Science and Technology news... :: View topic - Effects of Acetyl-L-Carnitine on lipofuscin content in 3 bra

Guest

The reduction was most significant in the hippocampus reducing LF
content by almost half in aged mice.

http://www.journalarchive.jst.go.jp/jnlpdf.php?cdjournal=jphs1951&cdvol=48&noissue=3&startpage=365&lang=en&from=jnlabstract

Guest

Arch Gerontol Geriatr. 1989 Sep-Oct;9(2):147-53. Links
Reduced lipofuscin accumulation in senescent rat brain by long-term
acetyl-L-carnitine treatment.Amenta F, Ferrante F, Lucreziotti R,
Ricci A, Ramacci MT.
Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome,
Italy.

By using fluorescence microscopy and microfluorimetric techniques, the
effects of ageing and of 11 months acetyl-L-carnitine (ALCAR)
treatment on lipofuscin deposition within the cytoplasm of pyramidal
neurons of rat prefrontal cortex and hippocampus (CA3 field) were
assessed. No lipofuscin autofluorescence was observed in the nerve
cell bodies of neurons under study in young rats (3 months of age),
but lipopigment had accumulated in the same nerve cells of senescent
rats (22 months of age). ALCAR administration significantly reduced
the accumulation of lipofuscin within pyramidal neurons of the brain
areas examined.

PMID: 2589915 [PubMed - indexed for MEDLINE]

Ted · Guest

On Oct 2, 4:55 pm, timoth...@my-deja.com wrote:
[quote]Arch Gerontol Geriatr. 1989 Sep-Oct;9(2):147-53. Links
Reduced lipofuscin accumulation in senescent rat brain by long-term
acetyl-L-carnitine treatment.Amenta F, Ferrante F, Lucreziotti R,
Ricci A, Ramacci MT.
Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome,
Italy.

By using fluorescence microscopy and microfluorimetric techniques, the
effects of ageing and of 11 months acetyl-L-carnitine (ALCAR)
treatment on lipofuscin deposition within the cytoplasm of pyramidal
neurons of rat prefrontal cortex and hippocampus (CA3 field) were
assessed. No lipofuscin autofluorescence was observed in the nerve
cell bodies of neurons under study in young rats (3 months of age),
but lipopigment had accumulated in the same nerve cells of senescent
rats (22 months of age). ALCAR administration significantly reduced
the accumulation of lipofuscin within pyramidal neurons of the brain
areas examined.

PMID: 2589915 [PubMed - indexed for MEDLINE]
[/quote]
So if I understand this correctly not only does ALC reduce the
production of lipofuscin, but it also clears out deposits that have
already been formed. I have recently begun taking it. I am taking 1
gram in the morning. Is that a reasonable dose?

jw · Guest

On Oct 2, 5:47 pm, Ted <chuckfras...@gmail.com> wrote:
[quote]On Oct 2, 4:55 pm, timoth...@my-deja.com wrote:

Arch Gerontol Geriatr. 1989 Sep-Oct;9(2):147-53. Links
Reduced lipofuscin accumulation in senescent rat brain by long-term
acetyl-L-carnitine treatment.Amenta F, Ferrante F, Lucreziotti R,
Ricci A, Ramacci MT.
Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome,
Italy.

By using fluorescence microscopy and microfluorimetric techniques, the
effects of ageing and of 11 months acetyl-L-carnitine (ALCAR)
treatment on lipofuscin deposition within the cytoplasm of pyramidal
neurons of rat prefrontal cortex and hippocampus (CA3 field) were
assessed. No lipofuscin autofluorescence was observed in the nerve
cell bodies of neurons under study in young rats (3 months of age),
but lipopigment had accumulated in the same nerve cells of senescent
rats (22 months of age). ALCAR administration significantly reduced
the accumulation of lipofuscin within pyramidal neurons of the brain
areas examined.

PMID: 2589915 [PubMed - indexed for MEDLINE]

So if I understand this correctly not only does ALC reduce the
production of lipofuscin, but it also clears out deposits that have
already been formed. I have recently begun taking it. I am taking 1
gram in the morning. Is that a reasonable dose?
[/quote]
yes, and take R-lipoic acid as well to keep down mitochondrial ROS
production which would undesirably increase on ALCAR alone.

