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ironjustice@aol.com
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 Posted: Wed Nov 19, 2008 3:34 pm Post subject: Garlic Derived Diabetes Treatment |
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Injection-free treatment for diabetes patients?
19 November 2008
A compound found in garlic is the basis of a potential orally-
available drug candidate for types 1 and 2 diabetes.
"Diabetes incidence is increasing worldwide, and there is a continuing
need to develop effective treatments"Diabetes incidence is increasing
worldwide, and there is a continuing need to develop effective
treatments. Exisiting treatments involve either injection with insulin
(primarily for sufferers of type 1 diabetes), or treatment with drugs
(for type 2 diabetes). However, says Hiromu Sakurai, of the Suzuka
University of Medical Science, Japan, neither method is ideal, as they
involve frequent injections, and the drugs have undesirable side-
effects.
In earlier work, Sakurai>s group had shown that a complex of vanadium
and allixin, a compound found in garlic, lowered blood glucose levels
in mouse models of both types 1 and 2 diabetes and that the effect was
maintained for type 2 model mice given the complex orally. In its
latest study the team found that the orally administered complex also
lowered glucose levels in type 1 model mice, offering hope for an
injection-free treatment for people with type 1 diabetes.
The vanadyl complex of garlic-compound allixin lowers blood glucose in
diabetes models
The new study looked primarily at how the allixin complex works. By
examining the effects of the complex on genes affected by diabetes,
the researchers found that it activates not only the insulin
signalling cascade, which regulates glucose metabolism, but also an
enzyme that helps cells to absorb glucose.
John McNeill is a professor emeritus in the division of pharmacology
and toxicology at the University of British Columbia, Vancouver,
Canada. He says that although other vanadium compounds have shown
promise for the treatment of diabetes, this investigation is extensive
and 'adds significant information to our understanding of how vanadium
compounds can affect both carbohydrate and lipid metabolism.'
"Allixin and similar complexes could be good candidates for treating
both type 1 and type 2 diabetes"
The researchers say that the allixin and similar complexes could be
good candidates for treating both type 1 and type 2 diabetes. Future
work, says Sakurai, will be aimed towards clinical trials of their
complexes in human diabetes patients.
David Barden
-------------------
Garlic chemical tablet treats diabetes I and II
19 November 2008
A drug based on a chemical found in garlic can treat diabetes types I
and II when taken as a tablet, a study in the new Royal Society of
Chemistry journal Metallomics says.
When Hiromu Sakurai and colleagues from the Suzuka University of
Medical Science, Japan, gave the drug orally to type I diabetic mice,
they found it reduced blood glucose levels.
The drug is based on vanadium and allaxin, a compound found in garlic,
and its action described in an Advance Article from Metallomics
available free online from today. The first issue of the new journal
will be published in 2009.
In previous work they had discovered the vanadium-allaxin compound
treated both diabetes types when injected, but this new study shows
the drug has promise as an oral treatment for the disease.
Type I diabetes (insulin dependent) is currently treated with daily
injections of insulin, while type II (non-insulin dependent) is
treated with drugs bearing undesirable side-effects - the authors note
neither treatment is ideal.
The researchers aim to test the drug in humans in future work.
ReferencesMakoto Hiromura, Metallomics, 2009, DOI: 10.1039/b815384c
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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jay
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| Posted: Wed Nov 19, 2008 6:58 pm Post subject: Re: Garlic Derived Diabetes Treatment |
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[quote]A compound found in garlic is the basis of a potential orally-
available drug candidate for types 1 and 2 diabetes.
[/quote]
A variety of anti-oxidants and anti-inflammatories are helpful in a
wide range of diseases. Avoiding exposure to persistent pollutant may
be helpful also. See
www.newscientist.com/article/mg19926731.900-could-the-diabetes-epidemic-be-down-to-pollution.html?full=true |
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rpautrey2
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| Posted: Thu Nov 20, 2008 12:28 am Post subject: Re: Garlic Derived Diabetes Treatment |
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Ironman,
Good Post! Every now-and-then you post a winner.
My only objection to the actual research is they
settled for garlic derivatives instead of settling on
the real deal, whole raw garlic. Why go second rate?
Paul
On Nov 19, 9:34 am, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
[quote]Injection-free treatment for diabetes patients?
19 November 2008
A compound found in garlic is the basis of a potential orally-
available drug candidate for types 1 and 2 diabetes.
"Diabetes incidence is increasing worldwide, and there is a continuing
need to develop effective treatments"Diabetes incidence is increasing
worldwide, and there is a continuing need to develop effective
treatments. Exisiting treatments involve either injection with insulin
(primarily for sufferers of type 1 diabetes), or treatment with drugs
(for type 2 diabetes). However, says Hiromu Sakurai, of the Suzuka
University of Medical Science, Japan, neither method is ideal, as they
involve frequent injections, and the drugs have undesirable side-
effects.
