ironjustice
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 Posted: Wed Nov 26, 2008 3:10 pm Post subject: Migraine Brain Iron Accumulation |
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"Iron concentration/accumulation and migraine pathophysiology."
Iron accumulation in deep brain nuclei in migraine: a population-based
magnetic resonance imaging study.
Kruit MC, Launer LJ, Overbosch J, van Buchem MA, Ferrari MD
Cephalalgia 2008 Nov 19.
A small magnetic resonance imaging (MRI) study showed increased iron
depositions in the periaqueductal grey matter in migraineurs,
suggestive of a disturbed central antinociceptive neuronal network.
With 1.5-T MRI, we assessed iron concentrations in seven deep brain
nuclei in a large population-based cohort.
We compared T2 values between migraineurs (n = 138) and controls (n =
75), with multivariate regression analysis.
Analyses were conducted in age strata (< 50, n = 112; >/= 50) because
iron measures are increasingly influenced by non-iron-related factors
in the older group. Overall, migraineurs and controls did not differ,
nor did migraineurs with vs. without aura.
In the younger migraineurs compared with controls, T2 values were
lower in the putamen (P = 0.02), globus pallidus (P = 0.03) and red
nucleus (P = 0.03). Similarly, in these younger migraineurs,
controlling for age, those with longer migraine history had lower T2
values in the putamen (P = 0.01), caudate (P = 0.04) and red nucleus
(P = 0.001).
Repeated migraine attacks are associated with increased iron
concentration/accumulation in multiple deep nuclei that are involved
in central pain processing and migraine pathophysiology.
It remains unclear whether iron accumulation in the antinociceptive
network has a causative role in the development of (chronic) migraine
headache.
Cephalalgia : 2008. London.
ISSN 0333-1024
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