubMed - indexed for MEDLINE] |
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