In earlier work, Sakurai>s group had shown that a complex of vanadium
and allixin, a compound found in garlic, lowered blood glucose levels
in mouse models of both types 1 and 2 diabetes and that the effect was
maintained for type 2 model mice given the complex orally. In its
latest study the team found that the orally administered complex also
lowered glucose levels in type 1 model mice, offering hope for an
injection-free treatment for people with type 1 diabetes.
The vanadyl complex of garlic-compound allixin lowers blood glucose in
diabetes models
The new study looked primarily at how the allixin complex works. By
examining the effects of the complex on genes affected by diabetes,
the researchers found that it activates not only the insulin
signalling cascade, which regulates glucose metabolism, but also an
enzyme that helps cells to absorb glucose.
John McNeill is a professor emeritus in the division of pharmacology
and toxicology at the University of British Columbia, Vancouver,
Canada. He says that although other vanadium compounds have shown
promise for the treatment of diabetes, this investigation is extensive
and 'adds significant information to our understanding of how vanadium
compounds can affect both carbohydrate and lipid metabolism.'
"Allixin and similar complexes could be good candidates for treating
both type 1 and type 2 diabetes"
The researchers say that the allixin and similar complexes could be
good candidates for treating both type 1 and type 2 diabetes. Future
work, says Sakurai, will be aimed towards clinical trials of their
complexes in human diabetes patients.
David Barden
-------------------
Garlic chemical tablet treats diabetes I and II
19 November 2008
A drug based on a chemical found in garlic can treat diabetes types I
and II when taken as a tablet, a study in the new Royal Society of
Chemistry journal Metallomics says.
When Hiromu Sakurai and colleagues from the Suzuka University of
Medical Science, Japan, gave the drug orally to type I diabetic mice,
they found it reduced blood glucose levels.
The drug is based on vanadium and allaxin, a compound found in garlic,
and its action described in an Advance Article from Metallomics
available free online from today. The first issue of the new journal
will be published in 2009.
In previous work they had discovered the vanadium-allaxin compound
treated both diabetes types when injected, but this new study shows
the drug has promise as an oral treatment for the disease.
Type I diabetes (insulin dependent) is currently treated with daily
injections of insulin, while type II (non-insulin dependent) is
treated with drugs bearing undesirable side-effects - the authors note
neither treatment is ideal.
The researchers aim to test the drug in humans in future work.
ReferencesMakoto Hiromura, Metallomics, 2009, DOI: 10.1039/b815384c
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk[/quote] |
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ironjustice
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| Posted: Thu Nov 20, 2008 12:38 am Post subject: Re: Garlic Derived Diabetes Treatment |
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On Nov 19, 4:28 pm, rpautrey2 <rpautr...@gmail.com> wrote:
Ironman, Good Post! <<
As if you>d know ..
You posting to my threads .. denigrates my threads ..
Understand .. ?
Good ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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rpautrey2
Guest
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| Posted: Thu Nov 20, 2008 12:47 am Post subject: Re: Garlic Derived Diabetes Treatment |
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Ironman: Nine times out of ten your posts denigrate yourself.
On Nov 19, 6:38 pm, ironjustice <teamtan...@hotmail.com> wrote:
[quote]On Nov 19, 4:28 pm, rpautrey2 <rpautr...@gmail.com> wrote:
Ironman, Good Post!
As if you>d know ..
You posting to my threads .. denigrates my threads ..
Understand .. ?
Good ..
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk[/quote] |
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ironjustice
Guest
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| Posted: Thu Nov 20, 2008 2:48 am Post subject: Re: Garlic Derived Diabetes Treatment |
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On Nov 19, 4:47 pm, rpautrey2 <rpautr...@gmail.com> wrote:
[quote]Ironman: Nine times out of ten your posts denigrate yourself.
[/quote]
Like I said .. pautry .. YOU would .. know .. ?
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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ironjustice
Guest
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| Posted: Thu Nov 20, 2008 3:05 am Post subject: Re: Garlic Derived Diabetes Treatment |
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On Nov 19, 7:34 am, "ironjust...@aol.com" <ironjust...@aol.com> wrote:
A compound found in garlic is the basis of a potential orally-
available drug candidate for types 1 and 2 diabetes. <<
"Garlic oil may suppress Fe-NTA-induced nephrotoxicity"
Food Chem Toxicol 1998 Jun;36(6):485-95
Attenuation of iron-nitrilotriacetate (Fe-NTA)-mediated renal
oxidative stress,
toxicity and hyperproliferative response by the prophylactic treatment
of rats
with garlic oil.
Iqbal M, Athar M
Department of Medical Elementology and Toxicology, Faculty of
Science,
Jamia Hamdard (Hamdard University), New Delhi, India.