Ted · Guest

On Oct 2, 11:50 pm, jw <jwesl...@gmail.com> wrote:
[quote]On Oct 2, 5:47 pm, Ted <chuckfras...@gmail.com> wrote:

On Oct 2, 4:55 pm, timoth...@my-deja.com wrote:

Arch Gerontol Geriatr. 1989 Sep-Oct;9(2):147-53. Links
Reduced lipofuscin accumulation in senescent rat brain by long-term
acetyl-L-carnitine treatment.Amenta F, Ferrante F, Lucreziotti R,
Ricci A, Ramacci MT.
Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome,
Italy.

By using fluorescence microscopy and microfluorimetric techniques, the
effects of ageing and of 11 months acetyl-L-carnitine (ALCAR)
treatment on lipofuscin deposition within the cytoplasm of pyramidal
neurons of rat prefrontal cortex and hippocampus (CA3 field) were
assessed. No lipofuscin autofluorescence was observed in the nerve
cell bodies of neurons under study in young rats (3 months of age),
but lipopigment had accumulated in the same nerve cells of senescent
rats (22 months of age). ALCAR administration significantly reduced
the accumulation of lipofuscin within pyramidal neurons of the brain
areas examined.

PMID: 2589915 [PubMed - indexed for MEDLINE]

So if I understand this correctly not only does ALC reduce the
production of lipofuscin, but it also clears out deposits that have
already been formed. I have recently begun taking it. I am taking 1
gram in the morning. Is that a reasonable dose?

yes, and take R-lipoic acid as well to keep down mitochondrial ROS
production which would undesirably increase on ALCAR alone.
[/quote]
Thanks for your response. I have been taking two of these.
http://www.easycart.net/BeyondACenturyInc./images/5085.jpg
So I get 1G of ALC and 400mg of lipoic acid. And 10mg of bioperine,
although I am not so sure that helps. I have heard that it is
ineffective orally. I also noticed that it just says alpha lipoic acid
on the label. It doesn>t specify the R form. I am thinking that maybe
I should just buy the powder and mix it.

John Hasenkam · Guest

"jw" <jwesleyb@gmail.com> wrote in message
news:c8b7ab5e-8695-4431-8c92-6e3525537aef@l42g2000hsc.googlegroups.com...
On Oct 2, 5:47 pm, Ted <chuckfras...@gmail.com> wrote:
[quote]On Oct 2, 4:55 pm, timoth...@my-deja.com wrote:

Arch Gerontol Geriatr. 1989 Sep-Oct;9(2):147-53. Links
Reduced lipofuscin accumulation in senescent rat brain by long-term
acetyl-L-carnitine treatment.Amenta F, Ferrante F, Lucreziotti R,
Ricci A, Ramacci MT.
Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome,
Italy.

By using fluorescence microscopy and microfluorimetric techniques, the
effects of ageing and of 11 months acetyl-L-carnitine (ALCAR)
treatment on lipofuscin deposition within the cytoplasm of pyramidal
neurons of rat prefrontal cortex and hippocampus (CA3 field) were
assessed. No lipofuscin autofluorescence was observed in the nerve
cell bodies of neurons under study in young rats (3 months of age),
but lipopigment had accumulated in the same nerve cells of senescent
rats (22 months of age). ALCAR administration significantly reduced
the accumulation of lipofuscin within pyramidal neurons of the brain
areas examined.

PMID: 2589915 [PubMed - indexed for MEDLINE]

So if I understand this correctly not only does ALC reduce the
production of lipofuscin, but it also clears out deposits that have
already been formed. I have recently begun taking it. I am taking 1
gram in the morning. Is that a reasonable dose?
[/quote]
yes, and take R-lipoic acid as well to keep down mitochondrial ROS
production which would undesirably increase on ALCAR alone.

Good point jw, ALA should be added to the mix. In phototrop, a compound used
to treat AMD, and with some promising clinical results for early AMD, they
did witness regression of drusen. However in phototrop they did not include
ALA, a mistake in my view.

