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 Posted: Fri Oct 03, 2008 9:10 pm Post subject: Age-associated alterations of lipofuscin, membrane-bound ATP |
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Int J Dev Neurosci. 2008 Apr;26(2):211-5. Epub 2007 Dec 23. Links
Age-associated alterations of lipofuscin, membrane-bound ATPases and
intracellular calcium in cortex, striatum and hippocampus of rat
brain: protective role of glutathione monoester.Murali G,
Panneerselvam KS, Panneerselvam C.
Department of Medical Biochemistry, Dr. ALM Postgraduate Institute of
Basic Medical Sciences, University of Madras, Taramani Campus, Chennai
600113, India.
Brain aging has become an area of intense research and a subject of
much speculation fueled largely from the widely recognized fact that
age is the biggest risk factor in most neurodegenerative diseases and
age-related increase of reactive oxygen species is particularly
detrimental to postmitotic tissues. In the present study, we have
evaluated the possible role of glutathione monoester (GME), when
administered intraperitoneally (12mg/kg body weight) for 20 days on
age-associated changes in the levels of lipofuscin, Na+K+, Mg2+, Ca2+
ATPase activities and intracellular calcium levels in discrete brain
regions of young and aged male albino Wistar rats. An age-associated
increase in lipofuscin, intracellular calcium in cortex, striatum and
hippocampus was observed and contradictorily, a decrease in the
activities of membrane-bound enzyme activities was also observed.
Supplementation of GME brought these changes to near normalcy. Thus,
GME improves neuronal antioxidant status, thereby effectively
attenuating any putative increase in oxidative stress with age.
PMID: 18242929 [PubMed - indexed for MEDLINE] |
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