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 Posted: Sat Oct 04, 2008 12:14 am Post subject: Glutathione reductase: stimulation in normal subjects by rib |
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Science. 1969 Aug 8;165(893):613-5. Links
Glutathione reductase: stimulation in normal subjects by riboflavin
supplementation.Beutler E.
Glutathione reductase of hemolyzates from clinically normal subjects
is activated by the addition of flavin-adenine dinucleotide. One-half
maximum stimulation could be achieved by approximately 0.02 micromolar
flavin-adenine dinucleotide; prior addition of adenosine triphosphate,
adenosine diphosphate, or adenosine mnonophosphate prevented
activation. Stimulation of glutathione reductase activity of red cells
of normal subjects occurred when they were given 5 milligrams of
riboflavin daily for 8 days. The degree of stimulation in vitro by
flavin-adenine dinucleotide and in vivo by riboflavin was inversely
proportional to dietary intake of riboflavin. The variety of clinical
disorders which have been associated with glutathione reductase
deficiency may have, as a common denominator, abnormalities in flavin-
adenine dinucleotide formation.
PMID: 5794396 [PubMed - indexed for MEDLINE] |
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