Lipofuscin is an important component of aging that is overlooked. In the
study originally cited the effective dosage was a whooping 100mg\kg\day!
50mg had little effect.

http://healthycuriousity.blogspot.com/2008/10/lipofuscin-and-aging.html

trigonometry1972@gmail.co · Guest

On Oct 3, 8:24 pm, "John Hasenkam" <jo...@goawayplease.com> wrote:
[quote]"jw" <jwesl...@gmail.com> wrote in message

news:c8b7ab5e-8695-4431-8c92-6e3525537aef@l42g2000hsc.googlegroups.com...
On Oct 2, 5:47 pm, Ted <chuckfras...@gmail.com> wrote:

On Oct 2, 4:55 pm, timoth...@my-deja.com wrote:

Arch Gerontol Geriatr. 1989 Sep-Oct;9(2):147-53. Links
Reduced lipofuscin accumulation in senescent rat brain by long-term
acetyl-L-carnitine treatment.Amenta F, Ferrante F, Lucreziotti R,
Ricci A, Ramacci MT.
Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome,
Italy.

By using fluorescence microscopy and microfluorimetric techniques, the
effects of ageing and of 11 months acetyl-L-carnitine (ALCAR)
treatment on lipofuscin deposition within the cytoplasm of pyramidal
neurons of rat prefrontal cortex and hippocampus (CA3 field) were
assessed. No lipofuscin autofluorescence was observed in the nerve
cell bodies of neurons under study in young rats (3 months of age),
but lipopigment had accumulated in the same nerve cells of senescent
rats (22 months of age). ALCAR administration significantly reduced
the accumulation of lipofuscin within pyramidal neurons of the brain
areas examined.

PMID: 2589915 [PubMed - indexed for MEDLINE]

So if I understand this correctly not only does ALC reduce the
production of lipofuscin, but it also clears out deposits that have
already been formed. I have recently begun taking it. I am taking 1
gram in the morning. Is that a reasonable dose?

yes, and take R-lipoic acid as well to keep down mitochondrial ROS
production which would undesirably increase on ALCAR alone.

Good point jw, ALA should be added to the mix. In phototrop, a compound used
to treat AMD, and with some promising clinical results for early AMD, they
did witness regression of drusen. However in phototrop they did not include
ALA, a mistake in my view.

Lipofuscin is an important component of aging that is overlooked. In the
study originally cited the effective dosage was a whooping 100mg\kg\day!
50mg had little effect.

[/quote]
The work was done mice or rats wasn>t it. If so one has to allow
for their higher metabolic rate of the test subjects
and reduce the human dose accordingly.
Which likely puts the dose around a gram and half as an off hand
guess. Doable but expensive with r alpha lipoic acid.

jw · Guest

On Oct 6, 5:37 am, "trigonometry1...@gmail.com |"
<trigonometry1...@gmail.com> wrote:
[quote]On Oct 3, 8:24 pm, "John Hasenkam" <jo...@goawayplease.com> wrote:

"jw" <jwesl...@gmail.com> wrote in message

news:c8b7ab5e-8695-4431-8c92-6e3525537aef@l42g2000hsc.googlegroups.com....
On Oct 2, 5:47 pm, Ted <chuckfras...@gmail.com> wrote:

On Oct 2, 4:55 pm, timoth...@my-deja.com wrote:

Arch Gerontol Geriatr. 1989 Sep-Oct;9(2):147-53. Links
Reduced lipofuscin accumulation in senescent rat brain by long-term
acetyl-L-carnitine treatment.Amenta F, Ferrante F, Lucreziotti R,
Ricci A, Ramacci MT.
Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome,
Italy.

By using fluorescence microscopy and microfluorimetric techniques, the
effects of ageing and of 11 months acetyl-L-carnitine (ALCAR)
treatment on lipofuscin deposition within the cytoplasm of pyramidal
neurons of rat prefrontal cortex and hippocampus (CA3 field) were
assessed. No lipofuscin autofluorescence was observed in the nerve
cell bodies of neurons under study in young rats (3 months of age),
but lipopigment had accumulated in the same nerve cells of senescent
rats (22 months of age). ALCAR administration significantly reduced
the accumulation of lipofuscin within pyramidal neurons of the brain
areas examined.