Iron nitrilotriacetate (Fe-NTA) is a potent nephrotoxic agent. In
this
communication we show that Fe-NTA-mediated nephrotoxicity is
diminished by 1 wk of oral daily pretreatment of male albino
Wistar
rats with garlic oil given by gavage at 50 or 100 mg/kg body weight/
ml
corn oil. Intraperitoneal Fe-NTA treatment at a dose level of 9 mg
Fe/kg body weight/10 ml enhances renal microsomal lipid
peroxidation
and hydrogen peroxide generation which are accompanied by a
decrease
in the activities of renal antioxidant enzymes (e.g. catalase,
glutathione peroxidase, glutathione reductase and glutathione
S-transferase), and a depletion in the level of renal glutathione.
Parallel to these changes, a sharp increase in blood urea nitrogen
and
serum creatinine has been observed. In addition, Fe-NTA treatment
also
enhances renal ornithine decarboxylase (ODC) activity and
increases
[3H]thymidine incorporation into renal DNA. Prophylactic treatment
of
animals with garlic oil before the administration of Fe-NTA
resulted
in the diminution of Fe-NTA mediated injury. The enhancement of
renal
lipid peroxidation and hydrogen peroxide generation was decreased.
In
addition, there was recovery of glutathione depletion and
inhibition
of the activities of antioxidant enzymes. Similarly, in animals
given
the higher dose of garlic oil (100 mg/kg body weight) the enhanced
blood urea nitrogen and serum creatinine levels, which are
indicative
of renal injury, showed a reduction of about 30% and 40%,
respectively, in comparison with the group treated with Fe-NTA
alone.
Pretreatment with garlic oil also ameliorated the Fe-NTA-mediated
induction of ODC activity and enhancement of [3H]thymidine
incorporation into DNA in a dose-dependent manner. Our data
suggest
that garlic oil is a potent chemopreventive agent and may suppress
Fe-NTA-induced nephrotoxicity.
PMID: 9674956, UI: 98337713
--------------------------
http://www.clinicaltrials.gov/show/NCT00230087
Iron Depletion Therapy for Type 2 DM and NAFLD
This study is currently recruiting patients.
Verified by National Institute of Diabetes and Digestive and Kidney
Diseases (NIDDK) March 2006
---------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/634q5a
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
[quote]
"Diabetes incidence is increasing worldwide, and there is a continuing
need to develop effective treatments"Diabetes incidence is increasing
worldwide, and there is a continuing need to develop effective
treatments. Exisiting treatments involve either injection with insulin
(primarily for sufferers of type 1 diabetes), or treatment with drugs
(for type 2 diabetes). However, says Hiromu Sakurai, of the Suzuka
University of Medical Science, Japan, neither method is ideal, as they
involve frequent injections, and the drugs have undesirable side-
effects.
In earlier work, Sakurai>s group had shown that a complex of vanadium
and allixin, a compound found in garlic, lowered blood glucose levels
in mouse models of both types 1 and 2 diabetes and that the effect was
maintained for type 2 model mice given the complex orally. In its
latest study the team found that the orally administered complex also
lowered glucose levels in type 1 model mice, offering hope for an
injection-free treatment for people with type 1 diabetes.
The vanadyl complex of garlic-compound allixin lowers blood glucose in
diabetes models
The new study looked primarily at how the allixin complex works. By
examining the effects of the complex on genes affected by diabetes,
the researchers found that it activates not only the insulin
signalling cascade, which regulates glucose metabolism, but also an
enzyme that helps cells to absorb glucose.
John McNeill is a professor emeritus in the division of pharmacology
and toxicology at the University of British Columbia, Vancouver,
Canada. He says that although other vanadium compounds have shown
promise for the treatment of diabetes, this investigation is extensive
and 'adds significant information to our understanding of how vanadium
compounds can affect both carbohydrate and lipid metabolism.'
"Allixin and similar complexes could be good candidates for treating
both type 1 and type 2 diabetes"
The researchers say that the allixin and similar complexes could be
good candidates for treating both type 1 and type 2 diabetes. Future
work, says Sakurai, will be aimed towards clinical trials of their
complexes in human diabetes patients.
David Barden
-------------------
Garlic chemical tablet treats diabetes I and II
19 November 2008
A drug based on a chemical found in garlic can treat diabetes types I
and II when taken as a tablet, a study in the new Royal Society of
Chemistry journal Metallomics says.
When Hiromu Sakurai and colleagues from the Suzuka University of
Medical Science, Japan, gave the drug orally to type I diabetic mice,
they found it reduced blood glucose levels.
The drug is based on vanadium and allaxin, a compound found in garlic,
and its action described in an Advance Article from Metallomics
available free online from today. The first issue of the new journal
will be published in 2009.
