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 Posted: Tue Oct 07, 2008 2:42 pm Post subject: Cocaine-like neurochemical effects of antihistaminic medicat |
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Tanda G, Kopajtic TA, Katz JL.
Psychobiology Section, Medications Discovery Research Branch,
Department of Health and Human Services, National Institute on Drug
Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA.
gtanda@intra.nida.nih.gov
The pattern of activation of dopamine (DA) neurotransmission in the
nucleus accumbens (NAc) of rats produced by H(1) histamine antagonists
which have behavioral effects like those of psychostimulant drugs was
examined. Diphenhydramine and (+)-chlorpheniramine were compared with
triprolidine, a potent and selective H(1) antagonist and (-)-
chlorpheniramine which is less active than its enantiomer at H(1)
receptors. Affinities of the drugs to DA, serotonin, and
norepinephrine transporters at H(1) receptors and potencies for DA
uptake inhibition in striatal synaptosomes were determined to assess
mechanisms by which the compounds increased DA levels. Intravenous
diphenhydramine (1.0-3.0 mg/kg) (+)- and (-)-chlorpheniramine (1.0-5.6
mg/kg) but not triprolidine (1.0-3.0 mg/kg) elicited a cocaine-like
pattern of stimulation of DA transmission with larger effects in the
NAc shell than core. The absence of stereospecific effects with
chlorpheniramine enantiomers along with the lack of an effect with
triprolidine suggest that the effects on DA transmission were not
related to H(1) receptor antagonism. Although in vivo potencies were
not directly related to DA transporter affinities, it is hypothesized
that actions at that site modulated by other actions, possibly those
at the serotonin transporter, are primarily responsible for the
neurochemical actions of the drugs on DA neurotransmission and might
underlie the occasional misuse of these medications.
PMID: 18363822 [PubMed - indexed for MEDLINE]
Question: There is one thing that I notice when I take antihistamines
(Xusal) and what I even notice much more when I take a leukotriene
inhibitor (Singulair): I>m able to socialise and talk in a highly
improved way (in my eyes, the dopamine is responsible for this). It
seems to have a detrimental effect on learning however since I>m kind
of stimulated.
It takes 3 hours for the effect to begin after I took 5 mg Singulair
and it lasts about half a day but under certain unknown conditions
even can last up to several days. The effect with Xusal is weaker but
still noticable.
Does anyone know why Singulair has that effect or what is even more
important why it can>t be doublicated on the following day?
I need at least 1 week between the intakes in order to get that
effect. Continued use even seems to depress mood.
I have a HHV-7 reactivation and I>m a lot more sensitive to every food/
supplement/medication than others. |
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