PMID: 2589915 [PubMed - indexed for MEDLINE]

So if I understand this correctly not only does ALC reduce the
production of lipofuscin, but it also clears out deposits that have
already been formed. I have recently begun taking it. I am taking 1
gram in the morning. Is that a reasonable dose?

yes, and take R-lipoic acid as well to keep down mitochondrial ROS
production which would undesirably increase on ALCAR alone.

Good point jw, ALA should be added to the mix. In phototrop, a compound used
to treat AMD, and with some promising clinical results for early AMD, they
did witness regression of drusen. However in phototrop they did not include
ALA, a mistake in my view.

Lipofuscin is an important component of aging that is overlooked. In the
study originally cited the effective dosage was a whooping 100mg\kg\day!
50mg had little effect.

The work was done mice or rats wasn>t it. If so one has to allow
for their higher metabolic rate of the test subjects
and reduce the human dose accordingly.
Which likely puts the dose around a gram and half as an off hand
guess. Doable but expensive with r alpha lipoic acid.
[/quote]
the 50 and 100 mg/kg/day dose was in rats was ALCAR , not lipoic acid.

Ted · Guest

On Oct 6, 8:34 pm, jw <jwesl...@gmail.com> wrote:
[quote]On Oct 6, 5:37 am, "trigonometry1...@gmail.com |"

trigonometry1...@gmail.com> wrote:
On Oct 3, 8:24 pm, "John Hasenkam" <jo...@goawayplease.com> wrote:

"jw" <jwesl...@gmail.com> wrote in message

news:c8b7ab5e-8695-4431-8c92-6e3525537aef@l42g2000hsc.googlegroups.com....
On Oct 2, 5:47 pm, Ted <chuckfras...@gmail.com> wrote:

On Oct 2, 4:55 pm, timoth...@my-deja.com wrote:

Arch Gerontol Geriatr. 1989 Sep-Oct;9(2):147-53. Links
Reduced lipofuscin accumulation in senescent rat brain by long-term
acetyl-L-carnitine treatment.Amenta F, Ferrante F, Lucreziotti R,
Ricci A, Ramacci MT.
Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome,
Italy.

By using fluorescence microscopy and microfluorimetric techniques, the
effects of ageing and of 11 months acetyl-L-carnitine (ALCAR)
treatment on lipofuscin deposition within the cytoplasm of pyramidal
neurons of rat prefrontal cortex and hippocampus (CA3 field) were
assessed. No lipofuscin autofluorescence was observed in the nerve
cell bodies of neurons under study in young rats (3 months of age),
but lipopigment had accumulated in the same nerve cells of senescent
rats (22 months of age). ALCAR administration significantly reduced
the accumulation of lipofuscin within pyramidal neurons of the brain
areas examined.

PMID: 2589915 [PubMed - indexed for MEDLINE]

So if I understand this correctly not only does ALC reduce the
production of lipofuscin, but it also clears out deposits that have
already been formed. I have recently begun taking it. I am taking 1
gram in the morning. Is that a reasonable dose?

yes, and take R-lipoic acid as well to keep down mitochondrial ROS
production which would undesirably increase on ALCAR alone.

Good point jw, ALA should be added to the mix. In phototrop, a compound used
to treat AMD, and with some promising clinical results for early AMD, they
did witness regression of drusen. However in phototrop they did not include
ALA, a mistake in my view.

Lipofuscin is an important component of aging that is overlooked. In the
study originally cited the effective dosage was a whooping 100mg\kg\day!
50mg had little effect.

The work was done mice or rats wasn>t it. If so one has to allow
for their higher metabolic rate of the test subjects
and reduce the human dose accordingly.
Which likely puts the dose around a gram and half as an off hand
guess. Doable but expensive with r alpha lipoic acid.

the 50 and 100 mg/kg/day dose was in rats was ALCAR , not lipoic acid.
[/quote]
Beyond a century has a 50/50 alpha lipoic acid. Is that okay or is
there a source containing just the r form?