In previous work they had discovered the vanadium-allaxin compound
treated both diabetes types when injected, but this new study shows
the drug has promise as an oral treatment for the disease.
Type I diabetes (insulin dependent) is currently treated with daily
injections of insulin, while type II (non-insulin dependent) is
treated with drugs bearing undesirable side-effects - the authors note
neither treatment is ideal.
The researchers aim to test the drug in humans in future work.
ReferencesMakoto Hiromura, Metallomics, 2009, DOI: 10.1039/b815384c
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/634q5a
Man Is A Herbivore!http://tinyurl.com/4rq595
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk[/quote] |
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Guest
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| Posted: Fri Nov 21, 2008 8:03 am Post subject: Re: Garlic Derived Diabetes Treatment |
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"As if you>d know ..
You posting to my threads .. denigrates my threads ..
Understand .. ?"
No, but it is clearly understood by *-* ALL *-* who read your childish
No, but it is clearly understood by *-* ALL *-* who read your childish
responses and rants which denigrates yourself. You are your own worst
nightmare and critical error.
You do not own threads nor the information you post by way of your own
creation. It comes from real researchers who do not live in a fantasy
world in a cut and paste universe who are hobbled by obsessive and
compulsive personality disorders. Your peace of mind would be much
greater if you refused the compulsion to ever touch a search enjine ever
again.
I>m sorry life has left you so sad and bitter in your old age. |
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ironjustice@aol.com
Guest
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| Posted: Fri Nov 21, 2008 3:13 pm Post subject: Re: Garlic Derived Diabetes Treatment |
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On Nov 20, 6:03 pm, anonym...@nowhere.you.know wrote: snip <<
I>m not sure you really understand how this works there.. whacko ..
I gave up reading your crud long ago there .. whacko ..
YOU hit the .. road ..
Understand there creeeeeeepoo .. ?
Do ya .. ?
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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Guest
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| Posted: Sun Nov 23, 2008 12:34 am Post subject: Re: Garlic Derived Diabetes Treatment |
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| I>m sorry life has left you so sad and bitter in your old age. |
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ironjustice@aol.com
Guest
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| Posted: Mon Nov 24, 2008 1:16 am Post subject: Re: Garlic Derived Diabetes Treatment |
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On Nov 22, 10:34 am, anonym...@nowhere.you.know wrote:snip <<
I>m not sure you really understand how this works there.. whacko ..
YOU hit the .. road ..
Understand there creeeeeeepoo .. ?
Do ya .. ?
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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percy
Guest
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| Posted: Tue Nov 25, 2008 4:48 am Post subject: Re: Garlic Derived Diabetes Treatment |
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ironjustice@aol.com wrote:
[quote]On Nov 22, 10:34 am, anonym...@nowhere.you.know wrote:snip
I>m not sure you really understand how this works there.. whacko ..
YOU hit the .. road ..
Understand there creeeeeeepoo .. ?
Do ya .. ?
[/quote]
Or what, rustbucket? Gonna beat him with a malformed ellipsis?
Your ISP, telus, doesn>t like people who make threats. It says so right
in their Acceptable Use Policy.
(ko0klinks snipped) |
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ironjustice
Guest
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| Posted: Tue Nov 25, 2008 4:33 pm Post subject: Re: Garlic Derived Diabetes Treatment |
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On Nov 24, 2:48 pm, percy <vbeausol...@nowhere.bum> wrote:
Your ISP, telus, doesn>t like people who make threats. It says so
right
in their Acceptable Use Policy.<<
Neither do I .. percy ..
I notice you didn>t say a whole lot about diabetes OR .. garlic .. did
ya .. percy ..
**I** don>t like it when people post off topic on my threads ..
Do you understand .. Per .. cey .. boi ..
Don>t do it again .. per .. cey .. boi ..
Understand .. ?
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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Guest
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| Posted: Tue Nov 25, 2008 10:40 pm Post subject: Re: Garlic Derived Diabetes Treatment |
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Your ISP, telus, doesn>t like people who make threats. It says so
right
in their Acceptable Use Policy.<<
"Neither do I .. percy ..
I notice you didn>t say a whole lot about diabetes OR .. garlic .. did
ya .. percy ..
**I** don>t like it when people post off topic on my threads ..
Do you understand .. Per .. cey .. boi ..
Don>t do it again .. per .. cey .. boi ..
Understand .. ?"
No, don>t understand anything but that you are a nasty person who can
not respond on the merits of the flaws people see in your ideas and
mostly misunderstood abstracts.
I>m sorry old age finds you a bitter and sad old man. |
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ironjustice
Guest
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| Posted: Thu Nov 27, 2008 12:26 am Post subject: Re: Garlic Derived Diabetes Treatment |
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On Nov 25, 8:40 am, anonym...@nowhere.you.know wrote: snip <<
You were told to stay off my threads .. dioxin boy ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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