Guest

On Oct 7, 7:29 pm, Ted <chuckfras...@gmail.com> wrote:
[quote]On Oct 6, 8:34 pm, jw <jwesl...@gmail.com> wrote:

On Oct 6, 5:37 am, "trigonometry1...@gmail.com |"

trigonometry1...@gmail.com> wrote:
On Oct 3, 8:24 pm, "John Hasenkam" <jo...@goawayplease.com> wrote:

"jw" <jwesl...@gmail.com> wrote in message

news:c8b7ab5e-8695-4431-8c92-6e3525537aef@l42g2000hsc.googlegroups.com...
On Oct 2, 5:47 pm, Ted <chuckfras...@gmail.com> wrote:

On Oct 2, 4:55 pm, timoth...@my-deja.com wrote:

Arch Gerontol Geriatr. 1989 Sep-Oct;9(2):147-53. Links
Reduced lipofuscin accumulation in senescent rat brain by long-term
acetyl-L-carnitine treatment.Amenta F, Ferrante F, Lucreziotti R,
Ricci A, Ramacci MT.
Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome,
Italy.

By using fluorescence microscopy and microfluorimetric techniques, the
effects of ageing and of 11 months acetyl-L-carnitine (ALCAR)
treatment on lipofuscin deposition within the cytoplasm of pyramidal
neurons of rat prefrontal cortex and hippocampus (CA3 field) were
assessed. No lipofuscin autofluorescence was observed in the nerve
cell bodies of neurons under study in young rats (3 months of age),
but lipopigment had accumulated in the same nerve cells of senescent
rats (22 months of age). ALCAR administration significantly reduced
the accumulation of lipofuscin within pyramidal neurons of the brain
areas examined.

PMID: 2589915 [PubMed - indexed for MEDLINE]

So if I understand this correctly not only does ALC reduce the
production of lipofuscin, but it also clears out deposits that have
already been formed. I have recently begun taking it. I am taking 1
gram in the morning. Is that a reasonable dose?

yes, and take R-lipoic acid as well to keep down mitochondrial ROS
production which would undesirably increase on ALCAR alone.

Good point jw, ALA should be added to the mix. In phototrop, a compound used
to treat AMD, and with some promising clinical results for early AMD, they
did witness regression of drusen. However in phototrop they did not include
ALA, a mistake in my view.

Lipofuscin is an important component of aging that is overlooked. In the
study originally cited the effective dosage was a whooping 100mg\kg\day!
50mg had little effect.

The work was done mice or rats wasn>t it. If so one has to allow
for their higher metabolic rate of the test subjects
and reduce the human dose accordingly.
Which likely puts the dose around a gram and half as an off hand
guess. Doable but expensive with r alpha lipoic acid.

the 50 and 100 mg/kg/day dose was in rats was ALCAR , not lipoic acid.

Beyond a century has a 50/50 alpha lipoic acid. Is that okay or is
there a source containing just the r form?
[/quote]
There are several sources of the R form, including Gronova and
Doctor>s Best. Also not you need extra boitin if you supplement with
lipoic acid.Some supplements include it, others do not.

Ted · Guest

On Oct 8, 4:38 pm, r...@my-deja.com wrote:
[quote]On Oct 7, 7:29 pm, Ted <chuckfras...@gmail.com> wrote:

On Oct 6, 8:34 pm, jw <jwesl...@gmail.com> wrote:

On Oct 6, 5:37 am, "trigonometry1...@gmail.com |"

trigonometry1...@gmail.com> wrote:
On Oct 3, 8:24 pm, "John Hasenkam" <jo...@goawayplease.com> wrote:

"jw" <jwesl...@gmail.com> wrote in message

news:c8b7ab5e-8695-4431-8c92-6e3525537aef@l42g2000hsc.googlegroups..com...
On Oct 2, 5:47 pm, Ted <chuckfras...@gmail.com> wrote:

On Oct 2, 4:55 pm, timoth...@my-deja.com wrote:

Arch Gerontol Geriatr. 1989 Sep-Oct;9(2):147-53. Links
Reduced lipofuscin accumulation in senescent rat brain by long-term
acetyl-L-carnitine treatment.Amenta F, Ferrante F, Lucreziotti R,
Ricci A, Ramacci MT.
Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome,
Italy.

By using fluorescence microscopy and microfluorimetric techniques, the
effects of ageing and of 11 months acetyl-L-carnitine (ALCAR)
treatment on lipofuscin deposition within the cytoplasm of pyramidal
neurons of rat prefrontal cortex and hippocampus (CA3 field) were
assessed. No lipofuscin autofluorescence was observed in the nerve
cell bodies of neurons under study in young rats (3 months of age),
but lipopigment had accumulated in the same nerve cells of senescent
rats (22 months of age). ALCAR administration significantly reduced
the accumulation of lipofuscin within pyramidal neurons of the brain
areas examined.

PMID: 2589915 [PubMed - indexed for MEDLINE]

So if I understand this correctly not only does ALC reduce the
production of lipofuscin, but it also clears out deposits that have
already been formed. I have recently begun taking it. I am taking 1
gram in the morning. Is that a reasonable dose?

yes, and take R-lipoic acid as well to keep down mitochondrial ROS
production which would undesirably increase on ALCAR alone.

Good point jw, ALA should be added to the mix. In phototrop, a compound used
to treat AMD, and with some promising clinical results for early AMD, they
did witness regression of drusen. However in phototrop they did not include
ALA, a mistake in my view.

Lipofuscin is an important component of aging that is overlooked. In the
study originally cited the effective dosage was a whooping 100mg\kg\day!
50mg had little effect.

The work was done mice or rats wasn>t it. If so one has to allow
for their higher metabolic rate of the test subjects
and reduce the human dose accordingly.
Which likely puts the dose around a gram and half as an off hand
guess. Doable but expensive with r alpha lipoic acid.

the 50 and 100 mg/kg/day dose was in rats was ALCAR , not lipoic acid..

Beyond a century has a 50/50 alpha lipoic acid. Is that okay or is
there a source containing just the r form?

There are several sources of the R form, including Gronova and
Doctor>s Best. Also not you need extra boitin if you supplement with
lipoic acid.Some supplements include it, others do not.
[/quote]
Thanks for the advice. I appreciate that.

Ted · Guest

On Oct 8, 4:38 pm, r...@my-deja.com wrote:
[quote]On Oct 7, 7:29 pm, Ted <chuckfras...@gmail.com> wrote:

On Oct 6, 8:34 pm, jw <jwesl...@gmail.com> wrote:

On Oct 6, 5:37 am, "trigonometry1...@gmail.com |"

trigonometry1...@gmail.com> wrote:
On Oct 3, 8:24 pm, "John Hasenkam" <jo...@goawayplease.com> wrote:

"jw" <jwesl...@gmail.com> wrote in message

news:c8b7ab5e-8695-4431-8c92-6e3525537aef@l42g2000hsc.googlegroups..com...
On Oct 2, 5:47 pm, Ted <chuckfras...@gmail.com> wrote:

On Oct 2, 4:55 pm, timoth...@my-deja.com wrote:

Arch Gerontol Geriatr. 1989 Sep-Oct;9(2):147-53. Links
Reduced lipofuscin accumulation in senescent rat brain by long-term
acetyl-L-carnitine treatment.Amenta F, Ferrante F, Lucreziotti R,
Ricci A, Ramacci MT.
Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome,
Italy.

By using fluorescence microscopy and microfluorimetric techniques, the
effects of ageing and of 11 months acetyl-L-carnitine (ALCAR)
treatment on lipofuscin deposition within the cytoplasm of pyramidal
neurons of rat prefrontal cortex and hippocampus (CA3 field) were
assessed. No lipofuscin autofluorescence was observed in the nerve
cell bodies of neurons under study in young rats (3 months of age),
but lipopigment had accumulated in the same nerve cells of senescent
rats (22 months of age). ALCAR administration significantly reduced
the accumulation of lipofuscin within pyramidal neurons of the brain
areas examined.

PMID: 2589915 [PubMed - indexed for MEDLINE]

So if I understand this correctly not only does ALC reduce the
production of lipofuscin, but it also clears out deposits that have
already been formed. I have recently begun taking it. I am taking 1
gram in the morning. Is that a reasonable dose?

yes, and take R-lipoic acid as well to keep down mitochondrial ROS
production which would undesirably increase on ALCAR alone.

Good point jw, ALA should be added to the mix. In phototrop, a compound used
to treat AMD, and with some promising clinical results for early AMD, they
did witness regression of drusen. However in phototrop they did not include
ALA, a mistake in my view.

Lipofuscin is an important component of aging that is overlooked. In the
study originally cited the effective dosage was a whooping 100mg\kg\day!
50mg had little effect.

The work was done mice or rats wasn>t it. If so one has to allow
for their higher metabolic rate of the test subjects
and reduce the human dose accordingly.
Which likely puts the dose around a gram and half as an off hand
guess. Doable but expensive with r alpha lipoic acid.

the 50 and 100 mg/kg/day dose was in rats was ALCAR , not lipoic acid..

Beyond a century has a 50/50 alpha lipoic acid. Is that okay or is
there a source containing just the r form?

There are several sources of the R form, including Gronova and
Doctor>s Best. Also not you need extra boitin if you supplement with
lipoic acid.Some supplements include it, others do not.
[/quote]
Is there any benefit in taking a mixture of both forms? Or is it only
a good idea to take the R form?

jw · Guest

On Oct 9, 1:58 pm, Ted <chuckfras...@gmail.com> wrote:
[quote]On Oct 8, 4:38 pm, r...@my-deja.com wrote:

On Oct 7, 7:29 pm, Ted <chuckfras...@gmail.com> wrote:

On Oct 6, 8:34 pm, jw <jwesl...@gmail.com> wrote:

On Oct 6, 5:37 am, "trigonometry1...@gmail.com |"

trigonometry1...@gmail.com> wrote:
On Oct 3, 8:24 pm, "John Hasenkam" <jo...@goawayplease.com> wrote:

"jw" <jwesl...@gmail.com> wrote in message

news:c8b7ab5e-8695-4431-8c92-6e3525537aef@l42g2000hsc.googlegroups.com...
On Oct 2, 5:47 pm, Ted <chuckfras...@gmail.com> wrote:

On Oct 2, 4:55 pm, timoth...@my-deja.com wrote:

Arch Gerontol Geriatr. 1989 Sep-Oct;9(2):147-53. Links
Reduced lipofuscin accumulation in senescent rat brain by long-term
acetyl-L-carnitine treatment.Amenta F, Ferrante F, Lucreziotti R,
Ricci A, Ramacci MT.
Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome,
Italy.

By using fluorescence microscopy and microfluorimetric techniques, the
effects of ageing and of 11 months acetyl-L-carnitine (ALCAR)
treatment on lipofuscin deposition within the cytoplasm of pyramidal
neurons of rat prefrontal cortex and hippocampus (CA3 field) were
assessed. No lipofuscin autofluorescence was observed in the nerve
cell bodies of neurons under study in young rats (3 months of age),
but lipopigment had accumulated in the same nerve cells of senescent
rats (22 months of age). ALCAR administration significantly reduced
the accumulation of lipofuscin within pyramidal neurons of the brain
areas examined.

PMID: 2589915 [PubMed - indexed for MEDLINE]

So if I understand this correctly not only does ALC reduce the
production of lipofuscin, but it also clears out deposits that have
already been formed. I have recently begun taking it. I am taking 1
gram in the morning. Is that a reasonable dose?

yes, and take R-lipoic acid as well to keep down mitochondrial ROS
production which would undesirably increase on ALCAR alone.

Good point jw, ALA should be added to the mix. In phototrop, a compound used
to treat AMD, and with some promising clinical results for early AMD, they
did witness regression of drusen. However in phototrop they did not include
ALA, a mistake in my view.

Lipofuscin is an important component of aging that is overlooked. In the
study originally cited the effective dosage was a whooping 100mg\kg\day!
50mg had little effect.

The work was done mice or rats wasn>t it. If so one has to allow
for their higher metabolic rate of the test subjects
and reduce the human dose accordingly.
Which likely puts the dose around a gram and half as an off hand
guess. Doable but expensive with r alpha lipoic acid.

the 50 and 100 mg/kg/day dose was in rats was ALCAR , not lipoic acid.

Beyond a century has a 50/50 alpha lipoic acid. Is that okay or is
there a source containing just the r form?

There are several sources of the R form, including Gronova and
Doctor>s Best. Also not you need extra boitin if you supplement with
lipoic acid.Some supplements include it, others do not.

Is there any benefit in taking a mixture of both forms? Or is it only
a good idea to take the R form?
[/quote]
re- R form vs. racemic mixture, read this: http://www.r-lipoic.com/
(I>m in no way connected w/ aor)

Ted · Guest

On Oct 9, 7:59 pm, jw <jwesl...@gmail.com> wrote:
[quote]On Oct 9, 1:58 pm, Ted <chuckfras...@gmail.com> wrote:

On Oct 8, 4:38 pm, r...@my-deja.com wrote:

On Oct 7, 7:29 pm, Ted <chuckfras...@gmail.com> wrote:

On Oct 6, 8:34 pm, jw <jwesl...@gmail.com> wrote:

On Oct 6, 5:37 am, "trigonometry1...@gmail.com |"

trigonometry1...@gmail.com> wrote:
On Oct 3, 8:24 pm, "John Hasenkam" <jo...@goawayplease.com> wrote:

"jw" <jwesl...@gmail.com> wrote in message

news:c8b7ab5e-8695-4431-8c92-6e3525537aef@l42g2000hsc.googlegroups.com...
On Oct 2, 5:47 pm, Ted <chuckfras...@gmail.com> wrote:

On Oct 2, 4:55 pm, timoth...@my-deja.com wrote:

Arch Gerontol Geriatr. 1989 Sep-Oct;9(2):147-53. Links
Reduced lipofuscin accumulation in senescent rat brain by long-term
acetyl-L-carnitine treatment.Amenta F, Ferrante F, Lucreziotti R,
Ricci A, Ramacci MT.
Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome,
Italy.

By using fluorescence microscopy and microfluorimetric techniques, the
effects of ageing and of 11 months acetyl-L-carnitine (ALCAR)
treatment on lipofuscin deposition within the cytoplasm of pyramidal
neurons of rat prefrontal cortex and hippocampus (CA3 field) were
assessed. No lipofuscin autofluorescence was observed in the nerve
cell bodies of neurons under study in young rats (3 months of age),
but lipopigment had accumulated in the same nerve cells of senescent
rats (22 months of age). ALCAR administration significantly reduced
the accumulation of lipofuscin within pyramidal neurons of the brain
areas examined.

PMID: 2589915 [PubMed - indexed for MEDLINE]

So if I understand this correctly not only does ALC reduce the
production of lipofuscin, but it also clears out deposits that have
already been formed. I have recently begun taking it. I am taking 1
gram in the morning. Is that a reasonable dose?

yes, and take R-lipoic acid as well to keep down mitochondrial ROS
production which would undesirably increase on ALCAR alone.

Good point jw, ALA should be added to the mix. In phototrop, a compound used
to treat AMD, and with some promising clinical results for early AMD, they
did witness regression of drusen. However in phototrop they did not include
ALA, a mistake in my view.

Lipofuscin is an important component of aging that is overlooked. In the
study originally cited the effective dosage was a whooping 100mg\kg\day!
50mg had little effect.

The work was done mice or rats wasn>t it. If so one has to allow
for their higher metabolic rate of the test subjects
and reduce the human dose accordingly.
Which likely puts the dose around a gram and half as an off hand
guess. Doable but expensive with r alpha lipoic acid.

the 50 and 100 mg/kg/day dose was in rats was ALCAR , not lipoic acid.

Beyond a century has a 50/50 alpha lipoic acid. Is that okay or is
there a source containing just the r form?

There are several sources of the R form, including Gronova and
Doctor>s Best. Also not you need extra boitin if you supplement with
lipoic acid.Some supplements include it, others do not.

Is there any benefit in taking a mixture of both forms? Or is it only
a good idea to take the R form?

re- R form vs. racemic mixture, read this:http://www.r-lipoic.com/
(I>m in no way connected w/ aor)
[/quote]
Wow that>s not good. I just ordered the racemate from beyond a century
because they did not offer the R by itself. I will be returning it.
Thanks for this!


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